SLIP1_DROME
ID SLIP1_DROME Reviewed; 767 AA.
AC Q8MR31; Q8STH5; Q9V4F2;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Slo-interacting protein 1;
DE AltName: Full=dSLIP1;
GN Name=Slip1; ORFNames=CG1783;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, AND
RP INTERACTION WITH SLO.
RC TISSUE=Head;
RX PubMed=9502797; DOI=10.1523/jneurosci.18-07-02360.1998;
RA Xia X.-M., Hirschberg B., Smolik S., Forte M., Adelman J.P.;
RT "dSLo interacting protein 1, a novel protein that interacts with large-
RT conductance calcium-activated potassium channels.";
RL J. Neurosci. 18:2360-2369(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 252-282.
RC STRAIN=253.27, and 253.30;
RX PubMed=11778050; DOI=10.1126/science.1064521;
RA Wang W., Thornton K., Berry A., Long M.;
RT "Nucleotide variation along the Drosophila melanogaster fourth
RT chromosome.";
RL Science 295:134-137(2002).
CC -!- FUNCTION: May selectively reduce calcium-activated potassium channel
CC (Slo) currents by reducing the number of Slo channels in the plasma
CC membrane. {ECO:0000269|PubMed:9502797}.
CC -!- SUBUNIT: Interacts with Slo. {ECO:0000269|PubMed:9502797}.
CC -!- INTERACTION:
CC Q8MR31; Q03720: slo; NbExp=5; IntAct=EBI-123875, EBI-426805;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8MR31-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8MR31-2; Sequence=VSP_010098;
CC -!- TISSUE SPECIFICITY: In embryos, it is expressed throughout the CNS and
CC in several peripheral locations. Colocalizes with Slo.
CC {ECO:0000269|PubMed:9502797}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014135; AAF59321.1; -; Genomic_DNA.
DR EMBL; AY122157; AAM52669.1; ALT_INIT; mRNA.
DR EMBL; AF433691; AAM17954.1; -; Genomic_DNA.
DR EMBL; AF433692; AAM17955.1; -; Genomic_DNA.
DR RefSeq; NP_651933.1; NM_143676.2. [Q8MR31-1]
DR AlphaFoldDB; Q8MR31; -.
DR SMR; Q8MR31; -.
DR BioGRID; 68640; 7.
DR DIP; DIP-18620N; -.
DR IntAct; Q8MR31; 1.
DR STRING; 7227.FBpp0088159; -.
DR PaxDb; Q8MR31; -.
DR DNASU; 43809; -.
DR EnsemblMetazoa; FBtr0089090; FBpp0088159; FBgn0024728. [Q8MR31-1]
DR GeneID; 43809; -.
DR KEGG; dme:Dmel_CG1783; -.
DR UCSC; CG1783-RA; d. melanogaster. [Q8MR31-1]
DR CTD; 43809; -.
DR FlyBase; FBgn0024728; Slip1.
DR VEuPathDB; VectorBase:FBgn0024728; -.
DR eggNOG; KOG0312; Eukaryota.
DR GeneTree; ENSGT00950000183062; -.
DR HOGENOM; CLU_027236_0_0_1; -.
DR InParanoid; Q8MR31; -.
DR OMA; TMEQDYY; -.
DR PhylomeDB; Q8MR31; -.
DR SignaLink; Q8MR31; -.
DR BioGRID-ORCS; 43809; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 43809; -.
DR PRO; PR:Q8MR31; -.
DR Proteomes; UP000000803; Chromosome 4.
DR Bgee; FBgn0024728; Expressed in wing disc and 25 other tissues.
DR ExpressionAtlas; Q8MR31; baseline and differential.
DR Genevisible; Q8MR31; DM.
DR GO; GO:0015459; F:potassium channel regulator activity; IDA:UniProtKB.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..767
FT /note="Slo-interacting protein 1"
FT /id="PRO_0000071957"
FT DOMAIN 202..280
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 521..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 215..520
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_010098"
SQ SEQUENCE 767 AA; 85846 MW; 8914206A7C34E46F CRC64;
MSIADVEYEY VVLKINGYDI SHLSRYEAVQ KFLQSKETLV VEIRRQKHNA LDLELKHGSN
AKISKVDNPG ELSVLTDKSA EGTITAASAS QQINCPSSTS LKEIETKTPV VLTLRARSHE
DRLGSLQAAS KETQTQSVVG TDVLKDNDLV NTITDNFIEH EHHLFEQCLE PEIDIEEVTL
VKGVEQSSSN QIGLIVTSSG IQQSSTDTNK GDILGNVLEH SEDVFISGVQ PESIAYRDGR
LRQGDQILRI NGLDVKNQEE LETQIARSST SVTLLVSRIL YPEDDDDEDI HFEYANTFLP
DDYTNVVDKL DKVLLTHVKS LEELSNKSAM QSDECYHIPE KNSSDSNVKI SSLAKNIIEQ
STKSCSKIKL RPNANLDYKK KFNLPLSQEE VHLQYEYDES EHIYETIPED SESEPVYCSP
YQRSNDKTSI GCSSPIASRP AESLERTMQQ QTQRVAQWLG LKPQYQKTRQ TLVGRPPPLK
LVQQPTCSRV FTLRSTLTNT SASSSSGVAY SSYGQNNVVT GNAAAPGEEV DNSSSAYNTG
DSNNSASPHQ NTTNPDEAIA TGRKLDSTVI DSPNDHLDAT GVSTMLLLPF GKSGRIGLCS
SNLPTAYVSE RYTNVGSENE IHPLKSDIEI LRVKPTDDSY SHCPQFNAPN LSSYHFVSSQ
EVANRCHIST SLQKNATLLN GESAEEIPMV WKVKRRPDGT RYIVKRPVRN RPQVALRKNM
RYNEVTTTED DTISEVKIGR YWTKEERKRH IERAREKRHH QTQQQQQ
