SLIK3_MOUSE
ID SLIK3_MOUSE Reviewed; 980 AA.
AC Q810B9; Q6NZM5;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=SLIT and NTRK-like protein 3;
DE Flags: Precursor;
GN Name=Slitrk3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:BAC67206.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14550773; DOI=10.1016/s1044-7431(03)00129-5;
RA Aruga J., Mikoshiba K.;
RT "Identification and characterization of Slitrk, a novel neuronal
RT transmembrane protein family controlling neurite outgrowth.";
RL Mol. Cell. Neurosci. 24:117-129(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000269|PubMed:14550773}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Broadly expressed in embryonic brain with highest
CC expression in cortical plate, pyramidal cell layer of the hippocampus,
CC thalamus and hypothalamus. {ECO:0000269|PubMed:14550773}.
CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
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DR EMBL; AB097572; BAC67206.1; -; Genomic_DNA.
DR EMBL; AK158856; BAE34696.1; -; mRNA.
DR EMBL; CH466547; EDL15486.1; -; Genomic_DNA.
DR EMBL; BC066059; AAH66059.1; -; mRNA.
DR CCDS; CCDS17410.1; -.
DR RefSeq; NP_942564.2; NM_198864.2.
DR RefSeq; XP_006501701.1; XM_006501638.1.
DR RefSeq; XP_006501702.1; XM_006501639.2.
DR RefSeq; XP_006501703.1; XM_006501640.2.
DR RefSeq; XP_006501704.1; XM_006501641.2.
DR RefSeq; XP_006501705.1; XM_006501642.2.
DR AlphaFoldDB; Q810B9; -.
DR SMR; Q810B9; -.
DR STRING; 10090.ENSMUSP00000088561; -.
DR GlyGen; Q810B9; 2 sites.
DR iPTMnet; Q810B9; -.
DR PhosphoSitePlus; Q810B9; -.
DR MaxQB; Q810B9; -.
DR PaxDb; Q810B9; -.
DR PRIDE; Q810B9; -.
DR ProteomicsDB; 258691; -.
DR Antibodypedia; 2998; 118 antibodies from 26 providers.
DR DNASU; 386750; -.
DR Ensembl; ENSMUST00000059407; ENSMUSP00000088561; ENSMUSG00000048304.
DR Ensembl; ENSMUST00000192477; ENSMUSP00000141236; ENSMUSG00000048304.
DR GeneID; 386750; -.
DR KEGG; mmu:386750; -.
DR UCSC; uc008pms.1; mouse.
DR CTD; 22865; -.
DR MGI; MGI:2679447; Slitrk3.
DR VEuPathDB; HostDB:ENSMUSG00000048304; -.
DR eggNOG; ENOG502QYY5; Eukaryota.
DR GeneTree; ENSGT00940000158681; -.
DR HOGENOM; CLU_012706_0_0_1; -.
DR InParanoid; Q810B9; -.
DR OMA; NKENAWP; -.
DR OrthoDB; 217854at2759; -.
DR PhylomeDB; Q810B9; -.
DR TreeFam; TF351826; -.
DR Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases.
DR Reactome; R-MMU-9013423; RAC3 GTPase cycle.
DR BioGRID-ORCS; 386750; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Slitrk3; mouse.
DR PRO; PR:Q810B9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q810B9; protein.
DR Bgee; ENSMUSG00000048304; Expressed in rostral migratory stream and 60 other tissues.
DR Genevisible; Q810B9; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:MGI.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; ISO:MGI.
DR GO; GO:0007409; P:axonogenesis; IDA:MGI.
DR GO; GO:0097116; P:gephyrin clustering involved in postsynaptic density assembly; IMP:MGI.
DR GO; GO:0072578; P:neurotransmitter-gated ion channel clustering; IDA:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR GO; GO:0097107; P:postsynaptic density assembly; IMP:MGI.
DR GO; GO:1905606; P:regulation of presynapse assembly; IDA:SynGO.
DR GO; GO:0099560; P:synaptic membrane adhesion; ISO:MGI.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IDA:MGI.
DR GO; GO:0072553; P:terminal button organization; IMP:MGI.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; PTHR45773; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 2.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..980
FT /note="SLIT and NTRK-like protein 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000032678"
FT TOPO_DOM 30..655
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..676
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 677..980
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 79..100
FT /note="LRR 1"
FT REPEAT 103..124
FT /note="LRR 2"
FT REPEAT 127..148
FT /note="LRR 3"
FT REPEAT 151..172
FT /note="LRR 4"
FT REPEAT 175..196
FT /note="LRR 5"
FT REPEAT 198..219
FT /note="LRR 6"
FT DOMAIN 233..284
FT /note="LRRCT 1"
FT DOMAIN 365..407
FT /note="LRRNT"
FT REPEAT 410..431
FT /note="LRR 7"
FT REPEAT 434..455
FT /note="LRR 8"
FT REPEAT 458..479
FT /note="LRR 9"
FT REPEAT 482..503
FT /note="LRR 10"
FT REPEAT 506..527
FT /note="LRR 11"
FT REPEAT 529..550
FT /note="LRR 12"
FT DOMAIN 563..614
FT /note="LRRCT 2"
FT REGION 326..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..361
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 597
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 636
FT /note="G -> R (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
FT CONFLICT 690
FT /note="R -> K (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
FT CONFLICT 721..723
FT /note="GGG -> EGE (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
FT CONFLICT 732
FT /note="E -> K (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
FT CONFLICT 735
FT /note="P -> L (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
FT CONFLICT 977
FT /note="A -> T (in Ref. 1; BAC67206)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 980 AA; 109406 MW; C7671B133C601314 CRC64;
MMKPSIAEML HRGRMLWIIL LSTIALGWTT PIPLIEDSEE IDEPCFDPCY CEVKESLFHI
HCDSKGFTNI SQITEFWSRP FKLYLQRNSM RRLYTNSFLH LNNAVSINLG NNALQDIQTG
AFNGLKILKR LYLHENKLDV FRNDTFLGLE SLEYLQADYN VIKRIESGAF RNLSKLRVLI
LNDNLIPVLP TNLFKAVSLT HLDLRGNRLK VLFYRGMLDH IGRSLMELQL EENPWNCTCE
IVQLKSWLER IPYTALVGDI TCETPFHFHG KDLREIKKTE LCPLLSDSEV EASLGIPHLS
SSKENAWPTK PSSMLSSVHF TASSVEYKSS NKQPKPTKQP RTPRPPSTSQ ALYPGPNQPP
IAPYQTRPPI PIICPTGCTC NLHINDLGLT VNCKERGFNN ISELLPRPLN AKKLYLSSNL
IQKIYRSDFW NFSSLDLLHL GNNRISYVQD GAFINLPNLK SLFLNGNDIE KLTPGMFRGL
QSLHYLYFEF NVIREIQPAA FSLMPNLKLL FLNNNLLRTL PTDAFAGTSL ARLNLRKNYF
LYLPVAGVLE HLNAIVQIDL NENPWDCTCD LVPFKQWIET ISSVSVVGDV LCRTPENLTH
RDVRTIELEV LCPEMLHIAQ PGPSPPQPGD YHPNGGPTSA SPYEFSPPGG PVPLSVLILS
LLVLFFSAVF VAAGLFAYVL RRRRKKLPFR SKRQEGVDLT GIQMQCHRLF EDSGGNSGGS
GGGGRPTLSS PEKAPPVGHV YEYIPHPVTQ MCNNPIYKPR EEEEVAASAA QDTGATDRGG
PGTQPTGMAE VLLGSEQFAE TPKENHSNYR TLLEKEKEWA LAVSNSQLNT IVTVNHHHPH
PHHSAVGGVS GVGGGTGGDL AGFRHHEKNG GVVLFPPGGG CGGGSLLLDR ERPQPAPCTV
GFVDCLYGTV PKLKELHVHP PGMQYPDLQQ DARLKETLLF SAGKGFTDHQ TPKSDYLDLR
AKLQTKPDYL EVLEKTAYRF
