BIC1A_XENLA
ID BIC1A_XENLA Reviewed; 963 AA.
AC Q9IA00;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein bicaudal C homolog 1-A;
DE Short=Bic-C-A;
GN Name=bicc1-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Yolk;
RX PubMed=10769230; DOI=10.1242/dev.127.10.2053;
RA Wessely O., De Robertis E.M.;
RT "The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can
RT induce endoderm formation.";
RL Development 127:2053-2062(2000).
CC -!- FUNCTION: Putative RNA-binding protein. May be involved in regulating
CC gene expression during embryonic development. Seems to be involved in
CC endoderm formation. Ectopic expression results in endoderm formation in
CC the absence of mesoderm induction. {ECO:0000269|PubMed:10769230}.
CC -!- DEVELOPMENTAL STAGE: Is enriched in the vegetal half of the oocyte. In
CC stage II oocytes is present uniformly in the cytoplasm; at stage III,
CC it is concentrated towards the vegetal pole and finally clearly
CC accumulates in the vegetal cortex by stage IV and V. It is expressed
CC throughout the oocyte cytoplasm, forming a vegetal-to-animal gradient.
CC After fertilization, persists in the yolky endodermal cells until mid-
CC blastula-transition (MBT). At MBT, is abundant in the large endodermal
CC cells. By the gastrula stage, this endodermal core is found in the
CC center of the embryo. At stage 12, is also independently expressed in
CC the late dorsal blastopore lip. This expression continues in the
CC midline of the neural tube and finally regresses to the tip of the
CC tail. At stage 30 expressed in the floorplate. At tailbud stage,
CC expression is also detected in the pronephros and pronephric duct.
CC {ECO:0000269|PubMed:10769230}.
CC -!- SIMILARITY: Belongs to the BicC family. {ECO:0000305}.
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DR EMBL; AF224746; AAF69826.1; -; mRNA.
DR RefSeq; NP_001081996.1; NM_001088527.1.
DR AlphaFoldDB; Q9IA00; -.
DR SMR; Q9IA00; -.
DR PRIDE; Q9IA00; -.
DR GeneID; 398169; -.
DR KEGG; xla:398169; -.
DR CTD; 398169; -.
DR Xenbase; XB-GENE-6251921; bicc1.S.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 398169; Expressed in egg cell and 19 other tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 3.30.1370.10; -; 1.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF54791; SSF54791; 3.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..963
FT /note="Protein bicaudal C homolog 1-A"
FT /id="PRO_0000267716"
FT DOMAIN 128..195
FT /note="KH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 280..344
FT /note="KH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 862..925
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 105016 MW; 475CEF9139ACECCD CRC64;
MAAQCESIGG DMNQSDPGSN SERSADSPVP GSEDDSPHDP EWREERFRVD RKKLETMLQA
AAEGKGKSGE DFFQKIMEET NTQIAWPSKL KIGAKSKKDP HIKVSGKKEN VKEAKERIMS
VLDTKSNRVT LKMDVLHTEH SHVIGKGGNN IKKVMEETGC HIHFPDSNRN NQAEKSNQVS
IAGQPAGVES ARVRIRELLP LVLMFELPIA GILQPIPDPN SPTIQQISQT YNLTVSFKQR
SRVYGATVIV RGSQNNTSAV KEGTAMLLEH LAGSLATAIP VSTQLDIAAQ HHLFMMGRNG
CNIKHIMQRT GAQIHFPDPN NPLKKSTVYL QGTIDSVCLA RQYLMGCLPL VLMFDMKEEI
EIEPQCITQL MEQLDVFISI KPKPKQPSKS VIVKSVERNA LNMYEARKCL LGLDSSGVTV
TNQSTLSCPV PMNCHGLDIL AAGLGLSGLG LLGPNTLSVN STTAQNSLLN ALNSSLSPLH
SPSSAAPSPT LWAASLANNA TGFSAIPHLM IPSAAQATLT NFLLSGVPNY GQNTPSPPPG
LTPVDVHMNG IHSECKKVTS ALNGHVKPTN MKYGTISSSS LGDKVLNTNL AEASRQSNNH
SSAEEVNSKT DPEGCNDAFV EVGMPRSPSH SANTKDLKQM LNSTKAPCPT RQTVKLLHGT
KNSHLHGERL LSDSEMSPME GPVTDKKAPG SERAAERAAA QQNSERARLT SQSEYGTMQA
YDYEQKKLLA TKAMLKKPVV TEVRTPTNTW SGLGFSKSTP AETIKELRRA NHVPYKPTMT
TTYENSSLSR SNSREQLGNG SDSENWRERN GIDSSQNDYS SSIGSPKRKQ NKSAEHYLSS
SNYMDCISSL TGSNGCNLNS SFKGSDLPEL FSKLGLGKYT DIFQQQEIDL QTFLTLTDQD
LKELGISTFG ARRKMLLAIS ELNKNRRKLF EPTNIRASFL EGGASGRLPR QYHTDIASVS
GRW
