SLD5_ASHGO
ID SLD5_ASHGO Reviewed; 266 AA.
AC Q753I0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=DNA replication complex GINS protein SLD5;
GN Name=SLD5; OrderedLocusNames=AFR332W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 149.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. Has a role in chromosome segregation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53703.2; -; Genomic_DNA.
DR RefSeq; NP_985879.2; NM_211234.2.
DR AlphaFoldDB; Q753I0; -.
DR SMR; Q753I0; -.
DR STRING; 33169.AAS53703; -.
DR EnsemblFungi; AAS53703; AAS53703; AGOS_AFR332W.
DR GeneID; 4622144; -.
DR KEGG; ago:AGOS_AFR332W; -.
DR eggNOG; KOG3176; Eukaryota.
DR HOGENOM; CLU_071893_2_0_1; -.
DR InParanoid; Q753I0; -.
DR OMA; ILETAWI; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206; PTHR21206; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 3: Inferred from homology;
KW Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..266
FT /note="DNA replication complex GINS protein SLD5"
FT /id="PRO_0000255428"
SQ SEQUENCE 266 AA; 29642 MW; 5E62F9774491905B CRC64;
MDINIDDILA DLDRDTTAVG STPAPAGDDT TRLDDSAATV AADYSTLVTH WCNERVAPEL
LPYPHTLMAR VLARLAAQIE HLETLSTGVL EQTLDRSAKL PLLCMEAELE RLKFVVRSLL
RCRLGKIDRF GLYLRQLDAR SPGALQTLLS AQERVYYERH SAILLKLFNN AILRHMPAEM
QAVDDTEGSV SMIDEPEWAR FVFLYVREPA PDAPDPLLAV DDHGQPCYSV NIPELGEVVD
LAVGGIYIMR YNVIKDLLMD GKVVLI
