SLMA_ALIF1
ID SLMA_ALIF1 Reviewed; 196 AA.
AC Q5E8M7; Q5E8M8;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 3.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Nucleoid occlusion factor SlmA {ECO:0000255|HAMAP-Rule:MF_01839};
GN Name=slmA {ECO:0000255|HAMAP-Rule:MF_01839}; OrderedLocusNames=VF_0124;
GN ORFNames=VF0123;
OS Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Aliivibrio.
OX NCBI_TaxID=312309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700601 / ES114;
RX PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT pathogenic congeners.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=18366731; DOI=10.1186/1471-2164-9-138;
RA Mandel M.J., Stabb E.V., Ruby E.G.;
RT "Comparative genomics-based investigation of resequencing targets in Vibrio
RT fischeri: focus on point miscalls and artefactual expansions.";
RL BMC Genomics 9:138-138(2008).
CC -!- FUNCTION: Required for nucleoid occlusion (NO) phenomenon, which
CC prevents Z-ring formation and cell division over the nucleoid. Acts as
CC a DNA-associated cell division inhibitor that binds simultaneously
CC chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.
CC SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of
CC the chromosome, preventing FtsZ polymerization at these regions.
CC {ECO:0000255|HAMAP-Rule:MF_01839}.
CC -!- SUBUNIT: Homodimer. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC Rule:MF_01839}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01839}.
CC -!- SIMILARITY: Belongs to the nucleoid occlusion factor SlmA family.
CC {ECO:0000255|HAMAP-Rule:MF_01839}.
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DR EMBL; CP000020; AAW84619.2; -; Genomic_DNA.
DR RefSeq; WP_005417043.1; NC_006840.2.
DR RefSeq; YP_203507.2; NC_006840.2.
DR AlphaFoldDB; Q5E8M7; -.
DR SMR; Q5E8M7; -.
DR STRING; 312309.VF_0124; -.
DR EnsemblBacteria; AAW84619; AAW84619; VF_0124.
DR GeneID; 64241714; -.
DR KEGG; vfi:VF_0124; -.
DR PATRIC; fig|312309.11.peg.123; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_5_0_6; -.
DR OMA; IEQTVFG; -.
DR OrthoDB; 1437290at2; -.
DR Proteomes; UP000000537; Chromosome I.
DR GO; GO:0043590; C:bacterial nucleoid; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010974; P:negative regulation of division septum assembly; IEA:InterPro.
DR HAMAP; MF_01839; NO_factor_SlmA; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR023769; NO_SlmA.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; DNA-binding;
KW Reference proteome.
FT CHAIN 1..196
FT /note="Nucleoid occlusion factor SlmA"
FT /id="PRO_0000198984"
FT DOMAIN 7..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01839"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01839"
FT COILED 71..93
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01839"
SQ SEQUENCE 196 AA; 22790 MW; 8F48E4D86C466566 CRC64;
MATPRKPNRR DEILQALAEM LESNEGAARI TTAKLAKQVG VSEAALYRHF PSKAKMFEGL
IEFIEESIFS RVNRILEDEK DTLKRIELLL KLLLAFAERN PGLTRIMTGH ALMFENERLR
SRINQIFERI ELQFKQILRE RKLREGKAFP IDESILAAQL VGQVEGSFCR FVRSDFKYQP
TENFNEYWAL LSAQIQ
