ID   SLRR_BACSU              Reviewed;         152 AA.
AC   P71049; O07961; O08168; Q795I0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=HTH-type transcriptional regulator SlrR;
GN   Name=slrR; Synonyms=slr, yveJ; OrderedLocusNames=BSU34380;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969506; DOI=10.1099/13500872-142-11-3089;
RA   Fabret C., Quentin Y., Chapal N., Guiseppi A., Haiech J., Denizot F.;
RT   "Integrated mapping and sequencing of a 115 kb DNA fragment from Bacillus
RT   subtilis: sequence analysis of a 21 kb segment containing the sigL locus.";
RL   Microbiology 142:3089-3096(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Dartois V.A., Ferrari E., Hoch J.A.;
RT   "Identification of a SinR-homolog involved in initiation of competence
RT   development and sporulation in Bacillus subtilis.";
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Denizot F.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [5]
RP   FUNCTION.
RX   PubMed=18430133; DOI=10.1111/j.1365-2958.2008.06201.x;
RA   Chu F., Kearns D.B., McLoon A., Chai Y., Kolter R., Losick R.;
RT   "A novel regulatory protein governing biofilm formation in Bacillus
RT   subtilis.";
RL   Mol. Microbiol. 68:1117-1127(2008).
RN   [6]
RP   FUNCTION.
RX   PubMed=18647168; DOI=10.1111/j.1365-2958.2008.06369.x;
RA   Kobayashi K.;
RT   "SlrR/SlrA controls the initiation of biofilm formation in Bacillus
RT   subtilis.";
RL   Mol. Microbiol. 69:1399-1410(2008).
CC   -!- FUNCTION: Represses sigma(D)-dependent flagellar genes and activate the
CC       eps and yqxM operons. Repressor activity is regulated by SlrA. Controls
CC       the initiation of biofilm formation. {ECO:0000269|PubMed:18430133,
CC       ECO:0000269|PubMed:18647168}.
CC   -!- SUBUNIT: Component of the SlrR/SlrA complex.
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DR   EMBL; Z71928; CAA96488.1; -; Genomic_DNA.
DR   EMBL; U46134; AAB39888.1; -; Genomic_DNA.
DR   EMBL; Z94043; CAB08022.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15443.1; -; Genomic_DNA.
DR   PIR; E69708; E69708.
DR   RefSeq; NP_391318.1; NC_000964.3.
DR   RefSeq; WP_003242589.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; P71049; -.
DR   SMR; P71049; -.
DR   STRING; 224308.BSU34380; -.
DR   PaxDb; P71049; -.
DR   PRIDE; P71049; -.
DR   EnsemblBacteria; CAB15443; CAB15443; BSU_34380.
DR   GeneID; 938581; -.
DR   KEGG; bsu:BSU34380; -.
DR   PATRIC; fig|224308.179.peg.3724; -.
DR   eggNOG; COG1396; Bacteria.
DR   InParanoid; P71049; -.
DR   OMA; FTFTNRL; -.
DR   PhylomeDB; P71049; -.
DR   BioCyc; BSUB:BSU34380-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR010981; SinR/SinI_dimer_dom.
DR   InterPro; IPR036281; SinR/SinI_dimer_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF08671; SinI; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47406; SSF47406; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
DR   PROSITE; PS51500; SIN; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..152
FT                   /note="HTH-type transcriptional regulator SlrR"
FT                   /id="PRO_0000360160"
FT   DOMAIN          6..61
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DOMAIN          113..151
FT                   /note="Sin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00833"
FT   DNA_BIND        17..36
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   152 AA;  17570 MW;  A8B7D4C458629C59 CRC64;
     MIGRIIRLYR KRKGYSINQL AVESGVSKSY LSKIERGVHT NPSVQFLKKV SATLEVELTE
     LFDAETMMYE KISGGEEEWR VHLVQAVQAG MEKEELFTFT NRLKKEQPET ASYRNRKLTE
     SNIEEWKALM AEAREIGLSV HEVKSFLKTK GR