SLK3_ARATH
ID SLK3_ARATH Reviewed; 685 AA.
AC F4JT98;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Probable transcriptional regulator SLK3;
DE Short=AtSLK3;
DE AltName: Full=Protein SEUSS-like 3;
GN Name=SLK3; OrderedLocusNames=At4g25515; ORFNames=M7J2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20007451; DOI=10.1104/pp.109.146183;
RA Bao F., Azhakanandam S., Franks R.G.;
RT "SEUSS and SEUSS-LIKE transcriptional adaptors regulate floral and
RT embryonic development in Arabidopsis.";
RL Plant Physiol. 152:821-836(2010).
CC -!- FUNCTION: Probable transcription regulator that functions in the
CC development of the carpel margin meristem similarly to SEUSS (SEU). In
CC association with SEU, supports organ development from meristematic
CC regions by facilitating auxin response and thus organ initiation, and
CC by sustaining meristematic potential through the maintenance of
CC PHABULOSA expression (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:20007451}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:20007451}.
CC -!- SIMILARITY: Belongs to the adn1/SEU family. {ECO:0000305}.
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DR EMBL; AL022197; CAA18172.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85072.1; -; Genomic_DNA.
DR RefSeq; NP_680741.5; NM_148375.6.
DR AlphaFoldDB; F4JT98; -.
DR STRING; 3702.AT4G25515.1; -.
DR PaxDb; F4JT98; -.
DR PRIDE; F4JT98; -.
DR ProteomicsDB; 234572; -.
DR EnsemblPlants; AT4G25515.1; AT4G25515.1; AT4G25515.
DR GeneID; 828656; -.
DR Gramene; AT4G25515.1; AT4G25515.1; AT4G25515.
DR KEGG; ath:AT4G25515; -.
DR Araport; AT4G25515; -.
DR TAIR; locus:504955415; AT4G25515.
DR eggNOG; ENOG502SZ3H; Eukaryota.
DR HOGENOM; CLU_007007_1_0_1; -.
DR InParanoid; F4JT98; -.
DR OMA; QNFAKGG; -.
DR OrthoDB; 933055at2759; -.
DR PhylomeDB; F4JT98; -.
DR PRO; PR:F4JT98; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JT98; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR Pfam; PF01803; LIM_bind; 1.
PE 3: Inferred from homology;
KW Developmental protein; Differentiation; Flowering; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..685
FT /note="Probable transcriptional regulator SLK3"
FT /id="PRO_0000430165"
FT REGION 25..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..423
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 447..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 185..199
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 36..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 77011 MW; 70051FFEFEEF1E27 CRC64;
MQRSSGINNL HIPTSPMSFS SNGINLPGSM VLDGSPSMQH LPQQQQRQLL EQQAGQGSVP
MRENSYSHVD KKLRLEVKQE DLLQQQILQQ LIQRQDPTGR NPQMQALLQQ QRVRQHQQML
QSMSPSQRLQ LQKQQQLRQQ LQQQGTQQIS PNVRPYEVGV CARKLMMYLY HLQQRPAENC
ITYWRKFVAE YFSPRAKQRL CLSQYESVGH HALGMFPQAA PDMWQCDLCG TKSGKGFEAT
FDVLARLIEI KFASGIIDEL LYLDHPRENR FPNGLMMLEY RKAVQETVHE QFRVVREGHL
RIIFSPDLKI LSWEFCARRH EELLLRRLIA PQVNQLLQVA QKCQSTISES GSQGVSQQDI
QSNSNMVLGA GRQLAKFMEL QSLNDLGYPK RYIRTLQISE VVKSMKDLMN FTGEHKVGPL
EGLKQLLEQT ATVKLQRQKM QEMEQFGNSG AMSGPAQAQM TLSSGTMSGS TANNNSNNHH
QIVGRGAMNG SPQATAALTN YQSMLIRQNA MNNQNSNTGN QEGFSSQNPT LNSNQSPSSS
SQQRENLATS GFPSSPQMQQ QQHILNGTPN MLPQNHPHQL QSPHSHGNTQ EQQMLHQLLQ
EMTENGASVE QQQAFPGQSG SNNNTERNTT ASTSNISGGG RVPSRINSFK ASSNNNLPFS
EDISVTDHDF SEDGFFNNSD IYGGL
