SLMO_DROME
ID SLMO_DROME Reviewed; 215 AA.
AC Q9V3U9; Q058T1;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein slowmo;
GN Name=slmo; Synonyms=kisir; ORFNames=CG9131;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=14673704; DOI=10.1007/s10158-003-0028-y;
RA Carhan A., Reeve S., Dee C.T., Baines R.A., Moffat K.G.;
RT "Mutation in slowmo causes defects in Drosophila larval locomotor
RT behaviour.";
RL Invertebr. Neurosci. 5:65-75(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17245774; DOI=10.1002/dvg.20265;
RA Reeve S., Carhan A., Dee C.T., Moffat K.G.;
RT "Slowmo is required for Drosophila germline proliferation.";
RL Genesis 45:66-75(2007).
CC -!- FUNCTION: Required to regulate peristaltic movement and also for
CC germline proliferation in males and females.
CC {ECO:0000269|PubMed:14673704, ECO:0000269|PubMed:17245774}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14673704}.
CC -!- TISSUE SPECIFICITY: Expressed in specific tissues such as the
CC developing central nervous system (CNS) and both the male and female
CC germline. In the CNS, it is restricted in a subset of cells during
CC embryogenesis and early larval development. In embryos, it is also
CC expressed in salivary glands. In the testis, expressed in somatic cyst
CC cells throughout the distal region where the mitotic cysts develop,
CC extending through to meiotic cysts. {ECO:0000269|PubMed:14673704,
CC ECO:0000269|PubMed:17245774}.
CC -!- DEVELOPMENTAL STAGE: Expressed from stage 16 embryos.
CC -!- DISRUPTION PHENOTYPE: Flies have defects in locomotor behavior and die
CC during larval development, due to abnormal neural function. Mutant
CC males lacking functional slmo survive into adulthood and show an early
CC division of the germline but never progress through the gonial
CC divisions. Mutant females demonstrate germarial degeneration and
CC reduced fertility. {ECO:0000269|PubMed:14673704}.
CC -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
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DR EMBL; AF218125; AAF23180.1; -; mRNA.
DR EMBL; AE014134; AAF52330.1; -; Genomic_DNA.
DR EMBL; AY051484; AAK92908.1; -; mRNA.
DR EMBL; BT029137; ABJ17070.1; -; mRNA.
DR RefSeq; NP_001097094.1; NM_001103624.2.
DR RefSeq; NP_001137793.1; NM_001144321.2.
DR RefSeq; NP_001285653.1; NM_001298724.1.
DR RefSeq; NP_524705.1; NM_079966.3.
DR RefSeq; NP_723148.1; NM_164677.2.
DR AlphaFoldDB; Q9V3U9; -.
DR SMR; Q9V3U9; -.
DR BioGRID; 68852; 1.
DR IntAct; Q9V3U9; 1.
DR STRING; 7227.FBpp0111858; -.
DR PaxDb; Q9V3U9; -.
DR DNASU; 44132; -.
DR EnsemblMetazoa; FBtr0079217; FBpp0078848; FBgn0029161.
DR EnsemblMetazoa; FBtr0079218; FBpp0078849; FBgn0029161.
DR EnsemblMetazoa; FBtr0112945; FBpp0111858; FBgn0029161.
DR EnsemblMetazoa; FBtr0299810; FBpp0289088; FBgn0029161.
DR EnsemblMetazoa; FBtr0343130; FBpp0309829; FBgn0029161.
DR GeneID; 44132; -.
DR KEGG; dme:Dmel_CG9131; -.
DR UCSC; CG9131-RA; d. melanogaster.
DR CTD; 44132; -.
DR FlyBase; FBgn0029161; slmo.
DR VEuPathDB; VectorBase:FBgn0029161; -.
DR eggNOG; KOG3336; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_1_0_1; -.
DR InParanoid; Q9V3U9; -.
DR OMA; AMSRRVF; -.
DR PhylomeDB; Q9V3U9; -.
DR Reactome; R-DME-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR SignaLink; Q9V3U9; -.
DR BioGRID-ORCS; 44132; 2 hits in 3 CRISPR screens.
DR GenomeRNAi; 44132; -.
DR PRO; PR:Q9V3U9; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0029161; Expressed in testis and 26 other tissues.
DR ExpressionAtlas; Q9V3U9; baseline.
DR Genevisible; Q9V3U9; DM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IMP:UniProtKB.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR GO; GO:0030706; P:germarium-derived oocyte differentiation; IMP:FlyBase.
DR GO; GO:0008345; P:larval locomotory behavior; IMP:UniProtKB.
DR GO; GO:0030432; P:peristalsis; IMP:UniProtKB.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IMP:FlyBase.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Mitochondrion; Oogenesis;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..215
FT /note="Protein slowmo"
FT /id="PRO_0000071958"
FT DOMAIN 1..170
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
SQ SEQUENCE 215 AA; 24305 MW; 5CFBCC2791963EC5 CRC64;
MKIWTSEHIF NHPWETVTQA AWRKYPNPMT PSIIGTDVVE RRVVDGVLHT HRLVQSKWYF
PKWTHALIGT AKTCFASERS TVDPERKQMV LKTNNLTFCR NISVDEVLYY EPHPSDASKT
LLKQEATVTV FGVPLSHYME DLLTSTISTN AGKGRQGLEW VIGLINTEVK GIARGTDELL
HNTRRSIDEV TESARKSMDE ISAQAAKAAK AMHIT