ID   SLIB_SHEEP              Reviewed;          44 AA.
AC   P07217;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Somatoliberin;
DE   AltName: Full=Growth hormone-releasing factor;
DE            Short=GRF;
DE   AltName: Full=Growth hormone-releasing hormone;
DE            Short=GHRH;
GN   Name=GHRH;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT LEU-44.
RX   PubMed=6440561; DOI=10.1016/0006-291x(84)90582-5;
RA   Brazeau P., Boehlen P., Esch F., Ling N., Wehrenberg W.B., Guillemin R.;
RT   "Growth hormone-releasing factor from ovine and caprine hypothalamus:
RT   isolation, sequence analysis and total synthesis.";
RL   Biochem. Biophys. Res. Commun. 125:606-614(1984).
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P07217; -.
DR   SMR; P07217; -.
DR   STRING; 9940.ENSOARP00000019136; -.
DR   eggNOG; ENOG502S2N6; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11213; PTHR11213; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Reference proteome; Secreted.
FT   CHAIN           1..44
FT                   /note="Somatoliberin"
FT                   /id="PRO_0000148922"
FT   MOD_RES         44
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:6440561"
SQ   SEQUENCE   44 AA;  5123 MW;  9F907C6769F48030 CRC64;
     YADAIFTNSY RKILGQLSAR KLLQDIMNRQ QGERNQEQGA KVRL