SLNL1_HUMAN
ID SLNL1_HUMAN Reviewed; 407 AA.
AC Q499Z3; A8K8D1; Q49AG8; Q5VW72; Q5VW74; Q8N7V7; Q8TCH6; Q8WVZ8;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Schlafen-like protein 1;
GN Name=SLFNL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4), AND VARIANT
RP THR-30.
RC TISSUE=Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP SER-128.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q499Z3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q499Z3-2; Sequence=VSP_024276;
CC Name=3;
CC IsoId=Q499Z3-3; Sequence=VSP_024278;
CC Name=4;
CC IsoId=Q499Z3-4; Sequence=VSP_024275, VSP_024277;
CC -!- SIMILARITY: Belongs to the Schlafen family. Subgroup I subfamily.
CC {ECO:0000305}.
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DR EMBL; AK074458; BAB85090.1; -; mRNA.
DR EMBL; AK097609; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK292296; BAF84985.1; -; mRNA.
DR EMBL; AL391730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022037; AAH22037.2; -; mRNA.
DR EMBL; BC037879; AAH37879.1; -; mRNA.
DR EMBL; BC050353; AAH50353.1; -; mRNA.
DR CCDS; CCDS460.1; -. [Q499Z3-1]
DR CCDS; CCDS72766.1; -. [Q499Z3-2]
DR RefSeq; NP_001161719.1; NM_001168247.2. [Q499Z3-1]
DR RefSeq; NP_001287788.1; NM_001300859.1. [Q499Z3-2]
DR RefSeq; NP_659427.3; NM_144990.3. [Q499Z3-1]
DR RefSeq; XP_005270654.1; XM_005270597.2.
DR RefSeq; XP_005270655.1; XM_005270598.2. [Q499Z3-1]
DR RefSeq; XP_005270656.1; XM_005270599.2. [Q499Z3-1]
DR RefSeq; XP_006710495.1; XM_006710432.3. [Q499Z3-1]
DR RefSeq; XP_011539245.1; XM_011540943.1.
DR RefSeq; XP_011539247.1; XM_011540945.1. [Q499Z3-1]
DR RefSeq; XP_011539249.1; XM_011540947.1. [Q499Z3-1]
DR RefSeq; XP_011539250.1; XM_011540948.1. [Q499Z3-1]
DR RefSeq; XP_011539251.1; XM_011540949.1. [Q499Z3-1]
DR RefSeq; XP_011539252.1; XM_011540950.1.
DR RefSeq; XP_011539253.1; XM_011540951.1. [Q499Z3-1]
DR RefSeq; XP_011539254.1; XM_011540952.2. [Q499Z3-1]
DR RefSeq; XP_011539255.1; XM_011540953.2. [Q499Z3-1]
DR RefSeq; XP_011539256.1; XM_011540954.1.
DR RefSeq; XP_016856062.1; XM_017000573.1.
DR AlphaFoldDB; Q499Z3; -.
DR BioGRID; 128306; 2.
DR STRING; 9606.ENSP00000352299; -.
DR iPTMnet; Q499Z3; -.
DR PhosphoSitePlus; Q499Z3; -.
DR BioMuta; SLFNL1; -.
DR DMDM; 143585411; -.
DR MassIVE; Q499Z3; -.
DR PaxDb; Q499Z3; -.
DR PeptideAtlas; Q499Z3; -.
DR PRIDE; Q499Z3; -.
DR ProteomicsDB; 62007; -. [Q499Z3-1]
DR ProteomicsDB; 62008; -. [Q499Z3-2]
DR ProteomicsDB; 62009; -. [Q499Z3-3]
DR ProteomicsDB; 62010; -. [Q499Z3-4]
DR Antibodypedia; 32165; 273 antibodies from 25 providers.
DR DNASU; 200172; -.
DR Ensembl; ENST00000302946.13; ENSP00000304401.8; ENSG00000171790.16. [Q499Z3-1]
DR Ensembl; ENST00000359345.5; ENSP00000352299.1; ENSG00000171790.16. [Q499Z3-1]
DR Ensembl; ENST00000372611.5; ENSP00000361694.1; ENSG00000171790.16. [Q499Z3-2]
DR Ensembl; ENST00000372613.6; ENSP00000361696.2; ENSG00000171790.16. [Q499Z3-3]
DR Ensembl; ENST00000439569.2; ENSP00000398938.2; ENSG00000171790.16. [Q499Z3-1]
DR GeneID; 200172; -.
DR KEGG; hsa:200172; -.
DR MANE-Select; ENST00000302946.13; ENSP00000304401.8; NM_144990.4; NP_659427.3.
DR UCSC; uc001cgn.3; human. [Q499Z3-1]
DR CTD; 200172; -.
DR DisGeNET; 200172; -.
DR GeneCards; SLFNL1; -.
DR HGNC; HGNC:26313; SLFNL1.
DR HPA; ENSG00000171790; Tissue enriched (testis).
DR neXtProt; NX_Q499Z3; -.
DR OpenTargets; ENSG00000171790; -.
DR PharmGKB; PA144596362; -.
DR VEuPathDB; HostDB:ENSG00000171790; -.
DR eggNOG; ENOG502QTT1; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR HOGENOM; CLU_034269_0_0_1; -.
DR InParanoid; Q499Z3; -.
DR OMA; NETRNME; -.
DR PhylomeDB; Q499Z3; -.
DR TreeFam; TF337569; -.
DR PathwayCommons; Q499Z3; -.
DR BioGRID-ORCS; 200172; 35 hits in 1068 CRISPR screens.
DR ChiTaRS; SLFNL1; human.
DR GenomeRNAi; 200172; -.
DR Pharos; Q499Z3; Tdark.
DR PRO; PR:Q499Z3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q499Z3; protein.
DR Bgee; ENSG00000171790; Expressed in sperm and 129 other tissues.
DR ExpressionAtlas; Q499Z3; baseline and differential.
DR Genevisible; Q499Z3; HS.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.950.30; -; 1.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR029667; SLFNL1.
DR PANTHER; PTHR12155; PTHR12155; 1.
DR PANTHER; PTHR12155:SF29; PTHR12155:SF29; 1.
DR Pfam; PF04326; AlbA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Coiled coil; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..407
FT /note="Schlafen-like protein 1"
FT /id="PRO_0000282998"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 366..398
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 261..268
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 146..260
FT /note="EKEEEEEDSGLSPGPSPGSGVPLPTWPTHTLPDRPQAQQLQSCQGRPSGVCS
FT DSAIVHQQIVGKDQLFQGAFLGSETRNMEFKRGSGEYLSLAFKHHVRRYVCAFLNSEGG
FT SLLV -> VSGTFPKQAPKPHPKGEPLSGSGLQSGDGGVSLGKQGQICKLGGCHSNDHG
FT LRLVLPAFSGKNSLPQAQARRLCEERPRGDLLSLGPFTFQPLGLGDPRRHRGPDFLLGP
FT THLFN (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024275"
FT VAR_SEQ 146..204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024276"
FT VAR_SEQ 261..407
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024277"
FT VAR_SEQ 320..367
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024278"
FT VARIANT 30
FT /note="A -> T (in dbSNP:rs1138293)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_031459"
FT VARIANT 128
FT /note="R -> S (in dbSNP:rs17851964)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031460"
FT VARIANT 144
FT /note="R -> T (in dbSNP:rs3738368)"
FT /id="VAR_031461"
FT CONFLICT 100
FT /note="V -> I (in Ref. 3; AAH50353)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="R -> S (in Ref. 3; AAH37879)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 45603 MW; 8000DDC8FE0C4D76 CRC64;
MTPMKRSVQT QVSEPFMESW GEESLPELPA EQSLTEYSDL EEAPSAHTLY VGHLNPQFSV
PVLACLLRDT LERLEMPVAR EHIEVVRRPR KAYALVQVTV HRDTLASLPW RLQTALEEHL
ILKELAARGK DLLLSEAQGP FSHREEKEEE EEDSGLSPGP SPGSGVPLPT WPTHTLPDRP
QAQQLQSCQG RPSGVCSDSA IVHQQIVGKD QLFQGAFLGS ETRNMEFKRG SGEYLSLAFK
HHVRRYVCAF LNSEGGSLLV GVEDSGLVQG IRCSHRDEDR ARLLVDSILQ GFKPQIFPDA
YTLTFIPVIS TSETSVPLKV IRLTVHTPKA QSQPQLYQTD QGEVFLRRDG SIQGPLSASA
IQEWCRQRWL VELGKLEEKM KALMMEKEQL QQQLQQHGPV SCTCCVL
