ID   BI1_PAROL               Reviewed;         237 AA.
AC   Q9IA79;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   11-DEC-2019, entry version 54.
DE   RecName: Full=Probable Bax inhibitor 1;
DE            Short=BI-1;
DE   AltName: Full=Testis-enhanced gene transcript protein homolog;
DE   AltName: Full=Transmembrane BAX inhibitor motif-containing protein 6;
GN   Name=tmbim6; Synonyms=tegt;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Lee J., Jeon J., Song Y.;
RT   "Liver cDNA from Japanese flounder with similarity to TEGT.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Suppressor of apoptosis. Modulates unfolded protein response
CC       signaling. Modulate ER calcium homeostasis by acting as a calcium-leak
CC       channel (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly abundant in testis.
CC   -!- DOMAIN: The intra-membrane loop at the C-terminus acts as a calcium
CC       pore, mediating calcium leak from the ER into the cytosol.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
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DR   EMBL; AF220548; AAF61067.1; -; mRNA.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR   InterPro; IPR006213; Bax_inhbtr1_CS.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
DR   PROSITE; PS01243; BI1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Calcium; Endoplasmic reticulum; Membrane; Transmembrane;
KW   Transmembrane helix; Unfolded protein response.
FT   CHAIN           1..237
FT                   /note="Probable Bax inhibitor 1"
FT                   /id="PRO_0000179083"
FT   TOPO_DOM        1..29
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..52
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..112
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..166
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..206
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   237 AA;  26571 MW;  344181AA386AB9A6 CRC64;
     MNVFDRNINF DSLFKFSQIS HSTQVHLKNV YSSLAVCMFV AAAGSYVHVV TRLFQGGMLS
     VLGSLGMMFW LAMTPHNSET EKKRLAILAG FAFLTGVGLC PTLDFVIAIN PSIIVTAFLG
     TSVIFVCFTL SALYAKRRSY LFLGGTLMSG LSILFLMSMM NMFFGSVMLF KAHMYLGLLI
     MCGFVLXDTQ LIIEKAENGD KDYVWHSVDL FLDFITIFRK LMVILALNDK DKKKEKK