SLD7_YEAS8
ID SLD7_YEAS8 Reviewed; 257 AA.
AC C8ZI21;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Mitochondrial morphogenesis protein SLD7;
DE AltName: Full=Synthetic lethality with DPB11-24 mutation protein 7;
GN Name=SLD7; ORFNames=EC1118_1O4_2608g;
OS Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=643680;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lalvin EC1118 / Prise de mousse;
RX PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC -!- FUNCTION: Required for the proper function of SLD3 at the initiation of
CC DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a
CC component of the replication fork. Required for mitochondrial
CC morphology (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SLD3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLD7 family. {ECO:0000305}.
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DR EMBL; FN394216; CAY86346.1; -; Genomic_DNA.
DR AlphaFoldDB; C8ZI21; -.
DR SMR; C8ZI21; -.
DR EnsemblFungi; CAY86346; CAY86346; EC1118_1O4_2608g.
DR HOGENOM; CLU_072105_0_0_1; -.
DR Proteomes; UP000000286; Chromosome XV, Scaffold EC1118_1O4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR InterPro; IPR016808; Sld7.
DR InterPro; IPR041260; Sld7_C.
DR InterPro; IPR041564; Sld7_N.
DR Pfam; PF18596; Sld7_C; 1.
DR Pfam; PF18636; Sld7_N; 1.
DR PIRSF; PIRSF022788; UCP022788; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cytoplasm; Cytoskeleton; DNA replication; Nucleus.
FT CHAIN 1..257
FT /note="Mitochondrial morphogenesis protein SLD7"
FT /id="PRO_0000411033"
SQ SEQUENCE 257 AA; 29566 MW; 6480B7E5A0E551CD CRC64;
MSRKLCTLNF TLSGKQGSLV IRDIQLWSNR PTASKSTSEL RGQFIQYVDL AKLPLWVRST
NMNTYRCYST SATAQAYFKS KLRNANRGIV IELSDKVDQR SQEPAYLIIF REKTELNCFQ
VDLTMKHEFD GQVTKLKQEI GKTRASVSKE GSIDIIIQQS QQRKIGTKTK VYRNVHINDK
RLQFNETLSK LILGGLRLRG ISNSITDYQK LYKITFDAAE FTHRDELKRI SMGSVEEVSF
ESLQETVETL LKLFTKS