ID   SLD5_BOVIN              Reviewed;         223 AA.
AC   A2VE40;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA replication complex GINS protein SLD5;
DE   AltName: Full=GINS complex subunit 4;
GN   Name=GINS4; Synonyms=SLD5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication, and progression of DNA replication forks. GINS4 is
CC       important for GINS complex assembly. GINS complex seems to bind
CC       preferentially to single-stranded DNA. {ECO:0000250|UniProtKB:Q9BRT9}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1.
CC       GINS complex interacts with DNA primase in vitro (By similarity).
CC       Component of the CMG helicase complex, composed of the MCM2-7 complex,
CC       the GINS complex and CDC45 (By similarity).
CC       {ECO:0000250|UniProtKB:Q7ZT48, ECO:0000250|UniProtKB:Q9BRT9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99LZ3}.
CC       Chromosome {ECO:0000250|UniProtKB:Q7ZT48}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q99LZ3}.
CC   -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR   EMBL; BC133560; AAI33561.1; -; mRNA.
DR   RefSeq; NP_001075929.1; NM_001082460.2.
DR   AlphaFoldDB; A2VE40; -.
DR   SMR; A2VE40; -.
DR   STRING; 9913.ENSBTAP00000022773; -.
DR   PaxDb; A2VE40; -.
DR   PRIDE; A2VE40; -.
DR   Ensembl; ENSBTAT00000022773; ENSBTAP00000022773; ENSBTAG00000017133.
DR   GeneID; 616799; -.
DR   KEGG; bta:616799; -.
DR   CTD; 84296; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017133; -.
DR   VGNC; VGNC:29363; GINS4.
DR   eggNOG; KOG3176; Eukaryota.
DR   GeneTree; ENSGT00390000003246; -.
DR   HOGENOM; CLU_071893_3_0_1; -.
DR   InParanoid; A2VE40; -.
DR   OMA; ILETAWI; -.
DR   OrthoDB; 1434266at2759; -.
DR   TreeFam; TF105863; -.
DR   Reactome; R-BTA-176974; Unwinding of DNA.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000017133; Expressed in oocyte and 95 other tissues.
DR   GO; GO:0071162; C:CMG complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR   GO; GO:1903934; P:positive regulation of DNA primase activity; IEA:Ensembl.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; IEA:Ensembl.
DR   CDD; cd11711; GINS_A_Sld5; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR008591; GINS_Sld5.
DR   InterPro; IPR031633; SLD5_C.
DR   InterPro; IPR038749; Sld5_GINS_A.
DR   PANTHER; PTHR21206; PTHR21206; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   Pfam; PF16922; SLD5_C; 1.
DR   PIRSF; PIRSF007764; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chromosome; Cytoplasm; DNA replication; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..223
FT                   /note="DNA replication complex GINS protein SLD5"
FT                   /id="PRO_0000327619"
FT   REGION          166..223
FT                   /note="Important for GINS complex assembly"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRT9"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRT9"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRT9"
SQ   SEQUENCE   223 AA;  26080 MW;  7D6FA877EBA08496 CRC64;
     MAEEADLLGQ DSDGDSEEVI LTPAELIDRL EQAWMNEKFA PELLENKSEI VECVMEQLEH
     MEENLKRAKK GDLKVSIHQM EMERIRFVLS SYLRCRLMKI EKFFPHTLEK EKTRREEEPP
     ILSPEELVFA KEFLANTETY LKDTALKHMP PNLQKVDLLR TVPKPDLDAY VFLRVKERQE
     NILVEPENDE QRDYVIDLEE GSQHLMRYRT VAPLVASGAI QLI