SLOU_DROME
ID SLOU_DROME Reviewed; 659 AA.
AC P22807; Q9VD96;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=Homeobox protein slou;
DE AltName: Full=Homeobox protein NK-1;
DE AltName: Full=Protein slouch;
DE AltName: Full=S59/2;
GN Name=slou; Synonyms=NK1, S59; ORFNames=CG6534;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1980118; DOI=10.1101/gad.4.12a.2098;
RA Dohrmann C., Azpiazu N., Frasch M.;
RT "A new Drosophila homeo box gene is expressed in mesodermal precursor cells
RT of distinct muscles during embryogenesis.";
RL Genes Dev. 4:2098-2111(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 497-625.
RX PubMed=2573058; DOI=10.1073/pnas.86.20.7716;
RA Kim Y., Nirenberg M.;
RT "Drosophila NK-homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989).
CC -!- FUNCTION: May play a role in specifying the identity of particular
CC somatic muscles and neurons of the CNS.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Mesodermal precursor cells of distinct muscles
CC during embryogenesis, a subset of neuronal cells of the CNS and their
CC precursors and also in cells of a small region of the midgut.
CC -!- DEVELOPMENTAL STAGE: Postgastrulation-stage.
CC -!- SIMILARITY: Belongs to the NK-1 homeobox family. {ECO:0000305}.
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DR EMBL; X55393; CAA39067.1; -; mRNA.
DR EMBL; AE014297; AAF55901.3; -; Genomic_DNA.
DR EMBL; M27289; AAA28616.1; -; Genomic_DNA.
DR PIR; A36664; A36664.
DR RefSeq; NP_476657.1; NM_057309.3.
DR AlphaFoldDB; P22807; -.
DR SMR; P22807; -.
DR BioGRID; 67513; 19.
DR DIP; DIP-17156N; -.
DR IntAct; P22807; 6.
DR STRING; 7227.FBpp0083521; -.
DR PaxDb; P22807; -.
DR EnsemblMetazoa; FBtr0084123; FBpp0083521; FBgn0002941.
DR GeneID; 42547; -.
DR KEGG; dme:Dmel_CG6534; -.
DR CTD; 42547; -.
DR FlyBase; FBgn0002941; slou.
DR VEuPathDB; VectorBase:FBgn0002941; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000172282; -.
DR HOGENOM; CLU_401307_0_0_1; -.
DR InParanoid; P22807; -.
DR OMA; MHDHLDD; -.
DR OrthoDB; 858478at2759; -.
DR PhylomeDB; P22807; -.
DR SignaLink; P22807; -.
DR BioGRID-ORCS; 42547; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42547; -.
DR PRO; PR:P22807; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002941; Expressed in embryonic/larval hypodermal muscle (Drosophila) and 7 other tissues.
DR ExpressionAtlas; P22807; baseline and differential.
DR Genevisible; P22807; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007521; P:muscle cell fate determination; IMP:FlyBase.
DR GO; GO:0007517; P:muscle organ development; TAS:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..659
FT /note="Homeobox protein slou"
FT /id="PRO_0000049070"
FT REPEAT 221..222
FT /note="1"
FT REPEAT 223..224
FT /note="2"
FT REPEAT 225..226
FT /note="3"
FT REPEAT 227..228
FT /note="4"
FT REPEAT 229..230
FT /note="5"
FT REPEAT 231..232
FT /note="6"
FT REPEAT 233..234
FT /note="7"
FT DNA_BIND 545..604
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..234
FT /note="7 X 2 AA tandem repeats of H-P"
FT REGION 316..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..234
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..516
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 69955 MW; 5D401F55C4670280 CRC64;
MVMLQSPAQK ASDSASAQNT AVGGLMSPNS NPDSPKSNTS PDVASADSVV SGTGGGSTPP
AAKIPKFIIS ANGAAVAGKQ EQELRYSLER LKQMSSESGS LLSRLSPLQE DSQDKEKPNH
NNNNSLTNHN ANSNTRRSQS PPASVGSVSF SSPAQQRKLL ELNAVRHLAR PEPLQHPHAA
LLQQHPHLLQ NPQFLAAAQQ HMHHHQHQHH QHPAHPHSHQ HPHPHPHPHP HPHPSAVFHL
RAPSSSSTAP PSPATSPLSP PTSPAMHSDQ QMSPPIAPPQ NPPHSSQPPQ QQQVAAPSDM
DLERIKLVAA VAARTTQASS TSALASASNS VSNASISISN SSSGSPSGRD LSDYGFRIQL
GGLAAAAAAA AATSRQIAAA TYARSDTSEE LNVDGNDEDS NDGSHSTPSV CPVDLTRSVN
SSAAANPSSA STSASSDRDA ATKRLAFSVE NILDPNKFTG NKLPSGPFGH PRQWSYERDE
EMQERLDDDQ SEDMSAQDLN DMDQDDMCDD GSDIDDPSSE TDSKKGGSRN GDGKSGGGGG
GGSKPRRART AFTYEQLVSL ENKFKTTRYL SVCERLNLAL SLSLTETQVK IWFQNRRTKW
KKQNPGMDVN SPTIPPPGGG SFGPGAYASG LLYSHAVPYP PYGPYFHPLG AHHLSHSHS
