SLD7_YEASL
ID SLD7_YEASL Reviewed; 257 AA.
AC E7KUA5;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 23.
DE RecName: Full=Mitochondrial morphogenesis protein SLD7;
DE AltName: Full=Synthetic lethality with DPB11-24 mutation protein 7;
GN Name=SLD7; ORFNames=QA23_4431;
OS Saccharomyces cerevisiae (strain Lalvin QA23) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=764098;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lalvin QA23;
RX PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA Pretorius I.S., Egholm M., Chambers P.J.;
RT "Whole-genome comparison reveals novel genetic elements that characterize
RT the genome of industrial strains of Saccharomyces cerevisiae.";
RL PLoS Genet. 7:E1001287-E1001287(2011).
CC -!- FUNCTION: Required for the proper function of SLD3 at the initiation of
CC DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a
CC component of the replication fork. Required for mitochondrial
CC morphology (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SLD3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLD7 family. {ECO:0000305}.
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DR EMBL; ADVV01000079; EGA80793.1; -; Genomic_DNA.
DR EnsemblFungi; EGA80793; EGA80793; QA23_4431.
DR HOGENOM; CLU_072105_0_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR InterPro; IPR016808; Sld7.
DR InterPro; IPR041260; Sld7_C.
DR InterPro; IPR041564; Sld7_N.
DR Pfam; PF18596; Sld7_C; 1.
DR Pfam; PF18636; Sld7_N; 1.
DR PIRSF; PIRSF022788; UCP022788; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cytoplasm; Cytoskeleton; DNA replication; Nucleus.
FT CHAIN 1..257
FT /note="Mitochondrial morphogenesis protein SLD7"
FT /id="PRO_0000411035"
SQ SEQUENCE 257 AA; 29564 MW; 7C66545310E55D7B CRC64;
MSRKLCTLNF TLSGKQGSLV IRDIQLWSNR PTASKSTSEL RGQFIQYVDL AKLPLWVRST
NMNTYRCYST SATAQAYFKS KLRNANRGIV IELSDKVDQR SQEPAYLIIF RENTELNCFQ
VDLTMKHEFD GQVTKLKQEI GKTRASVSKE GSIDIIIQQS QQRKIGTKTK VYRNVHINDK
RLQFNETLSK LILGGLRLRG ISNSITDYQK LYKITFDAAE FTHRDELKRI SMGSXEEVSF
ESLQETVETL LKLFTKS