SLD5_SCHPO
ID SLD5_SCHPO Reviewed; 214 AA.
AC Q9P7C8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=DNA replication complex GINS protein sld5;
GN Name=sld5; ORFNames=SPBP4H10.21c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND INTERACTION WITH PSF2.
RX PubMed=16199877; DOI=10.1128/mcb.25.20.9000-9015.2005;
RA Huang H.-K., Bailis J.M., Leverson J.D., Gomez E.B., Forsburg S.L.,
RA Hunter T.;
RT "Suppressors of Bir1p (Survivin) identify roles for the chromosomal
RT passenger protein Pic1p (INCENP) and the replication initiation factor
RT Psf2p in chromosome segregation.";
RL Mol. Cell. Biol. 25:9000-9015(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. Has a role in chromosome segregation and is required
CC for bir1 localization. {ECO:0000269|PubMed:16199877}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC sld5, psf1, psf2 and psf3. Interacts with sld5.
CC {ECO:0000269|PubMed:16199877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB83179.1; -; Genomic_DNA.
DR RefSeq; NP_596195.1; NM_001022114.2.
DR AlphaFoldDB; Q9P7C8; -.
DR SMR; Q9P7C8; -.
DR BioGRID; 277879; 9.
DR IntAct; Q9P7C8; 2.
DR MINT; Q9P7C8; -.
DR STRING; 4896.SPBP4H10.21c.1; -.
DR PaxDb; Q9P7C8; -.
DR EnsemblFungi; SPBP4H10.21c.1; SPBP4H10.21c.1:pep; SPBP4H10.21c.
DR GeneID; 2541368; -.
DR KEGG; spo:SPBP4H10.21c; -.
DR PomBase; SPBP4H10.21c; sld5.
DR VEuPathDB; FungiDB:SPBP4H10.21c; -.
DR eggNOG; KOG3176; Eukaryota.
DR HOGENOM; CLU_071893_1_1_1; -.
DR InParanoid; Q9P7C8; -.
DR OMA; ILETAWI; -.
DR PhylomeDB; Q9P7C8; -.
DR Reactome; R-SPO-176974; Unwinding of DNA.
DR PRO; PR:Q9P7C8; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000811; C:GINS complex; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IC:PomBase.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206; PTHR21206; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; SSF158573; 1.
PE 1: Evidence at protein level;
KW Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..214
FT /note="DNA replication complex GINS protein sld5"
FT /id="PRO_0000255434"
SQ SEQUENCE 214 AA; 24989 MW; 9B1C7E50A471891F CRC64;
MEWDADDLLI EPTTEVENDY EDLCTQWVNE RMAPDLLPFA EEIVSRVLDR IEAQRETLQL
AIGTSSATSY RSVLMQTELE RVKFVLRSYM RTRINKIDKY AQYIQSHPNL LLYLSSPERQ
YLLRHQQIVH RHYMDSFLRE VPAKMNKLDD KVGNLSMVAS PDMDTAVFCV VNESVEENFR
VSENEYITLD KGDVLILRYS VISDYLRLGV VSLI
