SLIK2_HUMAN
ID SLIK2_HUMAN Reviewed; 845 AA.
AC Q9H156; A8K117; Q2KHN3; Q5JXB1; Q8NBC7; Q96JH3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=SLIT and NTRK-like protein 2;
DE Flags: Precursor;
GN Name=SLITRK2; Synonyms=CXorf2, KIAA1854, SLITL1; ORFNames=UNQ9197/PRO34756;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000312|EMBL:CAC18888.1};
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAC18888.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Redolfi E., Susani L., Mumm S., Stephan A., Reinbold R.A., Labella T.,
RA Trent J.M., Vezzoni P., Zucchi T.;
RT "The structural characterization of the new gene SLITL1 reveals the
RT presence of an other novel gene embedded within SLITL1 first intron.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain {ECO:0000312|EMBL:BAC03566.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-566.
RC TISSUE=Brain {ECO:0000312|EMBL:BAB47483.1};
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [7] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:14557068}, and
RC Brain tumor {ECO:0000269|PubMed:14557068};
RX PubMed=14557068; DOI=10.1016/s0378-1119(03)00715-7;
RA Aruga J., Yokota N., Mikoshiba K.;
RT "Human SLITRK family genes: genomic organization and expression profiling
RT in normal brain and brain tumor tissue.";
RL Gene 315:87-94(2003).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND CHARACTERIZATION OF VARIANTS MET-89;
RP PHE-549 AND PRO-601.
RX PubMed=27812321; DOI=10.3389/fnmol.2016.00104;
RA Kang H., Han K.A., Won S.Y., Kim H.M., Lee Y.H., Ko J., Um J.W.;
RT "Slitrk missense mutations associated with neuropsychiatric disorders
RT distinctively impair Slitrk trafficking and synapse formation.";
RL Front. Mol. Neurosci. 9:104-104(2016).
RN [9]
RP FUNCTION.
RX PubMed=27273464; DOI=10.1038/srep27343;
RA Beaubien F., Raja R., Kennedy T.E., Fournier A.E., Cloutier J.F.;
RT "Slitrk1 is localized to excitatory synapses and promotes their
RT development.";
RL Sci. Rep. 6:27343-27343(2016).
RN [10]
RP VARIANTS MET-89 AND PHE-549.
RX PubMed=20479760; DOI=10.1038/mp.2010.54;
RA Piton A., Gauthier J., Hamdan F.F., Lafreniere R.G., Yang Y., Henrion E.,
RA Laurent S., Noreau A., Thibodeau P., Karemera L., Spiegelman D., Kuku F.,
RA Duguay J., Destroismaisons L., Jolivet P., Cote M., Lachapelle K.,
RA Diallo O., Raymond A., Marineau C., Champagne N., Xiong L., Gaspar C.,
RA Riviere J.B., Tarabeux J., Cossette P., Krebs M.O., Rapoport J.L.,
RA Addington A., Delisi L.E., Mottron L., Joober R., Fombonne E., Drapeau P.,
RA Rouleau G.A.;
RT "Systematic resequencing of X-chromosome synaptic genes in autism spectrum
RT disorder and schizophrenia.";
RL Mol. Psychiatry 16:867-880(2011).
CC -!- FUNCTION: It is involved in synaptogenesis and promotes excitatory
CC synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses
CC neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q810C0,
CC ECO:0000269|PubMed:27273464, ECO:0000269|PubMed:27812321}.
CC -!- SUBUNIT: Interacts with PTPRD; this interaction is PTPRD splicing-
CC dependent and may induce pre-synaptic differentiation.
CC {ECO:0000250|UniProtKB:Q810C0}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Cell membrane
CC {ECO:0000269|PubMed:27812321}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000305};
CC IsoId=Q9H156-1; Sequence=Displayed;
CC Name=2 {ECO:0000305};
CC IsoId=Q9H156-2; Sequence=VSP_050706, VSP_050707;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex of
CC the brain but also at low levels in the spinal cord and medulla. Also
CC expressed in some astrocytic brain tumors such as astrocytomas,
CC oligodendrogliomas, glioblastomas, gangliogliomas and primitive
CC neuroectodermal tumors. {ECO:0000269|PubMed:14557068}.
CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47483.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y19205; CAC80724.1; -; Genomic_DNA.
DR EMBL; AY358828; AAQ89187.1; -; mRNA.
DR EMBL; AK091015; BAC03566.1; -; mRNA.
DR EMBL; AK289732; BAF82421.1; -; mRNA.
DR EMBL; AL109653; CAI41645.1; -; Genomic_DNA.
DR EMBL; AL109653; CAC18888.1; -; Genomic_DNA.
DR EMBL; BC113011; AAI13012.1; -; mRNA.
DR EMBL; BC113012; AAI13013.1; -; mRNA.
DR EMBL; AB058757; BAB47483.1; ALT_INIT; mRNA.
DR CCDS; CCDS14680.1; -. [Q9H156-1]
DR RefSeq; NP_001137475.1; NM_001144003.2. [Q9H156-1]
DR RefSeq; NP_001137476.1; NM_001144004.2. [Q9H156-1]
DR RefSeq; NP_001137477.1; NM_001144005.2. [Q9H156-1]
DR RefSeq; NP_001137478.1; NM_001144006.2. [Q9H156-1]
DR RefSeq; NP_001137480.1; NM_001144008.2. [Q9H156-1]
DR RefSeq; NP_001137481.1; NM_001144009.2. [Q9H156-1]
DR RefSeq; NP_001137482.1; NM_001144010.2. [Q9H156-1]
DR RefSeq; NP_115928.1; NM_032539.4. [Q9H156-1]
DR RefSeq; XP_005262399.1; XM_005262342.3. [Q9H156-1]
DR RefSeq; XP_005262400.1; XM_005262343.3. [Q9H156-1]
DR RefSeq; XP_005262401.1; XM_005262344.3. [Q9H156-1]
DR RefSeq; XP_005262402.1; XM_005262345.3. [Q9H156-1]
DR AlphaFoldDB; Q9H156; -.
DR SMR; Q9H156; -.
DR BioGRID; 124160; 2.
DR STRING; 9606.ENSP00000359521; -.
DR GlyGen; Q9H156; 4 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9H156; -.
DR PhosphoSitePlus; Q9H156; -.
DR BioMuta; SLITRK2; -.
DR DMDM; 46397026; -.
DR jPOST; Q9H156; -.
DR MassIVE; Q9H156; -.
DR PaxDb; Q9H156; -.
DR PeptideAtlas; Q9H156; -.
DR PRIDE; Q9H156; -.
DR ProteomicsDB; 80355; -. [Q9H156-1]
DR ProteomicsDB; 80356; -. [Q9H156-2]
DR Antibodypedia; 30574; 148 antibodies from 28 providers.
DR DNASU; 84631; -.
DR Ensembl; ENST00000335565.6; ENSP00000334374.5; ENSG00000185985.11. [Q9H156-1]
DR Ensembl; ENST00000370490.1; ENSP00000359521.1; ENSG00000185985.11. [Q9H156-1]
DR GeneID; 84631; -.
DR KEGG; hsa:84631; -.
DR MANE-Select; ENST00000335565.6; ENSP00000334374.5; NM_032539.5; NP_115928.1.
DR UCSC; uc033eyj.2; human. [Q9H156-1]
DR CTD; 84631; -.
DR DisGeNET; 84631; -.
DR GeneCards; SLITRK2; -.
DR HGNC; HGNC:13449; SLITRK2.
DR HPA; ENSG00000185985; Tissue enhanced (brain, retina).
DR MIM; 300561; gene.
DR neXtProt; NX_Q9H156; -.
DR OpenTargets; ENSG00000185985; -.
DR PharmGKB; PA134968225; -.
DR VEuPathDB; HostDB:ENSG00000185985; -.
DR eggNOG; ENOG502QR6C; Eukaryota.
DR GeneTree; ENSGT00940000161248; -.
DR InParanoid; Q9H156; -.
DR OMA; GEQVAYY; -.
DR OrthoDB; 217854at2759; -.
DR PhylomeDB; Q9H156; -.
DR TreeFam; TF351826; -.
DR PathwayCommons; Q9H156; -.
DR Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases.
DR BioGRID-ORCS; 84631; 10 hits in 697 CRISPR screens.
DR ChiTaRS; SLITRK2; human.
DR GeneWiki; SLITRK2; -.
DR GenomeRNAi; 84631; -.
DR Pharos; Q9H156; Tbio.
DR PRO; PR:Q9H156; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9H156; protein.
DR Bgee; ENSG00000185985; Expressed in ventricular zone and 124 other tissues.
DR ExpressionAtlas; Q9H156; baseline and differential.
DR Genevisible; Q9H156; HS.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.
DR GO; GO:1905606; P:regulation of presynapse assembly; IDA:SynGO.
DR GO; GO:0050807; P:regulation of synapse organization; IDA:SynGO.
DR GO; GO:0099560; P:synaptic membrane adhesion; IDA:SynGO.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; PTHR45773; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 2.
DR PROSITE; PS51450; LRR; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..845
FT /note="SLIT and NTRK-like protein 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000032675"
FT TOPO_DOM 22..621
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 643..845
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 63..84
FT /note="LRR 1"
FT REPEAT 87..108
FT /note="LRR 2"
FT REPEAT 111..132
FT /note="LRR 3"
FT REPEAT 135..156
FT /note="LRR 4"
FT REPEAT 159..180
FT /note="LRR 5"
FT REPEAT 182..203
FT /note="LRR 6"
FT DOMAIN 216..265
FT /note="LRRCT 1"
FT DOMAIN 331..373
FT /note="LRRNT"
FT REPEAT 376..397
FT /note="LRR 7"
FT REPEAT 400..421
FT /note="LRR 8"
FT REPEAT 424..445
FT /note="LRR 9"
FT REPEAT 448..469
FT /note="LRR 10"
FT REPEAT 472..493
FT /note="LRR 11"
FT REPEAT 495..516
FT /note="LRR 12"
FT DOMAIN 529..580
FT /note="LRRCT 2"
FT REGION 167..215
FT /note="Required for interaction with PTPRD"
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT REGION 263..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 756
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 421
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..35
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT DISULFID 33..46
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT DISULFID 220..243
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT DISULFID 222..263
FT /evidence="ECO:0000250|UniProtKB:Q810C0"
FT VAR_SEQ 719..733
FT /note="SYSNLEEKKEEPATP -> KTSLENIWRPCLHKK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_050706"
FT VAR_SEQ 734..845
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_050707"
FT VARIANT 89
FT /note="V -> M (found in a patient with schizophrenia;
FT unknown pathological significance; does not impair
FT synaptogenesis; no effect on localization to cell membrane;
FT dbSNP:rs1402893590)"
FT /evidence="ECO:0000269|PubMed:20479760,
FT ECO:0000269|PubMed:27812321"
FT /id="VAR_077630"
FT VARIANT 549
FT /note="S -> F (found in a patient with schizophrenia;
FT unknown pathological significance; does not impair
FT synaptogenesis; no effect on localization to cell membrane;
FT dbSNP:rs1239180055)"
FT /evidence="ECO:0000269|PubMed:20479760,
FT ECO:0000269|PubMed:27812321"
FT /id="VAR_077631"
FT VARIANT 601
FT /note="S -> P (does not affect synaptogenesis; no effect on
FT localization to cell membrane; dbSNP:rs2295336)"
FT /evidence="ECO:0000269|PubMed:27812321"
FT /id="VAR_027756"
FT CONFLICT 721
FT /note="S -> G (in Ref. 3; BAC03566)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 845 AA; 95404 MW; 20E35DBD1584F9A4 CRC64;
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG FTTVSLLQPP
QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE IRTGAFSGLK TLKRLHLNNN
KLEILREDTF LGLESLEYLQ ADYNYISAIE AGAFSKLNKL KVLILNDNLL LSLPSNVFRF
VLLTHLDLRG NRLKVMPFAG VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE
IVCETPFRLH GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK
ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS SDNGLNVNCQ
ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS LDLLHLGNNR IAVIQEGAFT
NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ YLYLEYNVIK EIKPLTFDAL INLQLLFLNN
NLLRSLPDNI FGGTALTRLN LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL
KDWTEHANSP VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR
SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV PSVPRNTNNL
DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI YMQKEGDPVA YYRNLQEFSY
SNLEEKKEEP ATPAYTISAT ELLEKQATPR EPELLYQNIA ERVKELPSAG LVHYNFCTLP
KRQFAPSYES RRQNQDRINK TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT
AISQL
