ID   SLIB_MESAU              Reviewed;         107 AA.
AC   Q60549;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Somatoliberin;
DE   AltName: Full=Growth hormone-releasing factor;
DE            Short=GRF;
DE   AltName: Full=Growth hormone-releasing hormone;
DE            Short=GHRH;
DE   Flags: Precursor;
GN   Name=GHRH; Synonyms=GRF;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=7703510; DOI=10.3109/10425179409039710;
RA   Ono M., Miki N., Demura H., Tadokoro K., Nagafuchi S., Yamada M.;
RT   "Molecular cloning of cDNA encoding the precursor for hamster hypothalamic
RT   growth hormone-releasing factor.";
RL   DNA Seq. 5:93-102(1994).
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; D23671; BAA04901.1; -; mRNA.
DR   RefSeq; NP_001268519.1; NM_001281590.1.
DR   AlphaFoldDB; Q60549; -.
DR   SMR; Q60549; -.
DR   STRING; 10036.XP_005084652.1; -.
DR   GeneID; 101834855; -.
DR   CTD; 2691; -.
DR   eggNOG; ENOG502S2N6; Eukaryota.
DR   OrthoDB; 1445692at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..30
FT                   /id="PRO_0000011441"
FT   PEPTIDE         31..74
FT                   /note="Somatoliberin"
FT                   /id="PRO_0000011442"
FT   PROPEP          77..107
FT                   /id="PRO_0000011443"
FT   MOD_RES         74
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   107 AA;  12298 MW;  3DEFA8D4B3F37636 CRC64;
     MPLWVFFVIL TLTNGSHCSP SPSLPFRIRR YADAIFTSSY RKVLGQLSAR KLLQDIMSRQ
     QGERNQEQGP RVRLGRQVDS MWADHRQMSL ESLLAALLQK HSRDSQG