ID   SLD5_YARLI              Reviewed;         260 AA.
AC   Q6CE80;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA replication complex GINS protein SLD5;
GN   Name=SLD5; Synonyms=TSR3; OrderedLocusNames=YALI0B17820g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC       DNA replication. Has a role in chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC       SLD5, PSF1, PSF2 and PSF3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GINS4/SLD5 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83285.1; -; Genomic_DNA.
DR   RefSeq; XP_501032.1; XM_501032.1.
DR   AlphaFoldDB; Q6CE80; -.
DR   SMR; Q6CE80; -.
DR   STRING; 4952.CAG83285; -.
DR   EnsemblFungi; CAG83285; CAG83285; YALI0_B17820g.
DR   GeneID; 2907214; -.
DR   KEGG; yli:YALI0B17820g; -.
DR   VEuPathDB; FungiDB:YALI0_B17820g; -.
DR   HOGENOM; CLU_071893_2_0_1; -.
DR   InParanoid; Q6CE80; -.
DR   OMA; ILETAWI; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   CDD; cd11711; GINS_A_Sld5; 1.
DR   InterPro; IPR021151; GINS_A.
DR   InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR   InterPro; IPR008591; GINS_Sld5.
DR   InterPro; IPR031633; SLD5_C.
DR   InterPro; IPR038749; Sld5_GINS_A.
DR   PANTHER; PTHR21206; PTHR21206; 1.
DR   Pfam; PF05916; Sld5; 1.
DR   Pfam; PF16922; SLD5_C; 1.
DR   SUPFAM; SSF158573; SSF158573; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..260
FT                   /note="DNA replication complex GINS protein SLD5"
FT                   /id="PRO_0000255435"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  29943 MW;  10FA659DE2BC20F6 CRC64;
     MEEDNLDLEG MDIHSGLDSS FHSPPHTSDP AGLSMDETDD IDDLINNVRP HDPLGTLEEK
     EADIKELTHS WVTERMSPTL LPTKEALLFR ILKRVQLQIE VIEEKSIDMS PDTDVKLELL
     IVETELERIK YLIRSYLRVR LLKIDNSMEY YQSSPLDRMN MSQTERMYLN RHYALLKNLY
     AHQFMNTFPD SLKQMNDSSG SASMVQEPNM DHPVFVRVVK DTGRKIIIGN DSVKLRKGSI
     VVIKYSIIVK YVESGDVVFI