ID   SLFN5_MOUSE             Reviewed;         884 AA.
AC   Q8CBA2; Q148Z1; Q3V3H0; Q5QNT5; Q7TMA8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Schlafen family member 5;
GN   Name=Slfn5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=129/SvJ, and C57BL/6J;
RX   PubMed=15351786; DOI=10.1093/intimm/dxh155;
RA   Geserick P., Kaiser F., Klemm U., Kaufmann S.H.E., Zerrahn J.;
RT   "Modulation of T cell development and activation by novel members of the
RT   Schlafen (slfn) gene family harbouring an RNA helicase-like motif.";
RL   Int. Immunol. 16:1535-1548(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May have a role in hematopoietic cell differentiation.
CC       {ECO:0000269|PubMed:15351786}.
CC   -!- SIMILARITY: Belongs to the Schlafen family. Subgroup III subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY261804; AAP30074.1; -; mRNA.
DR   EMBL; AY261805; AAP30075.1; -; mRNA.
DR   EMBL; AK036486; BAC29447.1; -; mRNA.
DR   EMBL; AK040359; BAE20578.1; -; mRNA.
DR   EMBL; AL603745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC117909; AAI17910.1; -; mRNA.
DR   EMBL; BC117910; AAI17911.1; -; mRNA.
DR   CCDS; CCDS25153.1; -.
DR   RefSeq; NP_899024.3; NM_183201.4.
DR   RefSeq; XP_006533637.1; XM_006533574.2.
DR   RefSeq; XP_006533642.1; XM_006533579.1.
DR   RefSeq; XP_006533643.1; XM_006533580.1.
DR   RefSeq; XP_017170104.1; XM_017314615.1.
DR   RefSeq; XP_017170105.1; XM_017314616.1.
DR   RefSeq; XP_017170106.1; XM_017314617.1.
DR   RefSeq; XP_017170107.1; XM_017314618.1.
DR   AlphaFoldDB; Q8CBA2; -.
DR   SMR; Q8CBA2; -.
DR   BioGRID; 236519; 2.
DR   STRING; 10090.ENSMUSP00000064819; -.
DR   iPTMnet; Q8CBA2; -.
DR   PhosphoSitePlus; Q8CBA2; -.
DR   EPD; Q8CBA2; -.
DR   jPOST; Q8CBA2; -.
DR   MaxQB; Q8CBA2; -.
DR   PaxDb; Q8CBA2; -.
DR   PeptideAtlas; Q8CBA2; -.
DR   PRIDE; Q8CBA2; -.
DR   ProteomicsDB; 261079; -.
DR   Antibodypedia; 2910; 26 antibodies from 15 providers.
DR   DNASU; 327978; -.
DR   Ensembl; ENSMUST00000067443; ENSMUSP00000064819; ENSMUSG00000054404.
DR   Ensembl; ENSMUST00000108157; ENSMUSP00000103792; ENSMUSG00000054404.
DR   GeneID; 327978; -.
DR   KEGG; mmu:327978; -.
DR   UCSC; uc007knz.2; mouse.
DR   CTD; 162394; -.
DR   MGI; MGI:1329004; Slfn5.
DR   VEuPathDB; HostDB:ENSMUSG00000054404; -.
DR   eggNOG; ENOG502QWKG; Eukaryota.
DR   GeneTree; ENSGT00410000025651; -.
DR   HOGENOM; CLU_007071_0_0_1; -.
DR   InParanoid; Q8CBA2; -.
DR   OMA; NGYSPRD; -.
DR   OrthoDB; 211385at2759; -.
DR   PhylomeDB; Q8CBA2; -.
DR   TreeFam; TF337168; -.
DR   BioGRID-ORCS; 327978; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Slfn5; mouse.
DR   PRO; PR:Q8CBA2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8CBA2; protein.
DR   Bgee; ENSMUSG00000054404; Expressed in hindlimb stylopod muscle and 96 other tissues.
DR   ExpressionAtlas; Q8CBA2; baseline and differential.
DR   Genevisible; Q8CBA2; MM.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.950.30; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029684; Schlafen.
DR   InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR   InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR   InterPro; IPR029671; Slfn5.
DR   InterPro; IPR018647; SLFN_3-like_DNA/RNA_helicase.
DR   PANTHER; PTHR12155; PTHR12155; 1.
DR   PANTHER; PTHR12155:SF26; PTHR12155:SF26; 1.
DR   Pfam; PF04326; AlbA_2; 1.
DR   Pfam; PF09848; DUF2075; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Differentiation; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..884
FT                   /note="Schlafen family member 5"
FT                   /id="PRO_0000282983"
FT   BINDING         574..581
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        193
FT                   /note="F -> I (in Ref. 4; AAI17911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        515
FT                   /note="I -> T (in Ref. 1; AAP30074/AAP30075)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        518
FT                   /note="Q -> K (in Ref. 1; AAP30074/AAP30075)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        601
FT                   /note="N -> D (in Ref. 1; AAP30074/AAP30075)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        713
FT                   /note="T -> A (in Ref. 2; BAC29447)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   884 AA;  100819 MW;  2F96393344CDA849 CRC64;
     MSFLEDLELN FAECIQDGGK ATLGVRQREE MDTTHCMKQN EIISQAVCAL LNSGGGVVRV
     EIENGDYNFE RDGVGLNLPP LFRNHLDEML YGKLFLIYVS SWDVAASHVR LATLCSNLYH
     RCGTFTEVMD PEKALKFLKR VQDPRILGDS DSLNLQEAPV DDAQMILASD LFHSPQLQYL
     EKLNFTKSSH VEFQMFSADL SQGIRERLPK CVSALANSEG GYVFFGVHDE TRHVIGCEKE
     KINCTNLKST IDACIRKMPV YHFCGQNHKV QYELKFLEVY DKEALHGYVC AIKVERFCCA
     AFAKAPDSWE IKDNNKKPLT ANDWASRMIE INPDLSSFPQ MIPWKSMLNT TPCSKTVFTH
     KYLKCVEDLQ KDYFPVSPNR ITYTPESVYK DLFADYRGLR NLINMEMRCF SQGILIFSHS
     WAVDLGLQRR QDVICDALLI SPNNVPILYT ICNKWDLGNR HYSMKVARTL KQKLVNMGGY
     PGRLGIIPLV LPLGSHQRVR NDLEMPVYPE SYNFITTQQV EALLQSLVII LFGFRPLLNE
     ELNLESETVA LLSDQQYGLL STNLSKHREM FVHGLPGSGK TTLALMIVGK IRNVFNCQAD
     NILYICENQS LKRFIVRKNV CQAVTRKTFM KNTFDNVQHI IVDEAQNFRT EDGNWYAKAK
     AITQRARDGP GVLYIFLDYF QINHLCCSGL PELQHQKPLL KLTRMLRSGD NITSYLQDIM
     HQIRENPPPN VPQEALMVGE ELEWGPDVTG NLEITDNLNL EQMSVYVAEK CQSLWRSGYF
     TDVAVLFTRA RDIEKCRDKL LLAMRRRSMS QLAEEPSLLV QVREGLDSLG SHVVLESVHR
     FSGMERSIVF GIIPMGSETA IFYNALLCLA SRARTHLYIV KVVF