ID   SLD5_DEBHA              Reviewed;         245 AA.
AC   Q6BXX6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA replication complex GINS protein SLD5;
GN   Name=SLD5; OrderedLocusNames=DEHA2A14102g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. Has a role in chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84921.1; -; Genomic_DNA.
DR   RefSeq; XP_456943.1; XM_456943.1.
DR   AlphaFoldDB; Q6BXX6; -.
DR   SMR; Q6BXX6; -.
DR   STRING; 4959.XP_456943.1; -.
DR   EnsemblFungi; CAG84921; CAG84921; DEHA2A14102g.
DR   GeneID; 2899394; -.
DR   KEGG; dha:DEHA2A14102g; -.
DR   VEuPathDB; FungiDB:DEHA2A14102g; -.
DR   eggNOG; KOG3176; Eukaryota.
DR   HOGENOM; CLU_071893_2_0_1; -.
DR   InParanoid; Q6BXX6; -.
DR   OMA; ILETAWI; -.
DR   OrthoDB; 1434266at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   CDD; cd11711; GINS_A_Sld5; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR008591; GINS_Sld5.
DR   InterPro; IPR031633; SLD5_C.
DR   InterPro; IPR038749; Sld5_GINS_A.
DR   PANTHER; PTHR21206; PTHR21206; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   Pfam; PF16922; SLD5_C; 1.
DR   PIRSF; PIRSF007764; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..245
FT                   /note="DNA replication complex GINS protein SLD5"
FT                   /id="PRO_0000255431"
SQ   SEQUENCE   245 AA;  28467 MW;  75616B269F2A8695 CRC64;
     MNKDLDIDDI LQEFDDSNVH SKSSKYGIRN SENIYDQLVA AMLNERMSPD VLPYKHELMK
     EVLTQLSNQQ QYLLDSHEYG DSNVESGIVT GDFKLQLMII ETDIERLNYL VRLYLRTRLA
     KIDKFTIHYI NETSNDDPTN DRSLLSPEET EYMHKHFKIL TQLYNNSFLK KMPHFLTLLD
     DTSGGQSMIS VPDINQPVFI KVITKVPIII NLDEDEDLEL VENGIYVVKY SLIKKYIEIG
     DIVLI