SLP1_PINMA
ID SLP1_PINMA Reviewed; 336 AA.
AC P86949;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Shematrin-like protein 1;
DE Flags: Precursor;
OS Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX NCBI_TaxID=104660;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RC TISSUE=Mantle {ECO:0000269|PubMed:19915030};
RX PubMed=19915030; DOI=10.1093/molbev/msp278;
RA Jackson D.J., McDougall C., Woodcroft B., Moase P., Rose R.A., Kube M.,
RA Reinhardt R., Rokhsar D.S., Montagnani C., Joubert C., Piquemal D.,
RA Degnan B.M.;
RT "Parallel evolution of nacre building gene sets in molluscs.";
RL Mol. Biol. Evol. 27:591-608(2010).
RN [2]
RP PROTEIN SEQUENCE OF 88-120, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Shell;
RX PubMed=23213212; DOI=10.1073/pnas.1210552109;
RA Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C.,
RA Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.;
RT "Different secretory repertoires control the biomineralization processes of
RT prism and nacre deposition of the pearl oyster shell.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23213212}.
CC -!- TISSUE SPECIFICITY: Prismatic layer of shell (at protein level).
CC Expressed primarily in the mantle with highest level in the mantle edge
CC and lower level in the mantle pallium. {ECO:0000269|PubMed:23213212}.
CC -!- SEQUENCE CAUTION:
CC Sequence=GT280050; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT284329; Type=Miscellaneous discrepancy; Note=Premature stop codon at position 197.; Evidence={ECO:0000305};
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DR EMBL; GT277828; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279244; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279430; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279725; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279835; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279874; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280050; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280271; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280629; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280763; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280887; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281002; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281306; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281323; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281328; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281929; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281981; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282227; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282493; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282546; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282619; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283446; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283543; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284078; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284191; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284329; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EZ420070; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P86949; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..336
FT /note="Shematrin-like protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413084"
FT CONFLICT 99
FT /note="L -> H (in Ref. 1; GT279430)"
FT /evidence="ECO:0000305"
FT CONFLICT 124
FT /note="S -> N (in Ref. 1; GT283543)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="S -> T (in Ref. 1; GT277828)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="P -> S (in Ref. 1; GT283446)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="G -> R (in Ref. 1; GT277828)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="G -> R (in Ref. 1; GT283446)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="G -> R (in Ref. 1; GT283446/GT282227)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="G -> R (in Ref. 1; GT282227)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="G -> R (in Ref. 1; GT283446/GT279835)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="G -> R (in Ref. 1; GT280050)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="G -> S (in Ref. 1; GT280050/GT280887/GT282493)"
FT /evidence="ECO:0000305"
FT CONFLICT 194..227
FT /note="ISSPTSGVTIPYGGALGLYGGYGGYGLGSTYGGY -> M (in Ref. 1;
FT GT281002)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="P -> S (in Ref. 1; GT279725)"
FT /evidence="ECO:0000305"
FT CONFLICT 210..211
FT /note="GL -> RM (in Ref. 1; GT279725)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="L -> M (in Ref. 1; GT284191)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 32794 MW; 9ADB83E4EFDEDFD7 CRC64;
MLRFIAIVAL IATVNAKGGT YGIGVLPSVT YVSGGGGGYP GIYGTYGGGF PGIYGGFGPG
GVYGSINSYG GVSTGAYGLY GTSPAVRGAA QGAAAASALG IASGVPSRVS GSSIGIGGGR
ALVSGSATPI GYYGVPYGGY GYGVPSYGYG YGYPSYGISY GYPGYGYGGY GGYGYPDVAY
FGGSTYGNLA TGAISSPTSG VTIPYGGALG LYGGYGGYGL GSTYGGYGYG VPSYGYGYGY
PSYGISYGYP GYGYGGYGGY GYPDVAHFGG STYGNLATGA ISSPTSGVTI PYGGALGLYG
GYGSYGYGPG IYGGGIYGSG GGIYSGGATI IRRKKY
