ID   169_VACCW               Reviewed;          78 AA.
AC   Q80HU0;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Protein 169;
GN   OrderedLocusNames=VACWR169;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=26334635; DOI=10.1371/journal.ppat.1005151;
RA   Strnadova P., Ren H., Valentine R., Mazzon M., Sweeney T.R., Brierley I.,
RA   Smith G.L.;
RT   "Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus
RT   Strategy to Suppress Innate and Adaptive Immunity and Alter Virus
RT   Virulence.";
RL   PLoS Pathog. 11:E1005151-E1005151(2015).
CC   -!- FUNCTION: Plays a role in the inhibition of host protein synthesis.
CC       Specifically, inhibits the initiation of cap-dependent and cap-
CC       independent translation. In turn, affects the outcome of infection by
CC       decreasing recruitment of inflammatory leukocytes and reducing the
CC       memory CD8+ T-cell response. {ECO:0000269|PubMed:26334635}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:26334635}.
CC       Note=Localizes in cytoplasmic structures that differ from virus
CC       factories. {ECO:0000269|PubMed:26334635}.
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DR   EMBL; AY243312; AAO89448.1; -; Genomic_DNA.
DR   PIR; JQ1781; JQ1781.
DR   RefSeq; YP_233051.1; NC_006998.1.
DR   DNASU; 3707699; -.
DR   GeneID; 3707699; -.
DR   KEGG; vg:3707699; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0039504; P:suppression by virus of host adaptive immune response; IDA:UniProtKB.
DR   GO; GO:0039604; P:suppression by virus of host translation; IDA:UniProtKB.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host translation shutoff by virus; Host cytoplasm;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Inhibition of eukaryotic host translation factors by virus;
KW   Inhibition of host adaptive immune response by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..78
FT                   /note="Protein 169"
FT                   /id="PRO_0000412176"
SQ   SEQUENCE   78 AA;  8778 MW;  D1564471E94E2A6D CRC64;
     MLLEMDKIKI TVDSKIGNVV TISYNLEKIT IDVTPKKKKE KDVLLAQSVA VEEAKDVKVE
     EKNIIDIEDD DDMDVESA