ID   SLD2_YARLI              Reviewed;         390 AA.
AC   Q6C7D7;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=DNA replication regulator SLD2;
GN   Name=SLD2; OrderedLocusNames=YALI0E01650g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in the initiation of DNA replication. Required at
CC       S-phase checkpoint (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD2 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79004.1; -; Genomic_DNA.
DR   RefSeq; XP_503425.1; XM_503425.1.
DR   AlphaFoldDB; Q6C7D7; -.
DR   SMR; Q6C7D7; -.
DR   STRING; 4952.CAG79004; -.
DR   EnsemblFungi; CAG79004; CAG79004; YALI0_E01650g.
DR   GeneID; 2912047; -.
DR   KEGG; yli:YALI0E01650g; -.
DR   VEuPathDB; FungiDB:YALI0_E01650g; -.
DR   HOGENOM; CLU_708235_0_0_1; -.
DR   InParanoid; Q6C7D7; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR   InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR   InterPro; IPR040203; Sld2.
DR   PANTHER; PTHR28124; PTHR28124; 1.
DR   Pfam; PF11719; Drc1-Sld2; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..390
FT                   /note="DNA replication regulator SLD2"
FT                   /id="PRO_0000278439"
FT   REGION          46..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  43731 MW;  80DDE9001B6F0F4E CRC64;
     MDIQTLRSEI KAWERAYADK HGRKPTPKEV KADPIAKKYH LYNKFKKAES AGTGPSTPKR
     ASKLHSSLNY KPVSFSVKTP EKQISKNRRR SVSKQQHADI VTPSHRSLTF SKAPALSRTP
     QKQLQDTPKA ATPKPSPSVP LGPTPSIHGR VVSLLEGLDG TPVKEFATPG NVSTPVKVVS
     ITSETPTNKP ALDVNDEFTT PAYLNRISVD VSPFEKRLSF AERIRQSVVE SPIKQMSPEK
     ELSPANQTEE YDDDEDAWRE LEGLPPKPKE PKIVDVTFDG EEPDELDEIM GTVEVHNPYD
     EPVQDDLDWV HETALEGETA LSAPIYKEGG IKKRKHQTQK RTTKKAIVRV ESEQHKKAKV
     DNDNFSTTNR LNTGFKVNMG QKQWASRFKK