ID   SLIB_BOVIN              Reviewed;         106 AA.
AC   P63292; P01288; Q9MZD4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Somatoliberin;
DE   AltName: Full=Growth hormone-releasing factor;
DE            Short=GRF;
DE   AltName: Full=Growth hormone-releasing hormone;
DE            Short=GHRH;
DE   Flags: Precursor;
GN   Name=GHRH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhou P., Kazmer G.W., Yang X.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 31-74, AND AMIDATION AT LEU-74.
RX   PubMed=6421287; DOI=10.1016/0006-291x(83)91664-9;
RA   Esch F., Boehlen P., Ling N., Brazeau P., Guillemin R.;
RT   "Isolation and characterization of the bovine hypothalamic growth hormone
RT   releasing factor.";
RL   Biochem. Biophys. Res. Commun. 117:772-779(1983).
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; AF242855; AAF89171.1; -; Genomic_DNA.
DR   PIR; A01554; RHBOS.
DR   RefSeq; NP_847895.1; NM_178325.1.
DR   AlphaFoldDB; P63292; -.
DR   BMRB; P63292; -.
DR   SMR; P63292; -.
DR   STRING; 9913.ENSBTAP00000016891; -.
DR   PaxDb; P63292; -.
DR   Ensembl; ENSBTAT00000016891; ENSBTAP00000016891; ENSBTAG00000012710.
DR   GeneID; 281191; -.
DR   KEGG; bta:281191; -.
DR   CTD; 2691; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012710; -.
DR   VGNC; VGNC:29349; GHRH.
DR   eggNOG; ENOG502S2N6; Eukaryota.
DR   GeneTree; ENSGT00950000183154; -.
DR   HOGENOM; CLU_174932_0_0_1; -.
DR   InParanoid; P63292; -.
DR   OMA; WTDQKQV; -.
DR   OrthoDB; 1445692at2759; -.
DR   TreeFam; TF353187; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000012710; Expressed in anterior segment of eyeball and 20 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR   GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR   GO; GO:0016608; F:growth hormone-releasing hormone activity; IMP:CAFA.
DR   GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0071277; P:cellular response to calcium ion; IMP:CAFA.
DR   GO; GO:0030252; P:growth hormone secretion; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IMP:UniProtKB.
DR   GO; GO:0060124; P:positive regulation of growth hormone secretion; IMP:AgBase.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IMP:AgBase.
DR   GO; GO:1903489; P:positive regulation of lactation; IMP:AgBase.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IBA:GO_Central.
DR   GO; GO:0032094; P:response to food; IEA:Ensembl.
DR   DisProt; DP00125; -.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..30
FT                   /evidence="ECO:0000269|PubMed:6421287"
FT                   /id="PRO_0000011435"
FT   PEPTIDE         31..74
FT                   /note="Somatoliberin"
FT                   /id="PRO_0000011436"
FT   PROPEP          77..106
FT                   /id="PRO_0000011437"
FT   MOD_RES         74
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:6421287"
SQ   SEQUENCE   106 AA;  12058 MW;  6584F4F25ABEF178 CRC64;
     MLLWVFFLVT LTLSSGSHGS LPSQPLRIPR YADAIFTNSY RKVLGQLSAR KLLQDIMNRQ
     QGERNQEQGA KVRLGRQVDG VWTDQQQMAL ESTLVSLLQE RRNSQG