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SLM9_SCHPO
ID   SLM9_SCHPO              Reviewed;         807 AA.
AC   O74309;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Histone transcription regulator slm9;
GN   Name=slm9; ORFNames=SPBC15D4.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10835386; DOI=10.1093/genetics/155.2.623;
RA   Kanoh J., Russell P.;
RT   "Slm9, a novel nuclear protein involved in mitotic control in fission
RT   yeast.";
RL   Genetics 155:623-631(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HIP1.
RX   PubMed=15121850; DOI=10.1128/mcb.24.10.4309-4320.2004;
RA   Blackwell C., Martin K.A., Greenall A., Pidoux A., Allshire R.C.,
RA   Whitehall S.K.;
RT   "The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the
RT   periodic expression of histone genes and contributes to the function of
RT   complex centromeres.";
RL   Mol. Cell. Biol. 24:4309-4320(2004).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH HIP3.
RX   PubMed=16428807; DOI=10.1074/jbc.m512170200;
RA   Greenall A., Williams E.S., Martin K.A., Palmer J.M., Gray J., Liu C.,
RA   Whitehall S.K.;
RT   "Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for
RT   transcriptional silencing and accurate chromosome segregation.";
RL   J. Biol. Chem. 281:8732-8739(2006).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406; SER-421 AND SER-422, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Probably required for replication-independent chromatin
CC       assembly (By similarity). Required for transcriptional silencing in the
CC       outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat
CC       retrotransposons. May play an indirect role in the regulation of cdc2
CC       and/or wee1 at the G2/M stage of mitosis. {ECO:0000250,
CC       ECO:0000269|PubMed:10835386, ECO:0000269|PubMed:15121850,
CC       ECO:0000269|PubMed:16428807}.
CC   -!- SUBUNIT: Interacts with hip1 and hip3. {ECO:0000269|PubMed:15121850,
CC       ECO:0000269|PubMed:16428807}.
CC   -!- INTERACTION:
CC       O74309; P87314: hip1; NbExp=4; IntAct=EBI-1556117, EBI-1556094;
CC       O74309; P87315: hip3; NbExp=3; IntAct=EBI-1556117, EBI-1556159;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA20478.1; -; Genomic_DNA.
DR   PIR; T39479; T39479.
DR   RefSeq; NP_596243.1; NM_001022162.2.
DR   AlphaFoldDB; O74309; -.
DR   SMR; O74309; -.
DR   BioGRID; 276665; 76.
DR   IntAct; O74309; 2.
DR   STRING; 4896.SPBC15D4.03.1; -.
DR   iPTMnet; O74309; -.
DR   MaxQB; O74309; -.
DR   PaxDb; O74309; -.
DR   PRIDE; O74309; -.
DR   EnsemblFungi; SPBC15D4.03.1; SPBC15D4.03.1:pep; SPBC15D4.03.
DR   GeneID; 2540128; -.
DR   KEGG; spo:SPBC15D4.03; -.
DR   PomBase; SPBC15D4.03; slm9.
DR   VEuPathDB; FungiDB:SPBC15D4.03; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_350606_0_0_1; -.
DR   InParanoid; O74309; -.
DR   OMA; SEGWWMI; -.
DR   PhylomeDB; O74309; -.
DR   PRO; PR:O74309; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000785; C:chromatin; IC:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000417; C:HIR complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 2.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..807
FT                   /note="Histone transcription regulator slm9"
FT                   /id="PRO_0000051219"
FT   REPEAT          62..100
FT                   /note="WD 1"
FT   REPEAT          102..140
FT                   /note="WD 2"
FT   REPEAT          182..221
FT                   /note="WD 3"
FT   REPEAT          230..273
FT                   /note="WD 4"
FT   REPEAT          276..322
FT                   /note="WD 5"
FT   REPEAT          326..367
FT                   /note="WD 6"
FT   REPEAT          492..526
FT                   /note="WD 7"
FT   REPEAT          528..574
FT                   /note="WD 8"
FT   REGION          144..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         406
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         421
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         422
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   807 AA;  90433 MW;  B8BFB73852EB7B45 CRC64;
     MHIFVPKLLE NHQFSSISSS KDFVAVSAET NVYILSKDFF YPKSSEKRII QSLNGHKTTH
     LSFDSPISCI RFTYDGSCLA VATEAGTFLY HSEKWDKAFQ VLSGPAYEVC WSQQGHILAT
     SWKQISIYVK DEGLRTETIV KKTEHADSNH QPAVSIEESK EAVESTSQSS EISFKLIKVI
     EGHHTFVGGL AFDPMGQFLA SQSFDHTLKV WKLSTFGVEK SIAKPFEQMP TGNRFLRLSW
     SPDGAHIASV NAVNEGAYVI AIVQRDTWTY DINLVGHQGP LECATFNPYL YEDPFQKSII
     ASAAHDGCVS IWNTACARPM AVIHELSCSS FVDLQWSTSG FELYGVSLDG NLMLLQFEES
     EFGEKMDTIH YPDDLSYFNS SRSKAHVNKN AAADRTTSPT QGQPESPSKS ILLRPPPSIA
     SSPESKRRKC PKKFVARPPV PHPTSLYSQI RIGCPYLKPK LVISKSFGTL IVKNHNQLSL
     LKCTFSNLDG NDCSWFSYLP NAIVLANGTS VFWAVATEDS SIYIYSPAGR LLLPPVVVAA
     TPCFLECCGD FLCCIVSTGL LYIWNIKNFE AIHSPVSTLP LFHSNFSVSK IARGPSIEQF
     FVTKQGHPVA IMSDGNAFAF IRDSSSWLRV SEGWWMIGSQ YWGPLASESN EESPLGFLER
     CTDEEIIKAG RGRFLQRLVK ALMLRQGYDN YEMLVSIRHL ENRLMSSAKL DLEYDFRENL
     ILYAKKIAEE GMKDKMDELC KELLGPLRIP HNGIDTVKVG NRLWSPTIAG NNKRNLLKDI
     IIHTAKYRDM QRITSQYSDL LRRSALL
 
 
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