SLPI_SCHPO
ID SLPI_SCHPO Reviewed; 659 AA.
AC O59729;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Uncharacterized protein slp1 {ECO:0000250|UniProtKB:Q12232};
DE AltName: Full=SUN-like protein 1 {ECO:0000250|UniProtKB:Q12232};
DE Flags: Precursor;
GN ORFNames=SPBC3E7.09 {ECO:0000312|PomBase:SPBC3E7.09};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May be involved in membrane protein folding.
CC {ECO:0000250|UniProtKB:Q12232}.
CC -!- SUBUNIT: Interacts with EMP65. {ECO:0000250|UniProtKB:Q12232}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q12232}; Single-pass type I membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA19012.1; -; Genomic_DNA.
DR PIR; T40383; T40383.
DR RefSeq; NP_596096.1; NM_001022012.2.
DR AlphaFoldDB; O59729; -.
DR SMR; O59729; -.
DR BioGRID; 276806; 1.
DR STRING; 4896.SPBC3E7.09.1; -.
DR iPTMnet; O59729; -.
DR MaxQB; O59729; -.
DR PaxDb; O59729; -.
DR PRIDE; O59729; -.
DR EnsemblFungi; SPBC3E7.09.1; SPBC3E7.09.1:pep; SPBC3E7.09.
DR GeneID; 2540275; -.
DR KEGG; spo:SPBC3E7.09; -.
DR PomBase; SPBC3E7.09; -.
DR VEuPathDB; FungiDB:SPBC3E7.09; -.
DR eggNOG; KOG1396; Eukaryota.
DR HOGENOM; CLU_416284_0_0_1; -.
DR InParanoid; O59729; -.
DR OMA; YESSWME; -.
DR PhylomeDB; O59729; -.
DR PRO; PR:O59729; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0034975; P:protein folding in endoplasmic reticulum; ISO:PomBase.
DR InterPro; IPR045120; Suco/Slp1-like.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12953; PTHR12953; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR PROSITE; PS51469; SUN; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..659
FT /note="Uncharacterized protein slp1"
FT /id="PRO_0000363387"
FT TOPO_DOM 26..556
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q12232"
FT TRANSMEM 557..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 575..659
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q12232"
FT DOMAIN 173..335
FT /note="SUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00802"
FT REGION 417..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 415
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 495
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 504
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 659 AA; 74072 MW; B0AC716FA05263CC CRC64;
MVKRRLSAFG NAFLIYFIIF RLCCCSPQTS HWCKYPALCL KSPDTHNENL VCDAYLSVIA
TKSEEKEASN PTTWDFTPTN KYQEPSFHTK TSLNGSDTIS SNFLSKYEYS NGTSTSEFID
SISPPLVNET STISSSKKLE QNYSVTEVID TNIITSSSVT LPISEDGSST SAAATIDSNI
DEKTVAFSEE KRFNFASTDC AAAVIKTNPE AVGSSSILTE NKDKYMLNKC SAENKFVVIE
LCEDIYVDTV QIANFEFFSS IFRDFKVSVS GKYPKYESSW MELGTFTALN LRTLQSFHIE
NPLIWAKYLK IEFLTHYGSE FYCPVSLLRV YGKTMIEEFE EANEDFLEQK VNDGSAIKAD
EIRKPQESPI FVDEEDTDVQ SKPVRKNPSV ELNSTDTLLS STVISKSLST VVIGNETGKS
ESYPATSTRS FNDISPSSSS SYSTAQISTF PSNQESIYKN INKRLSTLEE RKKAFDEIVE
KILTNYGKHN AKNMNFTQLL HELNSTLQLE ISKLSKSVVK PSLFALQAKL ELLSAENEYF
QSQITSLYQE SSFQKRLLML QLTVLIVLTV YMAVSRLPEN LPTTRSSSNN PIEASRPPFS
RDEQDISKAN DFRVSASSAV YTVGPELLQR KKRDPNTSIR SIHEREQDKI IHSRSHSVC
