BIC1_ARATH
ID BIC1_ARATH Reviewed; 140 AA.
AC Q9LXJ1;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein BIC1 {ECO:0000303|PubMed:27846570};
DE AltName: Full=BLUE-LIGHT INHIBITOR OF CRYPTOCHROMES 1 {ECO:0000303|PubMed:27846570};
GN Name=BIC1 {ECO:0000303|PubMed:27846570};
GN OrderedLocusNames=At3g52740 {ECO:0000312|Araport:AT3G52740};
GN ORFNames=F3C22.140 {ECO:0000312|EMBL:CAB89235.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND INTERACTION WITH
RP CRY2.
RX PubMed=27846570; DOI=10.1126/science.aaf9030;
RA Wang Q., Zuo Z., Wang X., Gu L., Yoshizumi T., Yang Z., Yang L., Liu Q.,
RA Liu W., Han Y.J., Kim J.I., Liu B., Wohlschlegel J.A., Matsui M., Oka Y.,
RA Lin C.;
RT "Photoactivation and inactivation of Arabidopsis cryptochrome 2.";
RL Science 354:343-347(2016).
CC -!- FUNCTION: Regulates the blue-light dependent dimerization of CRY2 and
CC formation of photobodies. Interacts with photoexited CRY2 to inhibit
CC its activity. Inhibits CRY phosphorylation.
CC {ECO:0000269|PubMed:27846570}.
CC -!- SUBUNIT: Interacts with CRY2 in both darkness and light.
CC {ECO:0000269|PubMed:27846570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27846570}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Bic1 and bic2 double
CC mutants have a blue light-hypersensitive short-hypocotyl phenotype and
CC an increased anthocyanin accumulation when grown in continuous blue
CC light. {ECO:0000269|PubMed:27846570}.
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DR EMBL; AL353912; CAB89235.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78988.1; -; Genomic_DNA.
DR EMBL; AY052695; AAK96599.1; -; mRNA.
DR EMBL; AF446877; AAL38610.1; -; mRNA.
DR PIR; T49027; T49027.
DR RefSeq; NP_566972.1; NM_115134.3.
DR AlphaFoldDB; Q9LXJ1; -.
DR SMR; Q9LXJ1; -.
DR IntAct; Q9LXJ1; 6.
DR STRING; 3702.AT3G52740.1; -.
DR PaxDb; Q9LXJ1; -.
DR PRIDE; Q9LXJ1; -.
DR ProteomicsDB; 240376; -.
DR EnsemblPlants; AT3G52740.1; AT3G52740.1; AT3G52740.
DR GeneID; 824440; -.
DR Gramene; AT3G52740.1; AT3G52740.1; AT3G52740.
DR KEGG; ath:AT3G52740; -.
DR Araport; AT3G52740; -.
DR TAIR; locus:2083243; AT3G52740.
DR eggNOG; ENOG502S7HB; Eukaryota.
DR HOGENOM; CLU_128475_2_0_1; -.
DR InParanoid; Q9LXJ1; -.
DR OMA; KKHRREI; -.
DR OrthoDB; 1349509at2759; -.
DR PhylomeDB; Q9LXJ1; -.
DR PRO; PR:Q9LXJ1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LXJ1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009785; P:blue light signaling pathway; IEA:InterPro.
DR InterPro; IPR040374; BIC.
DR PANTHER; PTHR34207; PTHR34207; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..140
FT /note="Protein BIC1"
FT /id="PRO_0000438703"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 140 AA; 15512 MW; B374E6B3DA70271E CRC64;
MMNIDDTTSP MAHPIGPSQP PSDQTKQDPP SLPQEAASSV SADKKDLALL EEKPKQSQEE
DRVDTGRERL KKHRREIAGR VWIPEIWGQE ELLKDWIDCS TFDTCLVPAG ISSARTALVE
EARRAASASG GLHNRCLILR
