SLIK1_MOUSE
ID SLIK1_MOUSE Reviewed; 696 AA.
AC Q810C1; Q9CXL0;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=SLIT and NTRK-like protein 1;
DE Flags: Precursor;
GN Name=Slitrk1; Synonyms=Sltk1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:BAC67204.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=14550773; DOI=10.1016/s1044-7431(03)00129-5;
RA Aruga J., Mikoshiba K.;
RT "Identification and characterization of Slitrk, a novel neuronal
RT transmembrane protein family controlling neurite outgrowth.";
RL Mol. Cell. Neurosci. 24:117-129(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-696.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=27273464; DOI=10.1038/srep27343;
RA Beaubien F., Raja R., Kennedy T.E., Fournier A.E., Cloutier J.F.;
RT "Slitrk1 is localized to excitatory synapses and promotes their
RT development.";
RL Sci. Rep. 6:27343-27343(2016).
CC -!- FUNCTION: It is involved in synaptogenesis and promotes excitatory
CC synapse differentiation (By similarity). Enhances neuronal dendrite
CC outgrowth (PubMed:14550773). {ECO:0000250|UniProtKB:Q96PX8,
CC ECO:0000269|PubMed:14550773}.
CC -!- SUBUNIT: Can form homodimers; homodimerization requires repeat LRR 2
CC (By similarity). Interacts with YWHAB, YWHAE, YWHAG, YWHAH, SFN, YWHAQ
CC and YWHAZ (By similarity). {ECO:0000250|UniProtKB:Q96PX8}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q96PX8}; Single-
CC pass type I membrane protein {ECO:0000250|UniProtKB:Q96PX8}. Secreted
CC {ECO:0000250|UniProtKB:Q96PX8}. Synapse {ECO:0000269|PubMed:27273464}.
CC -!- TISSUE SPECIFICITY: In the adult, significant expression is detected
CC only in the brain. Broadly expressed in embryonic brain with highest
CC expression in subventricular zone, subplate, cortical plate, pyramidal
CC cell layer of hippocampus, thalamus and hypothalamus where levels are
CC highest in ventromedial hypothalamus and medial part of periaqueductal
CC gray matter. Also expressed in mantle layer of spinal cord and in
CC lateral and medial motor columns. {ECO:0000269|PubMed:14550773}.
CC -!- DEVELOPMENTAL STAGE: In the embryo, expressed from day 10-12 and
CC continues through later gestational development and into adulthood.
CC {ECO:0000269|PubMed:14550773}.
CC -!- PTM: Undergoes proteolytic cleavage that results in shedding of the
CC ectodomain and cleavage of the C-terminal cytoplasmic tail.
CC Glycosylated. Phosphorylation at Ser-695 is necessary for proper
CC function in promoting neurite outgrowth.
CC {ECO:0000250|UniProtKB:Q96PX8}.
CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
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DR EMBL; AB097570; BAC67204.1; -; Genomic_DNA.
DR EMBL; AK014285; BAB29244.2; -; mRNA.
DR CCDS; CCDS27325.1; -.
DR RefSeq; NP_951020.1; NM_199065.2.
DR AlphaFoldDB; Q810C1; -.
DR SMR; Q810C1; -.
DR STRING; 10090.ENSMUSP00000097897; -.
DR iPTMnet; Q810C1; -.
DR PhosphoSitePlus; Q810C1; -.
DR MaxQB; Q810C1; -.
DR PaxDb; Q810C1; -.
DR PRIDE; Q810C1; -.
DR ProteomicsDB; 258690; -.
DR Antibodypedia; 2648; 268 antibodies from 31 providers.
DR DNASU; 76965; -.
DR Ensembl; ENSMUST00000100322; ENSMUSP00000097897; ENSMUSG00000075478.
DR GeneID; 76965; -.
DR KEGG; mmu:76965; -.
DR UCSC; uc007uyc.1; mouse.
DR CTD; 114798; -.
DR MGI; MGI:2679446; Slitrk1.
DR VEuPathDB; HostDB:ENSMUSG00000075478; -.
DR eggNOG; ENOG502QTHH; Eukaryota.
DR GeneTree; ENSGT00940000159810; -.
DR HOGENOM; CLU_012706_2_0_1; -.
DR InParanoid; Q810C1; -.
DR OMA; ETCDPGP; -.
DR OrthoDB; 217854at2759; -.
DR PhylomeDB; Q810C1; -.
DR TreeFam; TF351826; -.
DR Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases.
DR BioGRID-ORCS; 76965; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Slitrk1; mouse.
DR PRO; PR:Q810C1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q810C1; protein.
DR Bgee; ENSMUSG00000075478; Expressed in lateral septal nucleus and 138 other tissues.
DR ExpressionAtlas; Q810C1; baseline and differential.
DR Genevisible; Q810C1; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0098982; C:GABA-ergic synapse; ISO:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IDA:SynGO.
DR GO; GO:0045202; C:synapse; IDA:UniProtKB.
DR GO; GO:0030534; P:adult behavior; IMP:MGI.
DR GO; GO:0007409; P:axonogenesis; IDA:MGI.
DR GO; GO:0042592; P:homeostatic process; IMP:MGI.
DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR GO; GO:0007399; P:nervous system development; IMP:MGI.
DR GO; GO:0050772; P:positive regulation of axonogenesis; ISS:UniProtKB.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR GO; GO:1905606; P:regulation of presynapse assembly; ISO:MGI.
DR GO; GO:0050807; P:regulation of synapse organization; ISO:MGI.
DR GO; GO:0007416; P:synapse assembly; ISO:MGI.
DR GO; GO:0099560; P:synaptic membrane adhesion; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; PTHR45773; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 2.
DR PROSITE; PS51450; LRR; 12.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Secreted; Signal; Synapse; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..696
FT /note="SLIT and NTRK-like protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000032674"
FT TOPO_DOM 18..622
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 644..696
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..57
FT /note="LRRNT 1"
FT REPEAT 59..80
FT /note="LRR 1"
FT REPEAT 83..104
FT /note="LRR 2"
FT REPEAT 106..128
FT /note="LRR 3"
FT REPEAT 131..152
FT /note="LRR 4"
FT REPEAT 155..176
FT /note="LRR 5"
FT REPEAT 178..199
FT /note="LRR 6"
FT DOMAIN 212..263
FT /note="LRRCT 1"
FT DOMAIN 332..373
FT /note="LRRNT 2"
FT REPEAT 376..397
FT /note="LRR 7"
FT REPEAT 400..421
FT /note="LRR 8"
FT REPEAT 424..445
FT /note="LRR 9"
FT REPEAT 448..469
FT /note="LRR 10"
FT REPEAT 472..493
FT /note="LRR 11"
FT REPEAT 495..516
FT /note="LRR 12"
FT DOMAIN 529..580
FT /note="LRRCT 2"
FT REGION 268..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 695
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PX8"
SQ SEQUENCE 696 AA; 77817 MW; B3F23AF1A28B9E1B CRC64;
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL QRFTAPTSQF
YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG AFLGLQLVKR LHINNNKIKS
FRKQTFLGLD DLEYLQADFN LLRDIDPGAF QDLNKLEVLI LNDNLISTLP ANVFQYVPIT
HLDLRGNRLK TLPYEEVLEQ IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV
CEAPTRLQGK DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQDEHAT
PGAVPNGGTK IPGNWQLKIK PTPPIATGSA RNKPPVHGLP CPGGCSCDHI PGSGLKMNCN
NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN LILLDLGNNN IANIENNTFK
NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE YLNVEYNAIQ LILPGTFNAM PKLRILILNN
NLLRSLPVDV FAGVSLSKLS LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF
KQWAERLGSE VLMSDLKCET PVNFFRKDFM LLSNEEICPQ LYARISPTLT SHSKNSTGLA
ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK RRDANSSASE
INSLQTVCDS SYWHNGPYNA DGSHRVYDCG SHSLSD
