ID   BIC1B_XENLA             Reviewed;         970 AA.
AC   Q5U4T7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein bicaudal C homolog 1-B;
DE            Short=Bic-C-B;
GN   Name=bicc1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative RNA-binding protein. May be involved in regulating
CC       gene expression during embryonic development. Seems to be involved in
CC       endoderm formation. Ectopic expression results in endoderm formation in
CC       the absence of mesoderm induction (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BicC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC084957; AAH84957.1; -; mRNA.
DR   RefSeq; NP_001088559.1; NM_001095090.1.
DR   AlphaFoldDB; Q5U4T7; -.
DR   SMR; Q5U4T7; -.
DR   PRIDE; Q5U4T7; -.
DR   DNASU; 495436; -.
DR   GeneID; 495436; -.
DR   KEGG; xla:495436; -.
DR   CTD; 495436; -.
DR   Xenbase; XB-GENE-865790; bicc1.L.
DR   OrthoDB; 201055at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 495436; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd09520; SAM_BICC1; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR037974; BICC1_SAM_dom.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF00013; KH_1; 2.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00322; KH; 3.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF54791; SSF54791; 3.
DR   PROSITE; PS50084; KH_TYPE_1; 2.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..970
FT                   /note="Protein bicaudal C homolog 1-B"
FT                   /id="PRO_0000267717"
FT   DOMAIN          130..197
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          282..346
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          869..932
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          677..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          773..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..812
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  105728 MW;  6260BC64665458DC CRC64;
     MAAQCGGYMN QSDPGSNSER SADSPLPGSE DDSPGSAAPH DPEWREERFR VDRKKLETML
     QAAAEGKGKS GEDFFQKIME ETNTQIAWPS KLKIGAKSKK DPHIKVSGKK ENVKEAKERI
     MSVLDTKSNR VTLKMDVSHT EHSHVIGKGG NNIKKVMEET GCHIHFPDSN RNNQAEKSNQ
     VSIAGQPAGV ESARVRIREL LPLVLMFELP IAGILQPIPD PNSPTIQQIS QTYNITVSFK
     QRSRVYGATV IVRGSQNNTS AVKEGTAMLL EHLAGSLASA IPVSTQLDIA AQHHLFMMGR
     NGCNIKHIMQ RTGAQIHFPD PNNPLKKSTV YLQGTIESVC LARQYLMGCL PLVLMFDMKE
     EIEVEPQCIT QLMEQLDVFI SIKPKPKQPS KSVIVKSVER NALNMYEARK CLLGLDSSGV
     TITNQSTISC PIPMNCHGLD ILAAGLGLSG LGLLGPNTLS VNSTTAQNSL LNALNSSVSP
     LHSPSSAAPS PTLWATSLAN TSNATGFPAI PHLMIPSAAQ ATLTNFLLSG VPNYGQNTPS
     PPPGLTPVDV HMNGLHSECK KVTSVLNGHV KPTNMKYGTI SSSSLGDKVL NTNLAEASRQ
     SNNHSSAEEV NSKTDSEGCN DAFVEVGMPR SPSHSANTKD LKQMLNSTKA PCPTRQTVKL
     LHGTKNSHLH TAERLLSDSE MSPTEGPMTD KKAPGSERAA ERAAAQHNCE MARFTSQSAY
     GNMQAYDYEQ KKLLATKAML KKPVVTEVRT PTNTWSGLGF SKSMPAETIK ELRRANHVPY
     KPTMSTTYEN SPMSLSRSNS REQLGNGSDS DNWRERNGID SSHNDYSSSI GSPKRKQNKS
     AEHYLSSSNY MDCISSLTGS NGCNLNSSFK GSDLPELFSK LGLGKYTDIF QQQEIDLQTF
     LTLTDQDLKE LGITTFGARR KMLLAISELN KNRRKLFEPT NIRSSFLEGG ASGRLPRQYH
     TDIASVSGRW