SLI1_YEAST
ID SLI1_YEAST Reviewed; 468 AA.
AC P53304; D6VUZ5;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=N-acetyltransferase SLI1;
DE EC=2.3.1.-;
DE AltName: Full=Sphingosine-like immunosuppressant resistant protein 1;
GN Name=SLI1; OrderedLocusNames=YGR212W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9290212;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT chromosome VII.";
RL Yeast 13:1077-1090(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15025559; DOI=10.1042/bj20040108;
RA Momoi M., Tanoue D., Sun Y., Takematsu H., Suzuki Y., Suzuki M., Suzuki A.,
RA Fujita T., Kozutsumi Y.;
RT "SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid
RT biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in
RT yeast.";
RL Biochem. J. 381:321-328(2004).
CC -!- FUNCTION: Confers resistance to the sphingolipid biosynthesis inhibitor
CC drug myriocin (ISP-1). Inactivates ISP-1 by converting it into N-
CC acetyl-myriocin. Cooperates with YPK1 in mediating resistance to
CC myriocin. {ECO:0000269|PubMed:15025559}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:15025559}.
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DR EMBL; Z72997; CAA97239.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08306.1; -; Genomic_DNA.
DR PIR; S64535; S64535.
DR RefSeq; NP_011728.3; NM_001181341.3.
DR AlphaFoldDB; P53304; -.
DR BioGRID; 33465; 53.
DR IntAct; P53304; 1.
DR STRING; 4932.YGR212W; -.
DR iPTMnet; P53304; -.
DR PaxDb; P53304; -.
DR PRIDE; P53304; -.
DR EnsemblFungi; YGR212W_mRNA; YGR212W; YGR212W.
DR GeneID; 853126; -.
DR KEGG; sce:YGR212W; -.
DR SGD; S000003444; SLI1.
DR VEuPathDB; FungiDB:YGR212W; -.
DR eggNOG; ENOG502RC91; Eukaryota.
DR HOGENOM; CLU_599872_0_0_1; -.
DR InParanoid; P53304; -.
DR OMA; NLHSCFY; -.
DR BioCyc; YEAST:G3O-30894-MON; -.
DR PRO; PR:P53304; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53304; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0008080; F:N-acetyltransferase activity; IDA:SGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IDA:SGD.
DR InterPro; IPR010828; Atf2/Sli1-like.
DR Pfam; PF07247; AATase; 1.
PE 4: Predicted;
KW Acyltransferase; Endoplasmic reticulum; Reference proteome; Transferase.
FT CHAIN 1..468
FT /note="N-acetyltransferase SLI1"
FT /id="PRO_0000202846"
SQ SEQUENCE 468 AA; 54473 MW; 7E51F344C74E51B1 CRC64;
MNLKLSAIES YFFHRSRLNL HSCFYVGIKL NELPKKSQLI AALKYTVIQH ERLTCNVFYD
ELKKENFLQN ILEPLKFCDL VEYRHDWDQL GETEINHIFQ RYNFSYNENK PLWKILILPN
QNQMLLLTDH VLMDGMSAIH VWETFMEGLQ MQQPVEIDET IYSPSLNSST EKIMSAPLYG
DWPIPWNWHI VRQLVSRLHY WFPQTVVKNN RNLIQFANYS FPKDLLDDKP SDGTQKYKVK
NTNHQWEFRL SPTHLNDILQ ECKANNTSLT SLLGALVCTS FEKIAAHEYT GSFLKIELPM
NIRKPFERVL KLPSDDKLAV GNFIAVIEFN HKLHQNRGIW DIASQIQRAI RSSSEDKIID
KVNEVKLLEV ISSQQYIEDK ISLNNGPSST FEVTNLGFQT FKDACNTSLP FYIVDATFNE
PQGISSIFSL SVISTPGNGL HCCISYPNTL TKVLEPHWQY MKDYLNLY
