ID   SLD2_NEUCR              Reviewed;         610 AA.
AC   Q7S438;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=DNA replication regulator sld2;
DE   AltName: Full=DNA replication complex protein 4;
GN   Name=drc-4; Synonyms=sld2; ORFNames=NCU02241;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002242; EAA30264.2; -; Genomic_DNA.
DR   RefSeq; XP_959500.2; XM_954407.2.
DR   AlphaFoldDB; Q7S438; -.
DR   SMR; Q7S438; -.
DR   STRING; 5141.EFNCRP00000003194; -.
DR   PRIDE; Q7S438; -.
DR   EnsemblFungi; EAA30264; EAA30264; NCU02241.
DR   GeneID; 3875649; -.
DR   KEGG; ncr:NCU02241; -.
DR   VEuPathDB; FungiDB:NCU02241; -.
DR   HOGENOM; CLU_033089_0_0_1; -.
DR   InParanoid; Q7S438; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..610
FT                   /note="DNA replication regulator sld2"
FT                   /id="PRO_0000278437"
FT   REGION          28..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..389
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..441
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..460
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..503
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..576
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  67751 MW;  C1A5A7AFCFB8EB8F CRC64;
     MMDEQRKAEY ESQSLQLRAE LKQFEAEWAQ KNDGKKPSRE AIKQNPDIAQ KYKQYNKLRD
     ILSGKIPPPT KSNNQDPSQR KRKQPETSLP SASTPSKRNR SAATPKSQHY SAVHEAITPD
     VARKLFSPAV PSSIGPTPQK DGRVLGLFDL ISHTPSKSTD ETKPRASGFT ATPSNRRHAL
     DLENDKDDDD HDEKDGKEFI TPSIPRHRNL DRTPSSGRNR NLLDSFLGVR ATKTSTPLNK
     NTGNSPSKNN LTKTPSGERS VSKLQFATPA FLRRTSAPLP PVDENGEWLD IEPLKLPRKP
     FSIAKGKGLS SVVASLRKME EEKLDEELDM LREMEAMEQG GMGPPPPKQT VASTSEDTEK
     KKQVTDPAGA EVVPEEENSF EEDEAALIEV EASFLESPSS KRKKERRPVL LSGFDDENFY
     DSQDEEDLSK EGLDRNGQPL RVFKKKGQKR TTRKVNMRPT RTKRPSAPIA EEEDDGEEEH
     NDVIPETQFD ATKNLDGDDH HTLDSLSSGG SGSEFDDGSE GEDEEAETST TKAAKAAAKK
     KAPSAKEKTK KDATTETKKK KGTKEGGDEE PAKKPRMVKA TANANFKRLK LKNNGAKGGP
     AHNSRFRRRR