SLIK5_MOUSE
ID SLIK5_MOUSE Reviewed; 957 AA.
AC Q810B7; Q9CT21;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=SLIT and NTRK-like protein 5;
DE Flags: Precursor;
GN Name=Slitrk5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:BAC67208.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=14550773; DOI=10.1016/s1044-7431(03)00129-5;
RA Aruga J., Mikoshiba K.;
RT "Identification and characterization of Slitrk, a novel neuronal
RT transmembrane protein family controlling neurite outgrowth.";
RL Mol. Cell. Neurosci. 24:117-129(2003).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH65107.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH65107.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 830-957 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000269|PubMed:14550773}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:14550773};
CC IsoId=Q810B7-1; Sequence=Displayed;
CC Name=2 {ECO:0000305};
CC IsoId=Q810B7-2; Sequence=VSP_050708, VSP_050709, VSP_050710;
CC -!- TISSUE SPECIFICITY: In the adult, significant expression is detected
CC only in the brain. In the embryo, expressed in the subventricular zone,
CC cortical plate, pyramidal layer of hippocampus, thalamus and
CC hypothalamus. {ECO:0000269|PubMed:14550773}.
CC -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK011457; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB097574; BAC67208.1; -; Genomic_DNA.
DR EMBL; BC065107; AAH65107.1; -; mRNA.
DR EMBL; AK011457; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS27328.1; -. [Q810B7-1]
DR RefSeq; NP_942565.1; NM_198865.1. [Q810B7-1]
DR RefSeq; XP_006519705.1; XM_006519642.3.
DR RefSeq; XP_006519706.1; XM_006519643.3.
DR AlphaFoldDB; Q810B7; -.
DR SMR; Q810B7; -.
DR BioGRID; 217460; 2.
DR STRING; 10090.ENSMUSP00000041499; -.
DR GlyGen; Q810B7; 2 sites.
DR iPTMnet; Q810B7; -.
DR PhosphoSitePlus; Q810B7; -.
DR MaxQB; Q810B7; -.
DR PaxDb; Q810B7; -.
DR PRIDE; Q810B7; -.
DR ProteomicsDB; 258693; -. [Q810B7-1]
DR ProteomicsDB; 258694; -. [Q810B7-2]
DR Antibodypedia; 2571; 141 antibodies from 29 providers.
DR DNASU; 75409; -.
DR Ensembl; ENSMUST00000042767; ENSMUSP00000041499; ENSMUSG00000033214. [Q810B7-1]
DR GeneID; 75409; -.
DR KEGG; mmu:75409; -.
DR UCSC; uc011zpr.1; mouse. [Q810B7-1]
DR CTD; 26050; -.
DR MGI; MGI:2679448; Slitrk5.
DR VEuPathDB; HostDB:ENSMUSG00000033214; -.
DR eggNOG; ENOG502QUVV; Eukaryota.
DR GeneTree; ENSGT00940000158453; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; Q810B7; -.
DR OMA; IGLNVNC; -.
DR OrthoDB; 217854at2759; -.
DR PhylomeDB; Q810B7; -.
DR TreeFam; TF326378; -.
DR Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases.
DR Reactome; R-MMU-9013404; RAC2 GTPase cycle.
DR Reactome; R-MMU-9013423; RAC3 GTPase cycle.
DR BioGRID-ORCS; 75409; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Slitrk5; mouse.
DR PRO; PR:Q810B7; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q810B7; protein.
DR Bgee; ENSMUSG00000033214; Expressed in subiculum and 107 other tissues.
DR ExpressionAtlas; Q810B7; baseline and differential.
DR Genevisible; Q810B7; MM.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0030534; P:adult behavior; IMP:MGI.
DR GO; GO:0007409; P:axonogenesis; IDA:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IMP:MGI.
DR GO; GO:0072359; P:circulatory system development; IMP:MGI.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:MGI.
DR GO; GO:0007625; P:grooming behavior; IMP:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IMP:MGI.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR GO; GO:0021756; P:striatum development; IMP:MGI.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; PTHR45773; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..957
FT /note="SLIT and NTRK-like protein 5"
FT /evidence="ECO:0000255"
FT /id="PRO_0000032682"
FT TOPO_DOM 41..664
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 686..957
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 82..103
FT /note="LRR 1"
FT REPEAT 106..127
FT /note="LRR 2"
FT REPEAT 130..151
FT /note="LRR 3"
FT REPEAT 154..175
FT /note="LRR 4"
FT REPEAT 178..199
FT /note="LRR 5"
FT REPEAT 201..222
FT /note="LRR 6"
FT DOMAIN 235..286
FT /note="LRRCT 1"
FT DOMAIN 365..407
FT /note="LRRNT"
FT REPEAT 410..431
FT /note="LRR 7"
FT REPEAT 434..455
FT /note="LRR 8"
FT REPEAT 458..479
FT /note="LRR 9"
FT REPEAT 482..503
FT /note="LRR 10"
FT REPEAT 506..527
FT /note="LRR 11"
FT REPEAT 529..550
FT /note="LRR 12"
FT DOMAIN 563..614
FT /note="LRRCT 2"
FT REGION 317..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..811
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 644
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 706..722
FT /note="DVSSFNMQYSVYGGGGG -> AATAPAAAPSADADAAW (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_050708"
FT VAR_SEQ 726..755
FT /note="GHPHAHVHHRGPALPKVKTPAGHVYEYIPH -> EAGKPPFEEPRLQRQHHR
FT APRGPTVAGAGR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_050709"
FT VAR_SEQ 756..957
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_050710"
FT CONFLICT 153
FT /note="E -> D (in Ref. 2; AAH65107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 957 AA; 107165 MW; 0CB89BD7FE2D18AF CRC64;
MHVCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI
LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLSRLYPNE FVNYTGASIL HLGSNVIQDI
ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHMLQ
VLILNDNLLS GLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS
CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRKLIS DYEMRPQTPL
STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP
SIAYQTKSPV PLECPTACTC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY
ITVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLGNLR RLYLNGNRIE RLSPELFYGL
QSLQYLFLQY NLIREIQAGT FDPVPNLQLL FLNNNQLQAM PSGVFSGLTL LRLNLRGNSF
TSLPVSGVLD QLTSLIQIDL HDNPWDCTCD VVGMKLWIEQ LKVGVLVDEV ICKAPKKFAE
TYMRSIKSEL LCPDYSDVVV STPTPSSIQV PSRTNAATPA VRLNSTGTPA GLGAGTGASS
VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG
GGGGGGHPHA HVHHRGPALP KVKTPAGHVY EYIPHPLGHM CKNPIYRSRE GNSVEDYKDL
HELKVTYSSN HHLQQQPPPP PQQPQQQPPP QMQMQPGEEE RRESHHLRSP AYSVSTIEPR
EDLLSPVQDA DRFYRGILEP DKHCSTTPAG SSLPEYPKFP CSPAAYTFSP NYDLRRPHQY
LHPGAGESRL REPVLYSPPG AVFVEPNRNE YLELKAKLNV EPDYLEVLEK QTTFSQF
