SLO1_YEAST
ID SLO1_YEAST Reviewed; 85 AA.
AC Q3E784; D3DM90;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=SCOCO-like protein 1;
GN Name=SLO1; OrderedLocusNames=YER180C-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP INTERACTION WITH ARL3, AND MUTAGENESIS OF TYR-72.
RX PubMed=12620189; DOI=10.1016/s0960-9822(03)00091-5;
RA Panic B., Whyte J.R.C., Munro S.;
RT "The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with
RT vesicle-tethering factors at the Golgi apparatus.";
RL Curr. Biol. 13:405-410(2003).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-10, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=YAL6B;
RX PubMed=15665377; DOI=10.1074/mcp.m400219-mcp200;
RA Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M.,
RA Jensen O.N.;
RT "Quantitative phosphoproteomics applied to the yeast pheromone signaling
RT pathway.";
RL Mol. Cell. Proteomics 4:310-327(2005).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBUNIT: Interacts with ARL3. {ECO:0000269|PubMed:12620189}.
CC -!- SIMILARITY: Belongs to the SLO1 family. {ECO:0000305}.
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DR EMBL; U18922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006939; DAA07844.1; -; Genomic_DNA.
DR RefSeq; NP_796378.3; NM_001184517.3.
DR AlphaFoldDB; Q3E784; -.
DR SMR; Q3E784; -.
DR BioGRID; 36934; 50.
DR IntAct; Q3E784; 1.
DR STRING; 4932.YER180C-A; -.
DR iPTMnet; Q3E784; -.
DR MaxQB; Q3E784; -.
DR PaxDb; Q3E784; -.
DR PRIDE; Q3E784; -.
DR EnsemblFungi; YER180C-A_mRNA; YER180C-A; YER180C-A.
DR GeneID; 856928; -.
DR KEGG; sce:YER180C-A; -.
DR SGD; S000028437; SLO1.
DR VEuPathDB; FungiDB:YER180C-A; -.
DR eggNOG; ENOG502S763; Eukaryota.
DR HOGENOM; CLU_193956_0_0_1; -.
DR InParanoid; Q3E784; -.
DR OMA; WNKTLEQ; -.
DR BioCyc; YEAST:G3O-30393-MON; -.
DR PRO; PR:Q3E784; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; Q3E784; protein.
DR GO; GO:0006886; P:intracellular protein transport; IPI:SGD.
DR InterPro; IPR019357; SCOC.
DR Pfam; PF10224; DUF2205; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:15665377,
FT ECO:0007744|PubMed:22814378"
FT CHAIN 2..85
FT /note="SCOCO-like protein 1"
FT /id="PRO_0000076321"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:15665377,
FT ECO:0007744|PubMed:22814378"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15665377"
FT MUTAGEN 72
FT /note="Y->A: Disrupts interaction with ARL3."
FT /evidence="ECO:0000269|PubMed:12620189"
SQ SEQUENCE 85 AA; 9735 MW; 5A1CF70DB5BC42F2 CRC64;
MSAENISTGS PTGKQPSSEV NLGEREAGTK NERMMRQTKL LKDTLDLLWN KTLEQQEVCE
QLKQENDYLE DYIGNLMRSS NVLEK
