BI51B_XENLA
ID BI51B_XENLA Reviewed; 160 AA.
AC Q4R1J6; Q5HZ94; Q8AXI6;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Baculoviral IAP repeat-containing protein 5.1-B;
DE AltName: Full=Survivin1-B {ECO:0000303|PubMed:15853809};
DE Short=Survivin {ECO:0000312|EMBL:AAN76690.1};
DE Short=XSurvivin1B {ECO:0000312|EMBL:BAE02678.1};
DE AltName: Full=xL_Survivin2 {ECO:0000303|PubMed:16759290};
DE Short=Su2 {ECO:0000303|PubMed:16759290};
GN Name=birc5.1-b; Synonyms=su2 {ECO:0000303|PubMed:16759290};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN76690.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Oocyte {ECO:0000269|PubMed:12454937};
RX PubMed=12454937; DOI=10.1002/dvdy.10194;
RA Murphy C.R., Sabel J.L., Sandler A.D., Dagle J.M.;
RT "Survivin mRNA is down-regulated during early Xenopus laevis
RT embryogenesis.";
RL Dev. Dyn. 225:597-601(2002).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Oocyte {ECO:0000269|PubMed:16759290};
RX PubMed=16759290; DOI=10.1111/j.1432-0436.2006.00073.x;
RA Du Pasquier D., Phung A.C., Ymlahi-Ouazzani Q., Sinzelle L., Ballagny C.,
RA Bronchain O., Du Pasquier L., Mazabraud A.;
RT "Survivin increased vascular development during Xenopus ontogenesis.";
RL Differentiation 74:244-253(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Oocyte;
RX PubMed=15853809; DOI=10.1111/j.1742-4658.2005.04648.x;
RA Tsuchiya Y., Murai S., Yamashita S.;
RT "Apoptosis-inhibiting activities of BIR family proteins in Xenopus egg
RT extracts.";
RL FEBS J. 272:2237-2250(2005).
RN [4] {ECO:0000312|EMBL:BAE02678.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000312|EMBL:AAH89127.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP REVIEW.
RX PubMed=16344111; DOI=10.1016/s0074-7696(05)47002-3;
RA Wheatley S.P., McNeish I.A.;
RT "Survivin: a protein with dual roles in mitosis and apoptosis.";
RL Int. Rev. Cytol. 247:35-88(2005).
CC -!- FUNCTION: Component of the chromosomal passenger complex (CPC), a
CC complex that acts as a key regulator of mitosis. The CPC complex has
CC essential functions at the centromere in ensuring correct chromosome
CC alignment and segregation and is required for chromatin-induced
CC microtubule stabilization and spindle assembly. Stimulates the mitotic
CC kinase activity of aurkb/aurora-B in the CPC. Does not appear to
CC exhibit anti-apoptotic activity (By similarity). CPC. Does not appear
CC to exhibit anti-apoptotic activity. {ECO:0000250,
CC ECO:0000269|PubMed:15853809}.
CC -!- SUBUNIT: Component of the CPC at least composed of survivin/birc5,
CC incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B.
CC Interacts directly with incenp (via N-terminus), and may weakly
CC interact with aurkb (via N-terminus) to stabilize the complex.
CC Interacts with GTP-bound ran in both the S and M phases of the cell
CC cycle. Also found in a complex with ubiquitin-mediated signaling
CC proteins including at least usp9x/xFAM, nploc4/npl4 and ufd1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15392}. Nucleus
CC {ECO:0000250|UniProtKB:O15392}. Chromosome, centromere
CC {ECO:0000250|UniProtKB:O15392}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres
CC from prophase through metaphase and then transferring to the spindle
CC midzone and midbody from anaphase through cytokinesis.
CC {ECO:0000250|UniProtKB:O15392}.
CC -!- DEVELOPMENTAL STAGE: Expressed maternally. Expressed in the earliest
CC stages of oocytes, and accumulates during oogenesis. Also present in
CC early embryos with expression declining rapidly after the onset of
CC zygotic transcription at the mid-blastula transition (MBT). Although
CC PubMed:12454937 conclude that, with the exception of the ovary,
CC expression is absent in adults, PubMed:16759290 suggest that expression
CC is adult-specific and is absent in embryonic and tadpole stages between
CC gastrulation and metamorphosis. {ECO:0000269|PubMed:12454937,
CC ECO:0000269|PubMed:16759290}.
CC -!- DOMAIN: C-terminus is required for spindle assembly.
CC {ECO:0000250|UniProtKB:Q8JGN5}.
CC -!- PTM: Ubiquitination is required for centrosome-targeting.
CC {ECO:0000250|UniProtKB:O15392}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89127.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF442492; AAN76690.1; -; mRNA.
DR EMBL; AB197248; BAE02678.1; -; mRNA.
DR EMBL; BC089127; AAH89127.1; ALT_INIT; mRNA.
DR RefSeq; NP_001082350.1; NM_001088881.1.
DR AlphaFoldDB; Q4R1J6; -.
DR SMR; Q4R1J6; -.
DR BioGRID; 99750; 1.
DR MEROPS; I32.005; -.
DR GeneID; 398418; -.
DR KEGG; xla:398418; -.
DR CTD; 398418; -.
DR Xenbase; XB-GENE-5851077; birc5.L.
DR OMA; FEGWPFD; -.
DR OrthoDB; 1404665at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 398418; Expressed in egg cell and 9 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR CDD; cd00022; BIR; 1.
DR InterPro; IPR001370; BIR_rpt.
DR Pfam; PF00653; BIR; 1.
DR SMART; SM00238; BIR; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Cytoplasm; Cytoskeleton; Metal-binding; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation; Zinc.
FT CHAIN 1..160
FT /note="Baculoviral IAP repeat-containing protein 5.1-B"
FT /id="PRO_0000382462"
FT REPEAT 13..83
FT /note="BIR"
FT /evidence="ECO:0000255"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 69
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 86
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O15392,
FT ECO:0000255|PROSITE-ProRule:PRU00029"
FT MOD_RES 43
FT /note="Phosphothreonine; by CDK1"
FT /evidence="ECO:0000250"
FT CONFLICT 20
FT /note="Missing (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="Q -> H (in Ref. 1; AAN76690)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 18803 MW; 7A538991C6190F5C CRC64;
MYSAKNRFVQ SVQRLQDFRN MYDYEARLAT FADWPFTENC KCTPENMAKA GFVHCPTENE
PDVACCFFCL KELEGWEPDD DPWNEHSKRS VNCGFLSLTK CVNDLTMEGF LRLEGDRIKS
FYRKFSTVVL QYVEEEMTAA TKRLLEYFSN QHQCSIDLDH
