ID   SLIRP_BOVIN             Reviewed;         111 AA.
AC   Q32P59;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=SRA stem-loop-interacting RNA-binding protein, mitochondrial;
DE   Flags: Precursor;
GN   Name=SLIRP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that acts as a nuclear receptor
CC       corepressor. Probably acts by binding the SRA RNA, and repressing the
CC       SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA
CC       RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid
CC       (TR) and VDR-mediated transactivation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Predominantly mitochondrial. Some fraction is
CC       nuclear. In the nucleus, it is recruited to nuclear receptor target
CC       promoters (By similarity). {ECO:0000250}.
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DR   EMBL; BC108247; AAI08248.1; -; mRNA.
DR   RefSeq; NP_001032562.1; NM_001037485.2.
DR   AlphaFoldDB; Q32P59; -.
DR   SMR; Q32P59; -.
DR   STRING; 9913.ENSBTAP00000040631; -.
DR   PaxDb; Q32P59; -.
DR   PRIDE; Q32P59; -.
DR   GeneID; 613614; -.
DR   KEGG; bta:613614; -.
DR   CTD; 81892; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_012062_28_10_1; -.
DR   InParanoid; Q32P59; -.
DR   OrthoDB; 1587548at2759; -.
DR   TreeFam; TF319527; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12242; RRM_SLIRP; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034152; SLIRP_RRM.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW   RNA-binding; Transcription; Transcription regulation; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..111
FT                   /note="SRA stem-loop-interacting RNA-binding protein,
FT                   mitochondrial"
FT                   /id="PRO_0000247050"
FT   DOMAIN          19..96
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          92..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         104
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D8T7"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D8T7"
SQ   SEQUENCE   111 AA;  12493 MW;  BE9058FD26FFFB72 CRC64;
     MAASAARGAM ALRTNIGRPV AFVRKIPWTA ASSELREHFA QFGHVRKCTV PFDKETGFHK
     GMGWIHFSSE EELHNALQQE NHVIDGVKLH VQPQRPKALQ GDQTSDEEKD F