ID   SLD7_YEASO              Reviewed;         257 AA.
AC   E7NND9;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Mitochondrial morphogenesis protein SLD7;
DE   AltName: Full=Synthetic lethality with DPB11-24 mutation protein 7;
GN   Name=SLD7; ORFNames=FOSTERSO_4495;
OS   Saccharomyces cerevisiae (strain FostersO) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=764101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FostersO;
RX   PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA   Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA   Pretorius I.S., Egholm M., Chambers P.J.;
RT   "Whole-genome comparison reveals novel genetic elements that characterize
RT   the genome of industrial strains of Saccharomyces cerevisiae.";
RL   PLoS Genet. 7:E1001287-E1001287(2011).
CC   -!- FUNCTION: Required for the proper function of SLD3 at the initiation of
CC       DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a
CC       component of the replication fork. Required for mitochondrial
CC       morphology (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SLD3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle pole {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLD7 family. {ECO:0000305}.
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DR   EMBL; AEEZ01000095; EGA60430.1; -; Genomic_DNA.
DR   PRIDE; E7NND9; -.
DR   EnsemblFungi; EGA60430; EGA60430; FOSTERSO_4495.
DR   HOGENOM; CLU_072105_0_0_1; -.
DR   OMA; EFTHRDE; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR016808; Sld7.
DR   InterPro; IPR041260; Sld7_C.
DR   InterPro; IPR041564; Sld7_N.
DR   Pfam; PF18596; Sld7_C; 1.
DR   Pfam; PF18636; Sld7_N; 1.
DR   PIRSF; PIRSF022788; UCP022788; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; Cytoskeleton; DNA replication; Nucleus.
FT   CHAIN           1..257
FT                   /note="Mitochondrial morphogenesis protein SLD7"
FT                   /id="PRO_0000411036"
SQ   SEQUENCE   257 AA;  29542 MW;  1BB40FF02B8C3E94 CRC64;
     MSRKLCTLNF TLSGKQGSLV IRDIQLWSNR PTASKSTSEX RGQFIQYVDL AKLPLWVRST
     NMNTYRCYST SATAQAYFKS KLRNANRGIV IELXDKVDQR SQEPAYLIIF RENTELNCFQ
     VDLTMKHEFD GQVTKLKQDI GKTRASVSKE GSIDIIIQQX QQRKIGTKTK VYRNVHINDK
     RLQFNETLSK LILGGLRLRG ISNSITDYQK LYKITFDAAE FTHRDELKRI SMGSGEEVSF
     ESLQETVETL LKLFTKS