ID   SLIB_CYPCA              Reviewed;          45 AA.
AC   P42692;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Somatoliberin;
DE   AltName: Full=Growth hormone-releasing factor;
DE            Short=GRF;
DE   AltName: Full=Growth hormone-releasing hormone;
DE            Short=GHRH;
GN   Name=ghrh;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   PROTEIN SEQUENCE, AND SYNTHESIS.
RC   TISSUE=Hypothalamus;
RX   PubMed=1475012; DOI=10.1159/000126272;
RA   Vaughan J.M., Rivier J., Spiess J., Peng C., Chang J.P., Peter R.E.,
RA   Vale W.;
RT   "Isolation and characterization of hypothalamic growth-hormone releasing
RT   factor from common carp, Cyprinus carpio.";
RL   Neuroendocrinology 56:539-549(1992).
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P42692; -.
DR   SMR; P42692; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016521; F:pituitary adenylate cyclase activating polypeptide activity; IEA:InterPro.
DR   GO; GO:0031858; F:pituitary adenylate cyclase-activating polypeptide receptor binding; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR   GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR039080; PACAP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   PANTHER; PTHR11213:SF1; PTHR11213:SF1; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Secreted.
FT   CHAIN           1..45
FT                   /note="Somatoliberin"
FT                   /id="PRO_0000148923"
SQ   SEQUENCE   45 AA;  4979 MW;  67C9E8A06B24AE94 CRC64;
     HADGMFNKAY RKALGQLSAR KYLHTLMAKR VGGGSMIEDD NEPLS