SLIB_MOUSE
ID SLIB_MOUSE Reviewed; 103 AA.
AC P16043;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Somatoliberin;
DE AltName: Full=Growth hormone-releasing factor;
DE Short=GRF;
DE AltName: Full=Growth hormone-releasing hormone;
DE Short=GHRH;
DE Flags: Precursor;
GN Name=Ghrh;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2514346; DOI=10.1210/mend-3-11-1693;
RA Suhr S.T., Rahal J.O., Mayo K.E.;
RT "Mouse growth-hormone-releasing hormone: precursor structure and expression
RT in brain and placenta.";
RL Mol. Endocrinol. 3:1693-1700(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2481813; DOI=10.1210/mend-3-10-1529;
RA Frohman M.A., Downs T.R., Chomczynski P., Frohman L.A.;
RT "Cloning and characterization of mouse growth hormone-releasing hormone
RT (GRH) complementary DNA: increased GRH messenger RNA levels in the growth
RT hormone-deficient lit/lit mouse.";
RL Mol. Endocrinol. 3:1529-1536(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; M31654; AAA37691.1; -; mRNA.
DR EMBL; M31658; AAA37739.1; -; mRNA.
DR EMBL; AK018796; BAB31418.1; -; mRNA.
DR EMBL; BC068204; AAH68204.1; -; mRNA.
DR CCDS; CCDS16976.1; -.
DR PIR; A41410; A41410.
DR RefSeq; NP_001316612.1; NM_001329683.1.
DR RefSeq; NP_034415.1; NM_010285.3.
DR AlphaFoldDB; P16043; -.
DR SMR; P16043; -.
DR BioGRID; 199916; 2.
DR STRING; 10090.ENSMUSP00000029172; -.
DR PaxDb; P16043; -.
DR PRIDE; P16043; -.
DR Antibodypedia; 11938; 288 antibodies from 25 providers.
DR DNASU; 14601; -.
DR Ensembl; ENSMUST00000029172; ENSMUSP00000029172; ENSMUSG00000027643.
DR Ensembl; ENSMUST00000109536; ENSMUSP00000105162; ENSMUSG00000027643.
DR GeneID; 14601; -.
DR KEGG; mmu:14601; -.
DR UCSC; uc008nox.1; mouse.
DR CTD; 2691; -.
DR MGI; MGI:95709; Ghrh.
DR VEuPathDB; HostDB:ENSMUSG00000027643; -.
DR eggNOG; ENOG502S2N6; Eukaryota.
DR GeneTree; ENSGT00950000183154; -.
DR HOGENOM; CLU_174932_0_0_1; -.
DR InParanoid; P16043; -.
DR OMA; WTDQKQV; -.
DR OrthoDB; 1445692at2759; -.
DR PhylomeDB; P16043; -.
DR TreeFam; TF353187; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR BioGRID-ORCS; 14601; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ghrh; mouse.
DR PRO; PR:P16043; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P16043; protein.
DR Bgee; ENSMUSG00000027643; Expressed in placenta labyrinth and 41 other tissues.
DR ExpressionAtlas; P16043; baseline and differential.
DR Genevisible; P16043; MM.
DR GO; GO:0043679; C:axon terminus; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0043204; C:perikaryon; ISO:MGI.
DR GO; GO:0043195; C:terminal bouton; IDA:MGI.
DR GO; GO:0016608; F:growth hormone-releasing hormone activity; ISO:MGI.
DR GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; IPI:BHF-UCL.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0042748; P:circadian sleep/wake cycle, non-REM sleep; ISO:MGI.
DR GO; GO:0030252; P:growth hormone secretion; IDA:MGI.
DR GO; GO:0046879; P:hormone secretion; IMP:MGI.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; ISO:MGI.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:BHF-UCL.
DR GO; GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; ISO:MGI.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IMP:MGI.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0032094; P:response to food; IDA:MGI.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..30
FT /id="PRO_0000011444"
FT PEPTIDE 31..72
FT /note="Somatoliberin"
FT /id="PRO_0000011445"
FT PROPEP 74..103
FT /id="PRO_0000011446"
SQ SEQUENCE 103 AA; 12064 MW; F3BA6870BF2CA8DC CRC64;
MLLWVLFVIL ILTSGSHCSL PPSPPFRMQR HVDAIFTTNY RKLLSQLYAR KVIQDIMNKQ
GERIQEQRAR LSRQEDSMWT EDKQMTLESI LQGFPRMKPS ADA
