SLD5_CANGA
ID SLD5_CANGA Reviewed; 309 AA.
AC Q6FT85;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=DNA replication complex GINS protein SLD5;
GN Name=SLD5; OrderedLocusNames=CAGL0G04587g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. Has a role in chromosome segregation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR EMBL; CR380953; CAG59486.1; -; Genomic_DNA.
DR RefSeq; XP_446559.1; XM_446559.1.
DR AlphaFoldDB; Q6FT85; -.
DR SMR; Q6FT85; -.
DR STRING; 5478.XP_446559.1; -.
DR PRIDE; Q6FT85; -.
DR EnsemblFungi; CAG59486; CAG59486; CAGL0G04587g.
DR GeneID; 2888425; -.
DR KEGG; cgr:CAGL0G04587g; -.
DR CGD; CAL0137781; CAGL0G04587g.
DR VEuPathDB; FungiDB:CAGL0G04587g; -.
DR eggNOG; KOG3176; Eukaryota.
DR HOGENOM; CLU_071893_2_0_1; -.
DR InParanoid; Q6FT85; -.
DR Proteomes; UP000002428; Chromosome G.
DR GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR GO; GO:0000811; C:GINS complex; IEA:EnsemblFungi.
DR GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206; PTHR21206; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 3: Inferred from homology;
KW Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..309
FT /note="DNA replication complex GINS protein SLD5"
FT /id="PRO_0000255429"
SQ SEQUENCE 309 AA; 35585 MW; 92DF3DCDA35462FD CRC64;
MDIDIDDILA ELDRDTTAVA SSSGQHGFLD ANSSMQHVTQ TTAFDSSLPH ANNLQKDYSP
VTPEQDYLQL LKHWRNERCA PELLPLPKLL VSRMLKRIQD QMEHIENISM GFLEHEILEK
DGEEAIGQNE YQNNALNNGK LPLLCMEAEL ERVKFVMRSY LRCRLNKIDK YSLYLRQLGD
QGINLISLDE LMSEQELKYH AKHSVILLKL LNNSILRHMP PELQAINDTE GSVSMIEEPN
WKKFVFIYVN GPANVADDPQ LQQSEDGKYY YNITIPEFDE IVELTTGSIY VMRYDIVKDL
LRDGKVELI