BIC2_ARATH
ID BIC2_ARATH Reviewed; 116 AA.
AC Q9M280;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein BIC2 {ECO:0000303|PubMed:27846570};
DE AltName: Full=BLUE-LIGHT INHIBITOR OF CRYPTOCHROMES 2 {ECO:0000303|PubMed:27846570};
GN Name=BIC2 {ECO:0000303|PubMed:27846570};
GN OrderedLocusNames=At3g44450 {ECO:0000312|Araport:AT3G44450};
GN ORFNames=T22K7.130 {ECO:0000312|EMBL:CAB86923.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=27846570; DOI=10.1126/science.aaf9030;
RA Wang Q., Zuo Z., Wang X., Gu L., Yoshizumi T., Yang Z., Yang L., Liu Q.,
RA Liu W., Han Y.J., Kim J.I., Liu B., Wohlschlegel J.A., Matsui M., Oka Y.,
RA Lin C.;
RT "Photoactivation and inactivation of Arabidopsis cryptochrome 2.";
RL Science 354:343-347(2016).
CC -!- FUNCTION: Regulates the blue-light dependent dimerization of CRY2 and
CC formation of photobodies. Inhibits CRY phosphorylation.
CC {ECO:0000269|PubMed:27846570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27846570}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Bic1 and bic2 double
CC mutants have a blue light-hypersensitive short-hypocotyl phenotype and
CC an increased anthocyanin accumulation when grown in continuous blue
CC light. {ECO:0000269|PubMed:27846570}.
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DR EMBL; AL138641; CAB86923.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77904.1; -; Genomic_DNA.
DR EMBL; BT012513; AAS99657.1; -; mRNA.
DR EMBL; BT014814; AAT41797.1; -; mRNA.
DR PIR; T47435; T47435.
DR RefSeq; NP_190031.1; NM_114313.5.
DR PDB; 6K8K; X-ray; 2.50 A; C/E/F/H=33-97.
DR PDBsum; 6K8K; -.
DR AlphaFoldDB; Q9M280; -.
DR SMR; Q9M280; -.
DR STRING; 3702.AT3G44450.1; -.
DR PaxDb; Q9M280; -.
DR PRIDE; Q9M280; -.
DR EnsemblPlants; AT3G44450.1; AT3G44450.1; AT3G44450.
DR GeneID; 823570; -.
DR Gramene; AT3G44450.1; AT3G44450.1; AT3G44450.
DR KEGG; ath:AT3G44450; -.
DR Araport; AT3G44450; -.
DR TAIR; locus:2100167; AT3G44450.
DR eggNOG; ENOG502S7VQ; Eukaryota.
DR HOGENOM; CLU_2100247_0_0_1; -.
DR InParanoid; Q9M280; -.
DR OMA; GWMDFST; -.
DR OrthoDB; 1558363at2759; -.
DR PhylomeDB; Q9M280; -.
DR PRO; PR:Q9M280; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M280; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009785; P:blue light signaling pathway; IGI:TAIR.
DR InterPro; IPR040374; BIC.
DR PANTHER; PTHR34207; PTHR34207; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome.
FT CHAIN 1..116
FT /note="Protein BIC2"
FT /id="PRO_0000438704"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 40..51
FT /evidence="ECO:0007829|PDB:6K8K"
FT HELIX 64..66
FT /evidence="ECO:0007829|PDB:6K8K"
FT TURN 67..69
FT /evidence="ECO:0007829|PDB:6K8K"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:6K8K"
FT HELIX 83..94
FT /evidence="ECO:0007829|PDB:6K8K"
SQ SEQUENCE 116 AA; 12696 MW; 6E43AAD0115740F6 CRC64;
MKNTNLPEET KEPISPGSSH RKQNKTGTKT CFPETTVLSG RDRLKRHREE VAGKVPIPDS
WGKEGLLMGW MDFSTFDAAF TSSQIVSARA ALMADSGDDA GARGSRPQRL RVESSC
