SLIK3_HUMAN
ID SLIK3_HUMAN Reviewed; 977 AA.
AC O94933; Q1RMY6;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=SLIT and NTRK-like protein 3;
DE Flags: Precursor;
GN Name=SLITRK3; Synonyms=KIAA0848;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain, and Brain tumor;
RX PubMed=14557068; DOI=10.1016/s0378-1119(03)00715-7;
RA Aruga J., Yokota N., Mikoshiba K.;
RT "Human SLITRK family genes: genomic organization and expression profiling
RT in normal brain and brain tumor tissue.";
RL Gene 315:87-94(2003).
CC -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.
CC -!- INTERACTION:
CC O94933; O76024: WFS1; NbExp=3; IntAct=EBI-20855537, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the occipital lobe of the cerebral
CC cortex of the brain. Expressed at higher levels in some astrocytic
CC brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas,
CC gangliogliomas and primitive neuroectodermal tumors.
CC {ECO:0000269|PubMed:14557068}.
CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA74871.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB020655; BAA74871.2; ALT_INIT; mRNA.
DR EMBL; AK290024; BAF82713.1; -; mRNA.
DR EMBL; CH471052; EAW78599.1; -; Genomic_DNA.
DR EMBL; BC114621; AAI14622.1; -; mRNA.
DR CCDS; CCDS3197.1; -.
DR RefSeq; NP_001305739.1; NM_001318810.1.
DR RefSeq; NP_001305740.1; NM_001318811.1.
DR RefSeq; NP_055741.2; NM_014926.3.
DR AlphaFoldDB; O94933; -.
DR SMR; O94933; -.
DR BioGRID; 116533; 20.
DR IntAct; O94933; 5.
DR STRING; 9606.ENSP00000420091; -.
DR GlyGen; O94933; 2 sites.
DR iPTMnet; O94933; -.
DR PhosphoSitePlus; O94933; -.
DR BioMuta; SLITRK3; -.
DR EPD; O94933; -.
DR jPOST; O94933; -.
DR MassIVE; O94933; -.
DR PaxDb; O94933; -.
DR PeptideAtlas; O94933; -.
DR PRIDE; O94933; -.
DR ProteomicsDB; 50569; -.
DR Antibodypedia; 2998; 118 antibodies from 26 providers.
DR DNASU; 22865; -.
DR Ensembl; ENST00000241274.3; ENSP00000241274.3; ENSG00000121871.4.
DR Ensembl; ENST00000475390.2; ENSP00000420091.1; ENSG00000121871.4.
DR GeneID; 22865; -.
DR KEGG; hsa:22865; -.
DR MANE-Select; ENST00000475390.2; ENSP00000420091.1; NM_001318810.2; NP_001305739.1.
DR UCSC; uc003fej.4; human.
DR CTD; 22865; -.
DR DisGeNET; 22865; -.
DR GeneCards; SLITRK3; -.
DR HGNC; HGNC:23501; SLITRK3.
DR HPA; ENSG00000121871; Tissue enhanced (brain, fallopian tube, liver).
DR MalaCards; SLITRK3; -.
DR MIM; 609679; gene.
DR neXtProt; NX_O94933; -.
DR OpenTargets; ENSG00000121871; -.
DR PharmGKB; PA134958002; -.
DR VEuPathDB; HostDB:ENSG00000121871; -.
DR eggNOG; ENOG502QYY5; Eukaryota.
DR GeneTree; ENSGT00940000158681; -.
DR HOGENOM; CLU_012706_0_0_1; -.
DR InParanoid; O94933; -.
DR OMA; NKENAWP; -.
DR OrthoDB; 217854at2759; -.
DR PhylomeDB; O94933; -.
DR TreeFam; TF351826; -.
DR PathwayCommons; O94933; -.
DR Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases.
DR Reactome; R-HSA-9013423; RAC3 GTPase cycle.
DR SignaLink; O94933; -.
DR BioGRID-ORCS; 22865; 8 hits in 1061 CRISPR screens.
DR GenomeRNAi; 22865; -.
DR Pharos; O94933; Tbio.
DR PRO; PR:O94933; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O94933; protein.
DR Bgee; ENSG00000121871; Expressed in left uterine tube and 111 other tissues.
DR ExpressionAtlas; O94933; baseline and differential.
DR Genevisible; O94933; HS.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IDA:SynGO.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0097116; P:gephyrin clustering involved in postsynaptic density assembly; IEA:Ensembl.
DR GO; GO:0072578; P:neurotransmitter-gated ion channel clustering; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IBA:GO_Central.
DR GO; GO:1905606; P:regulation of presynapse assembly; IDA:SynGO.
DR GO; GO:0099560; P:synaptic membrane adhesion; IDA:SynGO.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0072553; P:terminal button organization; IEA:Ensembl.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; PTHR45773; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 2.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..977
FT /note="SLIT and NTRK-like protein 3"
FT /id="PRO_0000032677"
FT TOPO_DOM 29..654
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 676..977
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 78..99
FT /note="LRR 1"
FT REPEAT 102..123
FT /note="LRR 2"
FT REPEAT 126..147
FT /note="LRR 3"
FT REPEAT 150..171
FT /note="LRR 4"
FT REPEAT 174..195
FT /note="LRR 5"
FT REPEAT 197..218
FT /note="LRR 6"
FT DOMAIN 232..283
FT /note="LRRCT 1"
FT DOMAIN 364..406
FT /note="LRRNT"
FT REPEAT 409..430
FT /note="LRR 7"
FT REPEAT 433..454
FT /note="LRR 8"
FT REPEAT 457..478
FT /note="LRR 9"
FT REPEAT 481..502
FT /note="LRR 10"
FT REPEAT 505..526
FT /note="LRR 11"
FT REPEAT 528..549
FT /note="LRR 12"
FT DOMAIN 562..613
FT /note="LRRCT 2"
FT REGION 325..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 596
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 605
FT /note="I -> V (in dbSNP:rs3828419)"
FT /id="VAR_027757"
FT CONFLICT 940
FT /note="G -> E (in Ref. 1; BAA74871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 977 AA; 108934 MW; 66936B7E00008961 CRC64;
MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC EVKESLFHIH
CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL NNAVSINLGN NALQDIQTGA
FNGLKILKRL YLHENKLDVF RNDTFLGLES LEYLQADYNV IKRIESGAFR NLSKLRVLIL
NDNLIPMLPT NLFKAVSLTH LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI
VQLKSWLERI PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS
SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA LYPGPNQPPI
APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI SELLPRPLNA KKLYLSSNLI
QKIYRSDFWN FSSLDLLHLG NNRISYVQDG AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ
SLHYLYFEFN VIREIQPAAF SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL
YLPVAGVLEH LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR
DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP VPLSVLILSL
LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG IQMQCHRLFE DGGGGGGGSG
GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP
GTQPPGMGEA LLGSEQFAET PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH
PAVGGVSGVV GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV
DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK SDYLELRAKL
QTKPDYLEVL EKTTYRF
