ID   SLD5_DICDI              Reviewed;         211 AA.
AC   Q55EA2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA replication complex GINS protein SLD5;
DE   AltName: Full=GINS complex subunit 4;
GN   Name=gins4; ORFNames=DDB_G0269324;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       gins1, gins2, gins3 and gins4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72012.2; -; Genomic_DNA.
DR   RefSeq; XP_645879.2; XM_640787.2.
DR   AlphaFoldDB; Q55EA2; -.
DR   SMR; Q55EA2; -.
DR   STRING; 44689.DDB0266356; -.
DR   PaxDb; Q55EA2; -.
DR   EnsemblProtists; EAL72012; EAL72012; DDB_G0269324.
DR   GeneID; 8616819; -.
DR   KEGG; ddi:DDB_G0269324; -.
DR   dictyBase; DDB_G0269324; gins4.
DR   eggNOG; KOG3176; Eukaryota.
DR   HOGENOM; CLU_071893_3_0_1; -.
DR   InParanoid; Q55EA2; -.
DR   OMA; ILETAWI; -.
DR   PhylomeDB; Q55EA2; -.
DR   Reactome; R-DDI-176974; Unwinding of DNA.
DR   PRO; PR:Q55EA2; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0000811; C:GINS complex; ISS:dictyBase.
DR   GO; GO:0006260; P:DNA replication; ISS:dictyBase.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   CDD; cd11711; GINS_A_Sld5; 1.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR008591; GINS_Sld5.
DR   InterPro; IPR031633; SLD5_C.
DR   InterPro; IPR038749; Sld5_GINS_A.
DR   PANTHER; PTHR21206; PTHR21206; 1.
DR   Pfam; PF16922; SLD5_C; 1.
DR   PIRSF; PIRSF007764; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..211
FT                   /note="DNA replication complex GINS protein SLD5"
FT                   /id="PRO_0000327630"
SQ   SEQUENCE   211 AA;  24943 MW;  31892AC2E05C27DB CRC64;
     MMSGEYGDFN NTNNKELSLL DKLKKAWINE KYAPNLLNYE DVIIKEVMEK IEEKESLCAS
     AISNINLQFT ANIYEMEIER LKYIIKCYLV QRIKKIDKFY SSILLEIEND EYDSYKLLSE
     FEINYCQKYK ALMDGYFKNT LLNSIPKDFQ KMDSNSINRP FLNTFVFCKP REDLGDFLVD
     DETIDFKKTS IYFLKYLPIK SLVEGGKMDL I