ID   SLIRP_PONAB             Reviewed;         109 AA.
AC   Q5R8K3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=SRA stem-loop-interacting RNA-binding protein, mitochondrial;
DE   Flags: Precursor;
GN   Name=SLIRP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that acts as a nuclear receptor
CC       corepressor. Probably acts by binding the SRA RNA, and repressing the
CC       SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA
CC       RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid
CC       (TR) and VDR-mediated transactivation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Predominantly mitochondrial. Some fraction is
CC       nuclear. In the nucleus, it is recruited to nuclear receptor target
CC       promoters (By similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859749; CAH91907.1; -; mRNA.
DR   RefSeq; NP_001126105.1; NM_001132633.1.
DR   AlphaFoldDB; Q5R8K3; -.
DR   SMR; Q5R8K3; -.
DR   GeneID; 100173060; -.
DR   CTD; 100173060; -.
DR   InParanoid; Q5R8K3; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd12242; RRM_SLIRP; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034152; SLIRP_RRM.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW   RNA-binding; Transcription; Transcription regulation; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..109
FT                   /note="SRA stem-loop-interacting RNA-binding protein,
FT                   mitochondrial"
FT                   /id="PRO_0000247053"
FT   DOMAIN          19..103
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   MOD_RES         15
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZT3"
FT   MOD_RES         101
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZT3"
FT   MOD_RES         102
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZT3"
SQ   SEQUENCE   109 AA;  12277 MW;  A1F6B6EA244F14EE CRC64;
     MAASAARGAA ALRRSINQPV AFVRRIPWTA ASSQLKEHFA QFGHVRRCIL PFDKETGFHR
     GLGWVQFSSE GGLRNALQQE NHIIDGVKVQ VHTRRPKLPQ TSDDEKKDF