BIA1_ARATH
ID BIA1_ARATH Reviewed; 435 AA.
AC O23393;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=BAHD acyltransferase BIA1 {ECO:0000303|PubMed:22956280};
DE EC=2.3.1.-;
DE AltName: Full=Protein ABNORMAL SHOOT 1 {ECO:0000303|PubMed:22956280};
DE AltName: Full=Protein BRASSINOSTEROID INACTIVATOR 1 {ECO:0000303|PubMed:22544867};
GN Name=BIA1 {ECO:0000303|PubMed:22544867};
GN Synonyms=ABS1 {ECO:0000303|PubMed:22956280};
GN OrderedLocusNames=At4g15400 {ECO:0000312|Araport:AT4G15400};
GN ORFNames=Dl3745c {ECO:0000312|EMBL:CAB10319.1},
GN FCAALL.284 {ECO:0000312|EMBL:CAB78582.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INDUCTION BY BRASSINOSTEROIDS, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=22956280; DOI=10.1093/jxb/ers227;
RA Wang M., Liu X., Wang R., Li W., Rodermel S., Yu F.;
RT "Overexpression of a putative Arabidopsis BAHD acyltransferase causes
RT dwarfism that can be rescued by brassinosteroid.";
RL J. Exp. Bot. 63:5787-5801(2012).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INDUCTION BY
RP DARKNESS AND BRASSINOSTEROIDS.
RC STRAIN=cv. Columbia;
RX PubMed=22544867; DOI=10.1104/pp.112.197202;
RA Roh H., Jeong C.W., Fujioka S., Kim Y.K., Lee S., Ahn J.H., Choi Y.D.,
RA Lee J.S.;
RT "Genetic evidence for the reduction of brassinosteroid levels by a BAHD
RT acyltransferase-like protein in Arabidopsis.";
RL Plant Physiol. 159:696-709(2012).
CC -!- FUNCTION: Monitors brassinosteroids (BR) responses and homeostasis,
CC particularly in the root and hypocotyl in darkness (PubMed:22956280,
CC PubMed:22544867). Promotes flavonoid biosynthesis (PubMed:22956280).
CC {ECO:0000269|PubMed:22544867, ECO:0000269|PubMed:22956280}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22544867,
CC ECO:0000269|PubMed:22956280}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots (particularly in the root
CC elongation zone), and, to a lower extent, in seedling, leaves
CC (especially in hydathodes), siliques (e.g. in developing seeds) and
CC flowers. {ECO:0000269|PubMed:22544867, ECO:0000269|PubMed:22956280}.
CC -!- INDUCTION: Accumulates in response to brassinosteroids (BR) treatment
CC (PubMed:22956280, PubMed:22544867). Induced by darkness in roots
CC (PubMed:22544867). {ECO:0000269|PubMed:22544867,
CC ECO:0000269|PubMed:22956280}.
CC -!- SIMILARITY: Belongs to the plant acyltransferase family. {ECO:0000305}.
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DR EMBL; Z97338; CAB10319.1; -; Genomic_DNA.
DR EMBL; AL161541; CAB78582.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83596.1; -; Genomic_DNA.
DR EMBL; BT023456; AAY56447.1; -; mRNA.
DR PIR; E71418; E71418.
DR RefSeq; NP_193275.1; NM_117628.4.
DR AlphaFoldDB; O23393; -.
DR SMR; O23393; -.
DR STRING; 3702.AT4G15400.1; -.
DR PaxDb; O23393; -.
DR PRIDE; O23393; -.
DR ProteomicsDB; 240343; -.
DR EnsemblPlants; AT4G15400.1; AT4G15400.1; AT4G15400.
DR GeneID; 827208; -.
DR Gramene; AT4G15400.1; AT4G15400.1; AT4G15400.
DR KEGG; ath:AT4G15400; -.
DR Araport; AT4G15400; -.
DR TAIR; locus:2130075; AT4G15400.
DR eggNOG; ENOG502QQQA; Eukaryota.
DR HOGENOM; CLU_014546_0_0_1; -.
DR InParanoid; O23393; -.
DR OMA; DRYIMSS; -.
DR OrthoDB; 1130893at2759; -.
DR PhylomeDB; O23393; -.
DR BioCyc; ARA:AT4G15400-MON; -.
DR PRO; PR:O23393; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O23393; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0010268; P:brassinosteroid homeostasis; IMP:UniProtKB.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IMP:TAIR.
DR GO; GO:0016131; P:brassinosteroid metabolic process; IMP:TAIR.
DR GO; GO:0010422; P:regulation of brassinosteroid biosynthetic process; IMP:UniProtKB.
DR GO; GO:0009962; P:regulation of flavonoid biosynthetic process; IMP:UniProtKB.
DR GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
DR GO; GO:0009741; P:response to brassinosteroid; IEP:UniProtKB.
DR Gene3D; 3.30.559.10; -; 2.
DR InterPro; IPR023213; CAT-like_dom_sf.
PE 2: Evidence at transcript level;
KW Acyltransferase; Brassinosteroid signaling pathway; Cytoplasm;
KW Reference proteome; Transferase.
FT CHAIN 1..435
FT /note="BAHD acyltransferase BIA1"
FT /id="PRO_0000440168"
FT ACT_SITE 151
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
FT ACT_SITE 369
FT /note="Proton acceptor"
FT /evidence="ECO:0000255"
SQ SEQUENCE 435 AA; 48023 MW; CBAD10E4D3085580 CRC64;
MEAKLEVTGK EVIKPASPSP RDRLQLSILD LYCPGIYVST IFFYDLITES SEVFSENLKL
SLSETLSRFY PLAGRIEGLS ISCNDEGAVF TEARTDLLLP DFLRNLNTDS LSGFLPTLAA
GESPAAWPLL SVKVTFFGSG SGVAVSVSVS HKICDIASLV TFVKDWATTT AKGKSNSTIE
FAETTIYPPP PSHMYEQFPS TDSDSNITSK YVLKRFVFEP SKIAELKHKA ASESVPVPTR
VEAIMSLIWR CARNSSRSNL LIPRQAVMWQ AMDIRLRIPS SVAPKDVIGN LQSGFSLKKD
AESEFEIPEI VATFRKNKER VNEMIKESLQ GNTIGQSLLS LMAETVSEST EIDRYIMSSW
CRKPFYEVDF GSGSPVWVGY ASHTIYDNMV GVVLIDSKEG DGVEAWISLP EEDMSVFVDD
QELLAYAVLN PPVVA
