SLIB_RAT
ID SLIB_RAT Reviewed; 104 AA.
AC P09916;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Somatoliberin;
DE AltName: Full=Growth hormone-releasing factor;
DE Short=GRF;
DE AltName: Full=Growth hormone-releasing hormone;
DE Short=GHRH;
DE Flags: Precursor;
GN Name=Ghrh;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3920534; DOI=10.1038/314464a0;
RA Mayo K.E., Cerelli G.M., Rosenfeld M.G., Evans R.M.;
RT "Characterization of cDNA and genomic clones encoding the precursor to rat
RT hypothalamic growth hormone-releasing factor.";
RL Nature 314:464-467(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1924334; DOI=10.1073/pnas.88.19.8749;
RA Gonzalez-Crespo S., Boronat A.;
RT "Expression of the rat growth hormone-releasing hormone gene in placenta is
RT directed by an alternative promoter.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:8749-8753(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=7895659; DOI=10.1210/endo.136.4.7895659;
RA Srivastava C.H., Monts B.S., Rothrock J.K., Peredo M.J., Pescovitz O.H.;
RT "Presence of a spermatogenic-specific promoter in the rat growth hormone-
RT releasing hormone gene.";
RL Endocrinology 136:1502-1508(1995).
RN [4]
RP PROTEIN SEQUENCE OF 31-73.
RC TISSUE=Hypothalamus;
RX PubMed=6406907; DOI=10.1038/303532a0;
RA Spiees J., Rivier J., Vale W.;
RT "Characterization of rat hypothalamic growth hormone-releasing factor.";
RL Nature 303:532-535(1983).
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; X02319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X02335; CAA26194.1; -; Genomic_DNA.
DR EMBL; X02320; CAA26194.1; JOINED; Genomic_DNA.
DR EMBL; X02321; CAA26194.1; JOINED; Genomic_DNA.
DR EMBL; X02322; CAA26194.1; JOINED; Genomic_DNA.
DR EMBL; M73486; AAA41220.1; -; mRNA.
DR EMBL; U10156; AAC52184.1; -; mRNA.
DR PIR; A32731; A32731.
DR RefSeq; NP_113765.1; NM_031577.1.
DR RefSeq; XP_008760526.1; XM_008762304.1.
DR AlphaFoldDB; P09916; -.
DR SMR; P09916; -.
DR STRING; 10116.ENSRNOP00000010298; -.
DR PaxDb; P09916; -.
DR Ensembl; ENSRNOT00000010443; ENSRNOP00000010444; ENSRNOG00000007782.
DR GeneID; 29446; -.
DR KEGG; rno:29446; -.
DR CTD; 2691; -.
DR RGD; 61883; Ghrh.
DR eggNOG; ENOG502S2N6; Eukaryota.
DR GeneTree; ENSGT00950000183154; -.
DR InParanoid; P09916; -.
DR OMA; WTDQKQV; -.
DR OrthoDB; 1445692at2759; -.
DR Reactome; R-RNO-420092; Glucagon-type ligand receptors.
DR PRO; PR:P09916; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000007782; Expressed in testis and 3 other tissues.
DR ExpressionAtlas; P09916; baseline and differential.
DR Genevisible; P09916; RN.
DR GO; GO:0043679; C:axon terminus; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:0043204; C:perikaryon; IDA:RGD.
DR GO; GO:0043195; C:terminal bouton; ISO:RGD.
DR GO; GO:0016608; F:growth hormone-releasing hormone activity; IDA:RGD.
DR GO; GO:0031770; F:growth hormone-releasing hormone receptor binding; ISO:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR GO; GO:0021984; P:adenohypophysis development; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:RGD.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IDA:RGD.
DR GO; GO:0071354; P:cellular response to interleukin-6; IEP:RGD.
DR GO; GO:0042748; P:circadian sleep/wake cycle, non-REM sleep; IDA:RGD.
DR GO; GO:0030252; P:growth hormone secretion; IMP:RGD.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IMP:RGD.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; IMP:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IDA:RGD.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:RGD.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:RGD.
DR GO; GO:0071548; P:response to dexamethasone; IEP:RGD.
DR GO; GO:0032094; P:response to food; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR GO; GO:0044321; P:response to leptin; IEP:RGD.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11213; PTHR11213; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..30
FT /evidence="ECO:0000269|PubMed:6406907"
FT /id="PRO_0000011447"
FT PEPTIDE 31..73
FT /note="Somatoliberin"
FT /id="PRO_0000011448"
FT PROPEP 75..104
FT /id="PRO_0000011449"
SQ SEQUENCE 104 AA; 12266 MW; F9C17485742B2887 CRC64;
MPLWVFFVLL TLTSGSHCSL PPSPPFRVRR HADAIFTSSY RRILGQLYAR KLLHEIMNRQ
QGERNQEQRS RFNRHLDRVW AEDKQMALES ILQGFPRMKL SAEA
