ID   SLD5_KLULA              Reviewed;         292 AA.
AC   Q6CKF3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=DNA replication complex GINS protein SLD5;
GN   Name=SLD5; OrderedLocusNames=KLLA0F11121g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. Has a role in chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98294.1; -; Genomic_DNA.
DR   RefSeq; XP_455586.1; XM_455586.1.
DR   AlphaFoldDB; Q6CKF3; -.
DR   SMR; Q6CKF3; -.
DR   STRING; 28985.XP_455586.1; -.
DR   EnsemblFungi; CAG98294; CAG98294; KLLA0_F11121g.
DR   GeneID; 2895125; -.
DR   KEGG; kla:KLLA0_F11121g; -.
DR   eggNOG; KOG3176; Eukaryota.
DR   HOGENOM; CLU_071893_2_0_1; -.
DR   InParanoid; Q6CKF3; -.
DR   OMA; ILETAWI; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0071162; C:CMG complex; IEA:EnsemblFungi.
DR   GO; GO:0000811; C:GINS complex; IEA:EnsemblFungi.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR   CDD; cd11711; GINS_A_Sld5; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR008591; GINS_Sld5.
DR   InterPro; IPR031633; SLD5_C.
DR   InterPro; IPR038749; Sld5_GINS_A.
DR   PANTHER; PTHR21206; PTHR21206; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   Pfam; PF16922; SLD5_C; 1.
DR   PIRSF; PIRSF007764; Sld5; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..292
FT                   /note="DNA replication complex GINS protein SLD5"
FT                   /id="PRO_0000255433"
FT   REGION          16..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  33573 MW;  D18EA4E17DD66145 CRC64;
     MSIDIDDILA ELDRDTTAVE QNASSYPDQS DRTQGNDVSQ IRPADKAVDP VAPTQFNKID
     DYQKLITHWK NERMSPELLP YPHHLMTRTL IRIQERIELI ETLSMGYLED NQELTVDSKL
     PLLCMEAELE RLKFLVRSFI RCRLSKIDKY SIYLRQQSEL PNNAGLSRLD LLMSKEEVKY
     HMKHSDILLK LFNNAVLKHL PEELQAVNDT EGSISMIDEP DWNKTVFILV CGGVVDESGI
     DSKLTTDDDG KHCYSVIIED LNEEIYLLIG AVYVIRYSVI RDLMTEGRVV LI