ID   SLIB_PIG                Reviewed;          44 AA.
AC   P01287;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Somatoliberin;
DE   AltName: Full=Growth hormone-releasing factor;
DE            Short=GRF;
DE   AltName: Full=Growth hormone-releasing hormone;
DE            Short=GHRH;
GN   Name=GHRH;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-44.
RC   TISSUE=Hypothalamus;
RX   PubMed=6418166; DOI=10.1016/0006-291x(83)90585-5;
RA   Boehlen P., Esch F., Brazeau P., Ling N., Guillemin R.;
RT   "Isolation and characterization of the porcine hypothalamic growth hormone
RT   releasing factor.";
RL   Biochem. Biophys. Res. Commun. 116:726-734(1983).
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: The carboxyl-amidated somatoliberin is twice as active
CC       as that having a free carboxyl end.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A01553; RHPG.
DR   AlphaFoldDB; P01287; -.
DR   BMRB; P01287; -.
DR   SMR; P01287; -.
DR   STRING; 9823.ENSSSCP00000007809; -.
DR   PaxDb; P01287; -.
DR   eggNOG; ENOG502S2N6; Eukaryota.
DR   HOGENOM; CLU_174932_0_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR   GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR   GO; GO:0016608; F:growth hormone-releasing hormone activity; IBA:GO_Central.
DR   GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0030252; P:growth hormone secretion; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0060124; P:positive regulation of growth hormone secretion; IBA:GO_Central.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IBA:GO_Central.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Reference proteome; Secreted.
FT   CHAIN           1..44
FT                   /note="Somatoliberin"
FT                   /id="PRO_0000148921"
FT   MOD_RES         44
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:6418166"
SQ   SEQUENCE   44 AA;  5110 MW;  1271DC7059F4802E CRC64;
     YADAIFTNSY RKVLGQLSAR KLLQDIMSRQ QGERNQEQGA RVRL