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SLMO_DROME
ID   SLMO_DROME              Reviewed;         215 AA.
AC   Q9V3U9; Q058T1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protein slowmo;
GN   Name=slmo; Synonyms=kisir; ORFNames=CG9131;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=14673704; DOI=10.1007/s10158-003-0028-y;
RA   Carhan A., Reeve S., Dee C.T., Baines R.A., Moffat K.G.;
RT   "Mutation in slowmo causes defects in Drosophila larval locomotor
RT   behaviour.";
RL   Invertebr. Neurosci. 5:65-75(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17245774; DOI=10.1002/dvg.20265;
RA   Reeve S., Carhan A., Dee C.T., Moffat K.G.;
RT   "Slowmo is required for Drosophila germline proliferation.";
RL   Genesis 45:66-75(2007).
CC   -!- FUNCTION: Required to regulate peristaltic movement and also for
CC       germline proliferation in males and females.
CC       {ECO:0000269|PubMed:14673704, ECO:0000269|PubMed:17245774}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14673704}.
CC   -!- TISSUE SPECIFICITY: Expressed in specific tissues such as the
CC       developing central nervous system (CNS) and both the male and female
CC       germline. In the CNS, it is restricted in a subset of cells during
CC       embryogenesis and early larval development. In embryos, it is also
CC       expressed in salivary glands. In the testis, expressed in somatic cyst
CC       cells throughout the distal region where the mitotic cysts develop,
CC       extending through to meiotic cysts. {ECO:0000269|PubMed:14673704,
CC       ECO:0000269|PubMed:17245774}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from stage 16 embryos.
CC   -!- DISRUPTION PHENOTYPE: Flies have defects in locomotor behavior and die
CC       during larval development, due to abnormal neural function. Mutant
CC       males lacking functional slmo survive into adulthood and show an early
CC       division of the germline but never progress through the gonial
CC       divisions. Mutant females demonstrate germarial degeneration and
CC       reduced fertility. {ECO:0000269|PubMed:14673704}.
CC   -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
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DR   EMBL; AF218125; AAF23180.1; -; mRNA.
DR   EMBL; AE014134; AAF52330.1; -; Genomic_DNA.
DR   EMBL; AY051484; AAK92908.1; -; mRNA.
DR   EMBL; BT029137; ABJ17070.1; -; mRNA.
DR   RefSeq; NP_001097094.1; NM_001103624.2.
DR   RefSeq; NP_001137793.1; NM_001144321.2.
DR   RefSeq; NP_001285653.1; NM_001298724.1.
DR   RefSeq; NP_524705.1; NM_079966.3.
DR   RefSeq; NP_723148.1; NM_164677.2.
DR   AlphaFoldDB; Q9V3U9; -.
DR   SMR; Q9V3U9; -.
DR   BioGRID; 68852; 1.
DR   IntAct; Q9V3U9; 1.
DR   STRING; 7227.FBpp0111858; -.
DR   PaxDb; Q9V3U9; -.
DR   DNASU; 44132; -.
DR   EnsemblMetazoa; FBtr0079217; FBpp0078848; FBgn0029161.
DR   EnsemblMetazoa; FBtr0079218; FBpp0078849; FBgn0029161.
DR   EnsemblMetazoa; FBtr0112945; FBpp0111858; FBgn0029161.
DR   EnsemblMetazoa; FBtr0299810; FBpp0289088; FBgn0029161.
DR   EnsemblMetazoa; FBtr0343130; FBpp0309829; FBgn0029161.
DR   GeneID; 44132; -.
DR   KEGG; dme:Dmel_CG9131; -.
DR   UCSC; CG9131-RA; d. melanogaster.
DR   CTD; 44132; -.
DR   FlyBase; FBgn0029161; slmo.
DR   VEuPathDB; VectorBase:FBgn0029161; -.
DR   eggNOG; KOG3336; Eukaryota.
DR   GeneTree; ENSGT00950000182810; -.
DR   HOGENOM; CLU_067902_1_0_1; -.
DR   InParanoid; Q9V3U9; -.
DR   OMA; AMSRRVF; -.
DR   PhylomeDB; Q9V3U9; -.
DR   Reactome; R-DME-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR   SignaLink; Q9V3U9; -.
DR   BioGRID-ORCS; 44132; 2 hits in 3 CRISPR screens.
DR   GenomeRNAi; 44132; -.
DR   PRO; PR:Q9V3U9; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0029161; Expressed in testis and 26 other tissues.
DR   ExpressionAtlas; Q9V3U9; baseline.
DR   Genevisible; Q9V3U9; DM.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IMP:UniProtKB.
DR   GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR   GO; GO:0030706; P:germarium-derived oocyte differentiation; IMP:FlyBase.
DR   GO; GO:0008345; P:larval locomotory behavior; IMP:UniProtKB.
DR   GO; GO:0030432; P:peristalsis; IMP:UniProtKB.
DR   GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IMP:FlyBase.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   InterPro; IPR037365; Slowmo/Ups.
DR   PANTHER; PTHR11158; PTHR11158; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Mitochondrion; Oogenesis;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..215
FT                   /note="Protein slowmo"
FT                   /id="PRO_0000071958"
FT   DOMAIN          1..170
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
SQ   SEQUENCE   215 AA;  24305 MW;  5CFBCC2791963EC5 CRC64;
     MKIWTSEHIF NHPWETVTQA AWRKYPNPMT PSIIGTDVVE RRVVDGVLHT HRLVQSKWYF
     PKWTHALIGT AKTCFASERS TVDPERKQMV LKTNNLTFCR NISVDEVLYY EPHPSDASKT
     LLKQEATVTV FGVPLSHYME DLLTSTISTN AGKGRQGLEW VIGLINTEVK GIARGTDELL
     HNTRRSIDEV TESARKSMDE ISAQAAKAAK AMHIT
 
 
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