SLRA_DICDI
ID SLRA_DICDI Reviewed; 1378 AA.
AC Q54T74;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=S-cell enriched with leucine-rich repeat-containing protein slrA;
GN Name=slrA; ORFNames=DDB_G0282069;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=17673666; DOI=10.1126/science.1143991;
RA Chen G., Zhuchenko O., Kuspa A.;
RT "Immune-like phagocyte activity in the social amoeba.";
RL Science 317:678-681(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Only expressed in sentinel 'S-cells'.
CC {ECO:0000269|PubMed:17673666}.
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DR EMBL; AAFI02000044; EAL66456.1; -; Genomic_DNA.
DR RefSeq; XP_640377.1; XM_635285.1.
DR AlphaFoldDB; Q54T74; -.
DR SMR; Q54T74; -.
DR STRING; 44689.DDB0232377; -.
DR PaxDb; Q54T74; -.
DR EnsemblProtists; EAL66456; EAL66456; DDB_G0282069.
DR GeneID; 8623330; -.
DR KEGG; ddi:DDB_G0282069; -.
DR dictyBase; DDB_G0282069; slrA.
DR eggNOG; ENOG502RSTU; Eukaryota.
DR HOGENOM; CLU_255817_0_0_1; -.
DR InParanoid; Q54T74; -.
DR OMA; CECYPNL; -.
DR PRO; PR:Q54T74; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 6.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1378
FT /note="S-cell enriched with leucine-rich repeat-containing
FT protein slrA"
FT /id="PRO_0000391769"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1160..1180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 143..165
FT /note="LRR 1"
FT REPEAT 167..188
FT /note="LRR 2"
FT REPEAT 191..212
FT /note="LRR 3"
FT REPEAT 213..235
FT /note="LRR 4"
FT REPEAT 236..257
FT /note="LRR 5"
FT REPEAT 260..281
FT /note="LRR 6"
FT REPEAT 282..304
FT /note="LRR 7"
FT REPEAT 307..329
FT /note="LRR 8"
FT REPEAT 331..353
FT /note="LRR 9"
FT REGION 891..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 886..946
FT /evidence="ECO:0000255"
FT COMPBIAS 891..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1324
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 287
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 451
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 513
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 596
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 634
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 710
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 740
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 741
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 771
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 788
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 801
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 826
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 843
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 861
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 875
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 907
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 953
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 970
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1090
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1378 AA; 156164 MW; B686F2C4DCF7EF33 CRC64;
MVKNQIFSLK SLWSSSIFKI LYCYLFTSLL LILSTWVSVN DGLSVREHII LLRLYFDTNG
TTWYHNQGWK EYADCILAAD GSVRKALESI DPLTGQIPQY LWADHFSQLD NNKTLYKIIH
NQIQGHKVVI CNAFGITCED RINLTGIDLS NNNLKGNITP YLPYLLHLRN LNLSNNHLSG
CFPDGLLKAQ SLVALDLSYN NISCTLSLAD SKAISYIDIS HNHLTGYFKN VWKTPNLLFL
DLSFNKLYGT ILKEFFRQKS LDYVNLSSNQ LIGFLPILSK SRISYLNISN NRLIGNITLL
TCWKAGSLRI FDAENNMFEG ALPESIFDHS PLQYVNLKGN IVKDPLPSIL DCAKSEVKII
VPDGLKQNKC DPKVSSNWVL ILNPLGEEFN IVGSDFGINS KSINIQFQNG LHCVDNVTTI
IKSNTIISCK NPQGRNSTYL KLTIPTGEPG NFTVIKQQLY YYRPIIKSCS KVYKNIGGEI
TILGSHLESF NKTSNGKKMI TVSIGNIKNS FTNVTSSINS DGFSGEVISC RNADIITPDM
ITCSIPSNTN LQQPAEIQII IDGITAYVPI DSTRPHFLYK GVYNKDITIS KPTEYNQTIT
ISVPNETIID MDQVVRVLID DNDDSICKNI QHINKTSIQC LPYSETCGSN VKVTLVTKYG
EPQFTTSLNY PPPIITRVTQ GIDSTSNSII TINGKFLKTG GKRNLSIKIN DTICCPLYNE
YYYKQDELDD DNNNNNNNNN NSTTDINNNN NIIKNNNLIK EEQILCYYQI NQSLPIHLNL
PVTLTLSNQT VVKNNIYSQT NSTCPNNCVK HRTNGCRSGI CECYPNLTGP SCDENIPEST
ISNFSNYLPD FILSFPKFIT NNTFNIKFLS ISEVNESGNI VDRFCSLNNN NNNNNNNNNK
NNNNNNNDSN NEKEVVEDEE EDLDYSSQND NNNINNNNNE NNNENKLNWK LINQTKTTNA
LYTLKIKKKN VTLDILISSD NNQHREVYFA GEVIQVPKSS IELIVNLKGK WLFKDPKNQL
KFNFLVKPVN DHDYSLCLPS PFVLISDEPF RWITMDVDSS TIFAKPSNRF LLNNYLVRVI
EPNYKLSDSN LTLNLYYQFN QTTLKQQDNH GDDNSDNSIK YTEDSLKFRI DFSTFNSRRE
INPKPRGCFK DNTHKFPYDY YIVFFGCASG LILVLVICIV QCSRIESRQR KQIIKSFKAT
QKMPVEIKTP LLPPSFHFNF LDYNNMDLNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NFNDGSDTFN NNNKKNLNYE DNCDTVGFDG KENDIKNINN KKDEKEDDGD DDDDEDDDEY
EDDTQPCSSG NSSRSKGSDG GSSSNSLSSD KQSFNNGNEN NSIIPENKKK HLTIINKK
