SLNL1_MOUSE
ID SLNL1_MOUSE Reviewed; 410 AA.
AC Q8BHW9; Q149Q6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Schlafen-like protein 1;
GN Name=Slfnl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BHW9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BHW9-2; Sequence=VSP_024279;
CC -!- SIMILARITY: Belongs to the Schlafen family. Subgroup I subfamily.
CC {ECO:0000305}.
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DR EMBL; AK077106; BAC36615.1; -; mRNA.
DR EMBL; AL611924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117545; AAI17546.1; -; mRNA.
DR EMBL; BC118052; AAI18053.1; -; mRNA.
DR CCDS; CCDS18590.1; -. [Q8BHW9-1]
DR RefSeq; NP_808238.1; NM_177570.3. [Q8BHW9-1]
DR RefSeq; XP_017175572.1; XM_017320083.1. [Q8BHW9-2]
DR AlphaFoldDB; Q8BHW9; -.
DR STRING; 10090.ENSMUSP00000050896; -.
DR iPTMnet; Q8BHW9; -.
DR PhosphoSitePlus; Q8BHW9; -.
DR PaxDb; Q8BHW9; -.
DR PRIDE; Q8BHW9; -.
DR ProteomicsDB; 261193; -. [Q8BHW9-1]
DR ProteomicsDB; 261194; -. [Q8BHW9-2]
DR Antibodypedia; 32165; 273 antibodies from 25 providers.
DR Ensembl; ENSMUST00000062990; ENSMUSP00000050896; ENSMUSG00000047518. [Q8BHW9-1]
DR GeneID; 194219; -.
DR KEGG; mmu:194219; -.
DR UCSC; uc008unh.1; mouse. [Q8BHW9-1]
DR UCSC; uc012dkj.1; mouse. [Q8BHW9-2]
DR CTD; 200172; -.
DR MGI; MGI:3045330; Slfnl1.
DR VEuPathDB; HostDB:ENSMUSG00000047518; -.
DR eggNOG; ENOG502QTT1; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR HOGENOM; CLU_034269_0_0_1; -.
DR InParanoid; Q8BHW9; -.
DR OMA; NETRNME; -.
DR OrthoDB; 1573430at2759; -.
DR PhylomeDB; Q8BHW9; -.
DR TreeFam; TF337569; -.
DR BioGRID-ORCS; 194219; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BHW9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BHW9; protein.
DR Bgee; ENSMUSG00000047518; Expressed in seminiferous tubule of testis and 7 other tissues.
DR Genevisible; Q8BHW9; MM.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.950.30; -; 1.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR029667; SLFNL1.
DR PANTHER; PTHR12155; PTHR12155; 1.
DR PANTHER; PTHR12155:SF29; PTHR12155:SF29; 1.
DR Pfam; PF04326; AlbA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Coiled coil; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..410
FT /note="Schlafen-like protein 1"
FT /id="PRO_0000283000"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..401
FT /evidence="ECO:0000255"
FT COMPBIAS 154..177
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 264..271
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 146
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024279"
SQ SEQUENCE 410 AA; 45595 MW; 9D7533499DDCDCBD CRC64;
MSLRKRSAQT QMWESPVMSQ GKQSLLELPL KESPPKDSGL KAVPSTHTLY VSHLNPQFSV
PVLACLLRDT LERLELPVAR GQIEVVRRPR NTYALVQVAA PKAVLASLPW RLQMALEEQL
ILKELTARGK ELVLSEALES LHHREQEDSG PSPSHSPGPS PGPSPGLRHP PLPQLADPSP
IWGSAGRRQI SQNRPSGVRS DSAIVHHKIL GQEQLFQGAF LGSETRNMEF KRGSGEYLSL
AFKHHVRRYV CAFLNSEGGS LLVGVEDSGL VQGIHCSHRD EDRTRLLVDS ILQGFKPQVF
PDAYTLTFIP VISTTTTSTP LKVLRLTVHT PKAQGEPQLY ETDQGEVFLR RDGSIQGPLS
VGAIQDWCRQ KWAMELGKLE EKVKVLTLEK EQLQQQLRQR QPLSCSCCVL
